2020
DOI: 10.1080/17425247.2021.1856073
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Orally administered self-emulsifying drug delivery system in disease management: advancement and patents

Abstract: Please download and read the instructions before proceeding to the peer review Orally administered self-emulsifying drug delivery system in disease management: Advancement and Patents

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Cited by 45 publications
(24 citation statements)
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“…However, most existing drugs and chemical entities have poor water solubility [28] . For the formulation of these drugs, several formulation strategies have been developed [ 32 , 33 ]. Among these, the solution is the simplest and its cost is the lowest [ 34 , 35 ].…”
Section: Resultsmentioning
confidence: 99%
“…However, most existing drugs and chemical entities have poor water solubility [28] . For the formulation of these drugs, several formulation strategies have been developed [ 32 , 33 ]. Among these, the solution is the simplest and its cost is the lowest [ 34 , 35 ].…”
Section: Resultsmentioning
confidence: 99%
“…This process reduces the droplet size of the emulsion and leads to an emulsion of nano size. The mechanism of sonication is responsible for the reduction of the droplet size (Mishra et al., 2021 ).…”
Section: Methods Of Preparation Of Seddsmentioning
confidence: 99%
“…The poor water solubility and active chemical properties limit its application in food and pharmaceutical industries. Oral administration is the most common, ideal, and convenient route for many drugs or bioactive molecule administration [ 14 ]. To improve the bioavailability of genipin through oral administration, nanocrystals [ 15 ], cyclodextrin embedding [ 16 ], and hydrogel [ 17 ] were reported to improve its water solubility and intestinal absorption.…”
Section: Introductionmentioning
confidence: 99%
“…Lipid-based emulsion systems, including microemulsion, nanoemulsion, niosomes, SMEDDS (self microemulsifying drug delivery systems), and SNEDDS (self-nanoemulsifying drug delivery systems), have been proven to promote solubility and bioavailability, highlighting the potential value of this type of delivery approach for water-insoluble bioactive molecules [ 18 , 19 , 20 ]. Furthermore, encapsulating drugs in emulsion can also protect it from degeneration, control the release, and minimize the side effects [ 14 , 21 ].…”
Section: Introductionmentioning
confidence: 99%