Orange Peel Extracts: Chemical Characterization, Antioxidant, Antioxidative Burst, and Phytotoxic Activities

Erukainure, Ochuko L.; Oa, Ebuehi; M, Iqbal Chaudhary; Mesaik, M. Ahmed; Shukralla, A; Muhammad, Aliyu; Mz, Zaruwa; Elemo, Gloria N.

doi:10.3109/19390211.2016.1150932

Cited by 19 publications

(6 citation statements)

References 8 publications

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“…(n= 6) where a -p<0.0001 between normal and control, b -p<0.01, c-p<0.0001, d-p>0.01 between treated and control groups and e-p<0.001 between methotrexate and flavonoids. [14][15] significant antioxidant [24][25][26][27] antibacterial, 28 antiproliferative activity. 29 In the present study in vitro and in vivo antitumor studies of orange peel flavonoids were conducted.…”

Section: Resultsmentioning

confidence: 99%

Antitumor and Antioxidant Effects of Flavonoid Fraction of Citrus sinensis peel Extract

Shirisha¹,

Mandava²,

Batchu³

et al. 2019

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Background: Cancer is one of the leading causes of death and globally the numbers of cases of cancer are increasing gradually. However, surgeries, chemotherapies have become safer, but these treatments have debilitating side effects. Flavonoids present in the human diet comprise many polyphenolic secondary metabolites with broad-spectrum pharmacological activities including their potential role as anti-cancer agents. Objective: The objective of the present study was to extract, orange peel flavonoids (Orange Peel Extract) and to screen anticancer potential of OPF. Methods: In the present study tryphan blue dye exclusion, clonogenic assay and nuclear damage studies by ethidium bromide staining were performed to estimate in vitro antitumor properties of Orange Peel Extract and subsequently in vivo studies also performed using the Dalton Lymphoma Ascites (DLA) tumor model in Swiss albino mice. Results: In vitro studies revealed the moderate toxicity, high regenerative capacity of Orange Peel Extract and also showed changes in nuclear morphology similar to that of apoptotic cells which is one of the important aspect of an anticancer drug. In vivo studies confirmed the anticancer activity of Orange Peel Extract and has increased the average life span of treated animals and restored the antioxidant enzyme levels and hematological parameters to normal which was comparable to that of standard methotrexate. Conclusion: Overall, these findings have proved that out of the two doses (50mg/kg bw and 200mg/kg bw) employed for the study lower dose (50mg/kg) was found to be more effective than higher dose (200mg/ kg). Hence flavonoid fraction of orange peels can be the better alternative to treat cancer.

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Section: Resultsmentioning

confidence: 99%

Antitumor and Antioxidant Effects of Flavonoid Fraction of Citrus sinensis peel Extract

Shirisha¹,

Mandava²,

Batchu³

et al. 2019

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“…The peel and seeds are the major non-edible wastes of the fruit. The peel is traditionally used to treat symptoms of indigestion and respiratory tract inflammation [ 22 ]. Pharmacological evidence shows the potential of its peel and seeds to potentiate glycemic control, ameliorate diabetes and obesity, reduce tissue inflammation and protect against tissue oxidative damage.…”

Section: Ethnomedicinal Pharmacological and Phytochemical Properties ...mentioning

confidence: 99%

Antioxidative, Metabolic and Vascular Medicinal Potentials of Natural Products in the Non-Edible Wastes of Fruits Belonging to the Citrus and Prunus Genera: A Review

Chukwuma

2024

Plants

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Diabetes mellitus and related metabolic and vascular impairments are notable health problems. Fruits and vegetables contain phenolics that are beneficial to metabolic and oxidative health and useful in preventing associated disease. Scientific evidence has shown that some bioactive phenolics are more abundant in the non-edible parts (especially the peels) of many fruits than in their respective edible tissues. Fruits belonging to the Citrus and Prunus genera are commonly consumed worldwide, including in South Africa, and their non-edible wastes (peel and seed) have been shown to have antioxidative, metabolic and vascular pharmacological potentials and medicinal phytochemistry. It is therefore imperative to evaluate the pharmacological actions and phytochemical properties of the non-edible wastes of these fruits and understand how they could potentially be of medicinal relevance in oxidative, metabolic and vascular diseases, including diabetes, oxidative stress, obesity, hypertension and related cardiovascular impairments. In the absence of a previous review that has concomitantly presented the medicinal potentials of fruits wastes from both genera, this review presents a critical analysis of previous and recent perspectives on the medicinal potential of the non-edible wastes from the selected Citrus and Prunus fruits in metabolic, vascular and oxidative health. This review further exposes the medicinal phytochemistry, while elucidating the underlying mechanisms through the fruit wastes potentiates their therapeutic effects. A literature search was carried out on “PubMed” to identify peer-reviewed published (mostly 2015 and beyond) studies reporting the antidiabetic, antioxidative, antihypertensive, anti-hyperlipidemic and anti-inflammatory properties of the non-edible parts of the selected fruits. The data of the selected studies were analyzed to understand the bioactive mechanisms, bioactive principles and toxicological profiles. The wastes (seed and peel) of the selected fruits had antioxidant, anti-obesogenic, antihypertensive, anti-inflammatory, antidiabetic and tissue protective potentials. Some phenolic acids and terpenes, as well as flavonoids and glycosides such as narirutin, nobiletin, hesperidin, naringin, naringenin, quercetin, rutin, diosmin, etc., were the possible bioactive principles. The peel and seed of the selected fruits belonging to the Citrus and Prunus genera are potential sources of bioactive compounds that could be of medicinal relevance for improving oxidative, metabolic and vascular health. However, there is a need for appropriate toxicological studies.

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“…Orange tree is the most widely cultivated fruit tree in the world, contributing approximately 60% of the 100 Mt per year of citrus produced globally (Erukainure et al 2016). The orange juice industry produces 30 Mt of waste annually (Donoso et al 2022).…”

Section: Bio-jetmentioning

confidence: 99%

Application of waste biomass for the production of biofuels and catalysts: a review

Quevedo-Amador,

Escalera-Velasco,

Arias

et al. 2024

Clean Techn Environ Policy

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Sustainable development is imperative, and the worldwide energy production must focus on the transition from petroleum derivatives to biomass-based biofuels and bioproducts to achieve a bio-based economy. The global interest in the processing of waste biomass to obtain bio-based products is continuously increasing. However, biorefineries have not yet been consolidated. The effective conversion of biomass components for the generation of value-added biochemicals and biofuels is a determining factor for the economic success of biorefineries. Therefore, exhaustive research has been performed to consolidate the biorefinery industry. This review summarizes the current advances in liquid biofuel production and solid catalysts prepared from waste biomass, as well as their advantages, drawbacks, and statistical data. It offers an extensive perspective, covering conventional methods and cutting-edge techniques such as biochemical and thermochemical biomass conversion technologies (e.g., hydrolysis, fermentation, pyrolysis, and gasification) to produce bioalcohols, biodiesel, renewable diesel, bio-jet, and bio-oil. In addition, the preparation of heterogeneous catalysts using residual biomass and different synthesis routes and their role in biofuel production were analyzed. This review contributes to the analysis of the importance of identifying and valorizing a wide spectrum of raw materials (i.e., urban, forestry, industrial, and agricultural) that have the potential to be used as catalyst precursors and biofuel feedstock. Finally, a techno-economic analysis, the main challenges, and the future scope of the diverse methods used to prepare biofuels and catalysts are discussed. This review examines numerous aspects from biomass to catalysts, thus providing relevant information for researchers, students, policymakers, and industry experts. Graphical abstract

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Orange Peel Extracts: Chemical Characterization, Antioxidant, Antioxidative Burst, and Phytotoxic Activities

Cited by 19 publications

References 8 publications

Antitumor and Antioxidant Effects of Flavonoid Fraction of Citrus sinensis peel Extract

Antitumor and Antioxidant Effects of Flavonoid Fraction of Citrus sinensis peel Extract

Antioxidative, Metabolic and Vascular Medicinal Potentials of Natural Products in the Non-Edible Wastes of Fruits Belonging to the Citrus and Prunus Genera: A Review

Application of waste biomass for the production of biofuels and catalysts: a review

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