Orally Administered Phytonadione in Bishydroxycoumarin-Induced Hypoprothrombinemia

Oral and Intravenous Estrogens in the Treatment and Prevention of Bleeding Associated With Long‐term Anticoagulant Therapy

“…, certain of the indanedione agents). The recommended dose of vitamin K 1 is 2.5 to 10 mg. orally for marked reduction of prothrombin activity without hemorrhagic phenomena (5 mg. if the prothrombin time is 45–60 seconds, and 10 mg. if it exceeds 60 seconds); 25 mg. orally or intravenously for minor bleeding; and 50 mg. or more intravenously in the case of severe hemorrhage (20–22). By employing small doses, early resumption of anticoagulant therapy is permitted without inducing refractoriness.…”