Oral versus intraperitoneal administration of irinotecan in the treatment of human neuroblastoma in nude mice

Enhanced tumor killing by Apo2L/TRAIL and CPT-11 co-treatment is associated with p21 cleavage and differential regulation of Apo2L/TRAIL ligand and its receptors

“…Second, the enhanced activity observed in combination treatment did not require extraordinary concentrations of CPT-11. This eect was observed in these studies with concentrations of CPT-11 and SN-38 consistent with plasma concentrations reported for preclinical and clinical studies (Rothenberg et al, 1993;Sparreboom et al, 1998;Choi et al, 1998).…”

The Use of Olaparib (AZD2281) Potentiates SN-38 Cytotoxicity in Colon Cancer Cells by Indirect Inhibition of Rad51-Mediated Repair of DNA Double-Strand Breaks

“…Dose of irinotecan employed in this study seems to be lower than LD 50 reported in the nude mouse (177 mg/kg, i.p. ), although LD 50 of irinontecan in SHO mouse was not reported elsewhere (46). Tentori and colleagues reported that PARP inhibitor prevents irinotecan-induced intestinal damage in in vivo study using rat models (29).…”

Successful clinical response to irinotecan in desmoplastic round blue cell tumor

“…Irinotecan is a prodrug that must be metabolized to the active SN-38, which is up to 100 times more cytotoxic than the parent agent [12]. Irinotecan has shown significant preclinical activity against a variety of pediatric tumor xenografts, including neuroblastoma, several types of brain tumors, rhabdomyosarcoma, and primitive neuroectodermal tumor [13][14][15][16][17][18][19]. The related topoisom- erase I inhibitor topotecan also has significant antitumor activity in children and is currently being used in several Phase II trials in solid tumors.…”