Oral vaccination of fish: Lessons from humans and veterinary species

Embregts, Carmen W.E.; Forlenza, Maria

doi:10.1016/j.dci.2016.03.024

Cited by 147 publications

(108 citation statements)

References 160 publications

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“…For instance, current research efforts aim to further investigate the role of mucosal immunity in teleost fish and characterize the immunopotentiating interactions with the gut microbiome [92]. Further, this systemic understanding has many applications for oral vaccination design and the development of protective responses within the fish [93] [94]. The future development and improved efficiency of immune-enhancing feedstuffs and disease management strategies should promote more superior yields and increase the sustainability of intensive aquaculture.…”

Section: Discussionmentioning

confidence: 99%

A Review of Immune System Components, Cytokines, and Immunostimulants in Cultured Finfish Species

Bruce¹,

Brown²

2017

OJAS

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Aquaculture is a rapidly growing global agriculture sector and the importance of fish health has become of upmost importance as production levels and stocking densities increase. Over the past few decades, there have been a large number of immunological investigations on commonly cultured finfish species. Further, new technologies and strategies that embody use of fish immunostimulants, probiotics, and vaccinology rely heavily upon a comprehensive understanding of teleost immune system mechanics. The teleost immune system works in concert to properly recognize, control, and clear aquatic pathogens. Recent findings have exemplified the cooperative efforts of the nonspecific and adaptive branches, and have put forth an emphasis on the importance of the mucosal immune response in all aspects of a mounted immune response. This review provides a generalized overview of the innate and adaptive arms of the fish immune system, and provides highlights of recently published work in the areas of signaling networks and mucosal immune interactions.

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Section: Discussionmentioning

confidence: 99%

A Review of Immune System Components, Cytokines, and Immunostimulants in Cultured Finfish Species

Bruce¹,

Brown²

2017

OJAS

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“…Degradation of antigens in the highly tolerogenic gut environment is a main reason for limited efficacy of oral vaccines in fish. 14,15 In conclusion, the results of the genome sequence analysis reported here for V. mimicus provides genetic basis for the development of subunit and live attenuated vaccine. Moreover, immersion challenge test indicated that strain SCCF01 has the ability of colonization and adhesion to the mucosal surfaces, which is promising for attenuated vaccine development.…”

Section: To the Editormentioning

confidence: 99%

Complete genome sequence ofVibrio mimicusstrain SCCF01 with potential application in fish vaccine development

Geng

Wang

et al. 2016

Virulence

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Vibrio mimicus strain SCCF01 was isolated from the yellow catfish (Pelteobagrus fulvidraco) during a mass mortality event at an aquaculture facility. We sequenced the genome of strain SCCF01, then predicted possible effective targets for subunit vaccine and identified possible virulence genes for live attenuated vaccine. The genome of SCCF01 consists of 2 circular chromosomes of 3,213,040 and 1,272,975 bp with G+C content of 46.61% and 45.88%, respectively. Subcellular localization, number of transmembrane helices and adhesion probability were predicted by Vaxign programs. Several candidate virulence genes were identified using the Virulence Factors Database. The genomic information presented herein will be useful for future studies investigating the pathogenesis of V. mimicus and with vaccine development.Vibrio mimicus is an enteric pathogen that is widely distributed in aquatic environments that can infect and cause disease in fish.1,2 Additionally, the pathogen is zoonotic and can cause bacterial gastroenteritis and food poisoning in humans if infected fish are consumed.2 Hence, understanding the pathogenesis of V. mimicus and developing a vaccine to treat infected fish hosts is an important research direction. In this study, we revived V. mimicus strain SCCF01 from the farmed yellow catfish (Pelteobagrus fulvidraco) in Sichuan Province, China, during a mass mortality event.3 Our objectives were to: (1) characterize the SCCF01 genome, (2) predict possible effective targets for subunit vaccine, (3) identify possible virulence genes that could lead to development of attenuated V. mimicus for vaccine development, and (4) identify the ability of colonization and adhesion of V. mimicus infection in yellow catfish.The whole-genome sequence of SCCF01 strain was determined with single molecule real-time (SMRT) sequencing platform PacBio RS II. Single SMRT cells produced 35,089 reads for 306,431,068 bases (N50 size 12,135 bp and mean read length 8,732 bp). Subsequently, the sequence reads were assembled using the PacBio SMRT Analysis (ver. 2.3.0) with default options.

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“…Effective routes for vaccine administration in fish include oral, immersion, dip or bath, anal intubation and injection (Li, Ma, & Woo, ). However, bath or immersion vaccination is the most practical method for small‐sized fishes, including fingerlings (Embregts & Forlenza, ). Furthermore, formalin‐killed and live attenuated vaccines are mucosal vaccines, which are suitable for bath or immersion vaccination in aquaculture (Soto, Griffin, & Tobar, ).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of bath vaccination with a live attenuated Vibrio harveyi against vibriosis in Asian seabass fingerling, Lates calcarifer

et al. 2019

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Vibrio harveyi causes vibriosis in various marine aquaculture fish species, especially when they are young. The infection subsequently leads to significant economic losses for aquaculture farms. Vaccination is recommended to control this disease. This study describes the efficacy of a live attenuated V. harveyi strain MVh_vhs (LAVh) as a vaccine candidate in controlling infection by wild‐type V. harveyi (WTVh) in Lates calcarifer. A total of 240 fingerlings were divided into four groups. Group 1 was not vaccinated and was not challenged, Group 2 was vaccinated with a formalin‐killed V. harveyi (FKVh), Group 3 was vaccinated with the LAVh before challenge and Group 4 was not vaccinated and was challenged. Bath vaccination was employed for one hour before the LAVh distribution was determined in the fish mucus, gill, liver, gut, kidney and spleen. The gills, livers, kidneys and skins were also sampled for gene expression analysis. To challenge the fish, skin abrasion was conducted before the fish were challenged by immersion with WTVh. The results revealed an extensive distribution of the LAVh in the liver and kidneys of the fish in Group 3 for the first 12 hr, resulting in mild lesions compared with Group 1. Similarly, there were significantly (p < .05) higher expressions of the Chemokine ligand 4 and major histocompatibility complex I genes in the skin and liver of the fish in Group 3 in comparison with other groups. Vaccination with LAVh resulted in a significantly high rate of survival (68%) of the fingerlings after being challenged with WTVh.

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Oral vaccination of fish: Lessons from humans and veterinary species

Cited by 147 publications

References 160 publications

A Review of Immune System Components, Cytokines, and Immunostimulants in Cultured Finfish Species

A Review of Immune System Components, Cytokines, and Immunostimulants in Cultured Finfish Species

Complete genome sequence ofVibrio mimicusstrain SCCF01 with potential application in fish vaccine development

Efficacy of bath vaccination with a live attenuated Vibrio harveyi against vibriosis in Asian seabass fingerling, Lates calcarifer

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