Oral vaccination with immune stimulating complexes

Mowat, Allan McI; Smith, Rosemary E.; Donachie, Anne M.; Furrie, Elizabeth; Grdic, Dubravka; Lycke, Nils

doi:10.1016/s0165-2478(98)00136-9

Cited by 49 publications

(28 citation statements)

References 23 publications

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“…ISCOMs have been reported to induce antibody responses or protective immunity in guinea-pig, turkey, cat, rabbit, dog, seal, sheep, pig, cow, horse or monkeys (Mowat et al, 1999) and induced specific CTL responses (Coulter et al, 1998). Cholera toxin A1 (CTA1-DD) and an unrelated antigen can be incorporated together into the ISCOM, resulting in greatly augmented immunogenicity of the antigen.…”

Section: Immunostimulating Complex (Iscom)mentioning

confidence: 99%

Adjuvant effects of saponins on animal immune responses

Rajput

Xiao

et al. 2007

J. Zhejiang Univ. - Sci. B

223

149

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Abstract:Vaccines require optimal adjuvants including immunopotentiator and delivery systems to offer long term protection from infectious diseases in animals and man. Initially it was believed that adjuvants are responsible for promoting strong and sustainable antibody responses. Now it has been shown that adjuvants influence the isotype and avidity of antibody and also affect the properties of cell-mediated immunity. Mostly oil emulsions, lipopolysaccharides, polymers, saponins, liposomes, cytokines, ISCOMs (immunostimulating complexes), Freund's complete adjuvant, Freund's incomplete adjuvant, alums, bacterial toxins etc., are common adjuvants under investigation. Saponin based adjuvants have the ability to stimulate the cell mediated immune system as well as to enhance antibody production and have the advantage that only a low dose is needed for adjuvant activity. In the present study the importance of adjuvants, their role and the effect of saponin in immune system is reviewed.

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Section: Immunostimulating Complex (Iscom)mentioning

confidence: 99%

Adjuvant effects of saponins on animal immune responses

Rajput

Xiao

et al. 2007

J. Zhejiang Univ. - Sci. B

223

149

View full text Add to dashboard Cite

show abstract

“…Easily preparable vaccines such as antigens associated with cellular debris, or currently existing vaccines such as -propiolactoneinactivated viruses should be analysed. In addition, adjuvants that can be delivered orally such as microparticles (Partidos et al, 1999) or ISCOMs (Mowat et al, 1991(Mowat et al, , 1999 should be examined. Microparticles have already been described as oral vaccines in rainbow trout (Lavelle et al, 1997), and ISCOMs have been shown to induce a humoral immune response after oral application in Oreochromis mossambicus (Jenkins et al, 1994).…”

Section: Which Approaches Toward Ctl-stimulating Vaccines Should Bmentioning

confidence: 99%

Exogenous antigens and the stimulation of MHC class I restricted cell-mediated cytotoxicity: possible strategies for fish vaccines

Dijkstra

Fischer

Sawamoto

et al. 2001

Fish & Shellfish Immunology

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“…A number of studies have provided evidence for the potential of ISCOMs as particulate adjuvants for both oral (Mowat et al, 1999) and nasal (Hu et al, 2001) vaccines, respectively. Indeed, Aguila et al (2006) demonstrated that diphtheria toxin could be incorporated into ISCOMs, and that this formulation was both effective and well tolerated when administered parenterally and mucosally.…”

Section: Immune Responses Triggered By Iscomsmentioning

confidence: 99%