Orally administrated chitosan microspheres bind Helicobacter pylori and decrease gastric infection in mice

Henriques, Patrícia C.; Costa, Lia M.; Seabra, Catarina Leal; Antunes, Bernardo; Silva-Carvalho, Ricardo; Junqueira-Neto, Susana; Maia, André F.; Oliveira, Pedro F.; Magalhães, Ana; Reis, Celso A.; Gärtner, Fátima; Touati, Eliette; Gomes, Joana; Costa, Paulo; Martins, M. Cristina L.; Gonçalves, Inês C.

doi:10.1016/j.actbio.2020.06.035

Cited by 24 publications

(25 citation statements)

References 92 publications

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“…Many factors were considered as the causative of a different outcome, such as animal model strain, H . pylori strain, and inoculation period 14,15,22,40,41,43,62‐75 . The relevance of inoculation duration in the pathological result of H .…”

Section: Resultsmentioning

confidence: 99%

“…Many factors were considered as the causative of a different outcome, such as animal model strain, H. pylori strain, and inoculation period. 14,15,22,40,41,43,[62][63][64][65][66][67][68][69][70][71][72][73][74][75] The relevance of inoculation duration in the pathological result of H. pylori infection was demonstrated in research by Bazin et al 15 Using the C57BL/6 mouse strain and the SS1 H. pylori strain, the early infection caused inflammation and caused hyperplasia after 3 months, but the inoculation caused intestinal metaplasia after 18 months. During the inoculation period, the consequence becomes increasingly severe.…”

Section: Figure Adapted Frommentioning

confidence: 99%

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A comprehensive evaluation of an animal model for Helicobacter pylori‐associated stomach cancer: Fact and controversy

et al. 2023

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Even though Helicobacter pylori infection was the most causative factor of gastric cancer, numerous in vivo studies failed to induce gastric cancer using H. pylori infection only. The utilization of established animal studies in cancer research is crucial as they aim to investigate the coincidental association between suspected oncogenes and pathogenesis as well as generate models for the development and testing of potential treatments. The methods to establish gastric cancer using infected animal models remain limited, diverse in methods, and showed different results. This study investigates the differences in animal models, which highlight different pathological results in gaster by literature research. Electronic databases searched were performed in PubMed, Science Direct, and Cochrane, without a period filter. A total of 135 articles were used in this study after a full‐text assessment was conducted. The most frequent animal models used for gastric cancer were Mice, while Mongolian gerbils and Transgenic mice were the most susceptible model for gastric cancer associated with H. pylori infection. Additionally, transgenic mice showed that the susceptibility to gastric cancer progression was due to genetic and epigenetic factors. These studies showed that in Mongolian gerbil models, H. pylori could function as a single agent to trigger stomach cancer. However, most gastric cancer susceptibilities were not solely relying on H. pylori infection, and numerous factors are involved in cancer progression. Further study using Mongolian gerbils and Transgenic mice is crucial to conduct and establish the best models for gastric cancer associated H. pylori.

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Section: Resultsmentioning

confidence: 99%

Section: Figure Adapted Frommentioning

confidence: 99%

A comprehensive evaluation of an animal model for Helicobacter pylori‐associated stomach cancer: Fact and controversy

et al. 2023

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“…32 Helicobacter is a well-known human pathogen that causes gastritis and gastric cancer. 33 Fortunately, MFGs (especially human MFGs) effectively inhibited the crosslinking of module III by these pathogens, thereby reducing the risk of disease.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Effects of Human, Caprine, and Bovine Milk Fat Globules on Microbiota Adhesion and Gut Microecology

Yao

Zhou

Hadiatullah

et al. 2021

J. Agric. Food Chem.

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Milk fat is an essential nutrient for infant development. The effects and mechanisms of human, caprine, and bovine milk fat globules (MFGs) on the gut microbiota were investigated in this study. Human MFGs enhance the efficacy of probiotics by inhibiting pathogen function. Akkermansia and Bif idobacterium were identified as the dominant microbiota by human MFGs. Mucin and complement inhibitory proteins in human MFGs were found to inhibit different pathogens. Caprine MFGs directly promoted the colonization of probiotics and the emergence of the biomarker Allobaculum. Mucin 1 in caprine MFGs was primarily responsible for inducing probiotic adhesion. Bovine MFGs increased the abundance of Oscillospira, which reduces the risk of obesity. Due to the enrichment of cell−cell junction proteins and the lack of mucin, the regulation of gut microecology by bovine MFGs was not readily apparent. In short, this study paves the way for the development of functional infant formula.

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“… 123 , 125 Moreover, their results showed that chitosan microspheres can eradicate H. pylori through adhesion and are subsequently eliminated from the gastrointestinal tract. 126 Based on this idea, Adebisi et al also designed a clarithromycin-loaded chitosan hybrid microsphere and found that chitosan causes a significantly high adhesion of the microsphere to H. pylori . 124 …”

Section: Nanoparticlesmentioning

confidence: 99%

Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives

Lai

Wei

et al. 2022

Gut Microbes

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Helicobacter pylori ( H. pylori ) is the main cause of gastric adenocarcinoma. However, the traditional antibiotic treatment of H. pylori is limited due to increased antibiotic resistance and low efficacy; low drug delivery efficiency and difficulties in eradicating H. pylori that is present intracellularly or in biofilms cause further setbacks. Biomaterials that can protect drugs against stomach acid, target lesions, control drug release, destroy biofilms, and exhibit unique antibacterial mechanisms and excellent biocompatibility have emerged as attractive tools for H. pylori eradication, particularly for drug-resistant strains. Herein, we review the virulence mechanisms, current drug treatments, and antibiotic resistance of H. pylori strains. Furthermore, recent advances in the development of biomaterials, including nanoparticles (such as lipid-based nanoparticles, polymeric nanoparticles, and inorganic nanoparticles), microspheres, and hydrogels, for effective and precise therapy of H. pylori and different types of therapeutic mechanisms, as well as future perspectives, have also been summarized.

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Orally administrated chitosan microspheres bind Helicobacter pylori and decrease gastric infection in mice

Cited by 24 publications

References 92 publications

A comprehensive evaluation of an animal model for Helicobacter pylori‐associated stomach cancer: Fact and controversy

A comprehensive evaluation of an animal model for Helicobacter pylori‐associated stomach cancer: Fact and controversy

Effects of Human, Caprine, and Bovine Milk Fat Globules on Microbiota Adhesion and Gut Microecology

Biomaterials for Helicobacter pylori therapy: therapeutic potential and future perspectives

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