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Yanoff, Myron; Sassani, Joseph W.

doi:10.1016/b978-0-323-04232-1.50019-0

Cited by 5 publications

(10 citation statements)

References 346 publications

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“…These granules represent remains of "de-lustering agents" such as titanium, barium or zinc added during fiber fabrication used to reduce the plastic characteristics of the final fabric. 1,5,8,10,11 Synthetic fibers are consistently birefringent when examined under polarized light microscopy. Most synthetic fibers polarize vividly, and many exhibit a rainbow of colors when sectioned obliquely or longitudinally.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and histopathological features of conjunctival “Teddy bear” granuloma: A case series

Bustillo

Valles-Valles

Hernández-Ayuso

et al. 2022

European Journal of Ophthalmology

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Purpose To describe the clinical features, histopathological findings, and prognosis of conjunctival Teddy bear granuloma (TBG) diagnosed in a Mexican ophthalmologic referral center in a period of 64 years. Methods We reviewed clinical and histopathological material from all patients with documented conjunctival TBG. Patient′s age, gender, location, clinical signs and symptoms, duration, treatment and, specimen size, were evaluated. Formalin-fixed paraffin embedded 5 microns hematoxylin-eosin stained slides and periodic acid-Schiff special stain as well as examination under polarized light microscopy were performed in all cases. Results A total of 5 conjunctival TBG were collected. The ages of the patients ranged between 2 and 11 with a mean of 6 years. Female to male ratio was 4:1. The right inferior fornix was involved in 4 cases (80%) with clinical diagnosis of conjunctival mass of unknown etiology. Treatment consisted of surgical removal by slit-lamp biomicroscopy (3 cases) and in the operating room (2 cases). No complications were informed in a short follow-up period. Histopathologically, numerous cross-sections of synthetic and non-synthetic fibers surrounded by multinucleated foreign body giant cells, epithelioid histiocytes, lymphocytes, plasma cells and sparse neutrophils were seen. Polarization light microscopy demonstrated numerous birefringent colorful foreign fibers. The follow-up period of the patients ranged between 1 and 32 weeks with a mean of 10 weeks. Conclusions Most patients with TBG are children with vague, non-specific symptoms troubling precise clinical diagnosis. Treatment of choice involves surgical excision of the foreign body granuloma followed by topical corticosteroids. All surgical specimens obtained must be sent for histopathological examination. Special awareness is recommended during COVID-19 pandemic lockdown to prevent potential exposure to fibers that may cause conjunctival TBG.

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Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8] Children were affected in all our cases as noticed by previous authors. 1,4,5,[8][9][10][11] Mean age of our patients was 6 years, the majority female with unilateral involvement. Inferior conjunctival fornix was the most common location.…”

Section: Discussionmentioning

confidence: 99%

Clinical and histopathological features of conjunctival “Teddy bear” granuloma: A case series

Bustillo

Valles-Valles

Hernández-Ayuso

et al. 2022

European Journal of Ophthalmology

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“…It may be primary, secondary, or metastatic. Tumors of the lacrimal drainage system may be epithelial (73%)[ 1 ] or nonepithelial and either benign or malignant. Among nonepithelial tumors, lymphoproliferative tumors account for approximately 2%–8% of lacrimal sac tumors and more commonly arise secondary to systemic spread in a patient with leukemia or lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…Most Lacrimal neoplasms are epithelial in origin, and squamous cell carcinoma is the most common one. [ 1 ] Lymphomas of the lacrimal sac are rare,[ 2 ] and the primary one is rarer. The vast majority of lacrimal lymphomas are either secondary or metastatic.…”

Section: Introductionmentioning

confidence: 99%

“…Histopathologically, non-Hodgkin's B-cell lymphomas are the most familiar type of lymphoma in the lacrimal drainage system. [ 1 ] In the UK, diffuse large B-cell lymphoma (DLBCL) and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) are common histological types of primary lacrimal sac lymphoma. [ 3 ] But in Japan, the most reported primary lymphoma in the lacrimal sac is DLBCL.…”

Section: Introductionmentioning

confidence: 99%

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Diffuse large cell lymphoma of the lacrimal sac may mimic as acute dacryocystitis

Roy¹,

Nuruddin²,

Hoque³

2023

Oman Journal of Ophthalmology

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A 36-year-old male patient presented with a firm swelling in the left lacrimal sac region with a history of recurrent episodes of acute dacryocystitis, which partly resolved with systemic antibiotics. Computed tomography showed diffuse soft tissue mass without bony erosion in the same area. Incisional biopsy confirmed diffuse large cell lymphoma of non-Hodgkin's type by histopathology and immunohistochemistry. Oncologists did not detect systemic involvement, and the patient received six cycles of cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisolone (CHOP). Epiphora was resolved, and no recurrence of the lesion was seen with subsequent dacryocystorhinostomy with intubation and was in good health for up to 3 years of follow-up. Although primary lacrimal sac lymphoma is a rare entity, high suspicion, and prompt action in atypical cases can save lives from aggressive diffuse large cell lymphoma.

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Identification and molecular characterization of two recurrent missense mutations in the RS1 gene in two families with X‐linked retinoschisis from North India

Chatterjee

Gupta

Kirola

et al. 2023

American J of Med Genetics Pt A

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X‐linked retinoschisis (XLR) is a rare medical condition that involves in the splitting of neurosensory layers and the impairment of vision in the retina. In majority of the XLR cases, pathogenic variants in Retinoschisin 1 (RS1) gene have been implicated in males with an early age of onset during early childhood. In the present study, we have recruited two North Indian families having multiple affected male members, who were diagnosed with XLR. The entire protein‐coding region of RS1 was screened by PCR‐Sanger sequencing and two recurrent pathogenic variants (p.I81N and p.R102Q) were unraveled. The in vitro study of these variants demonstrated the aggregation of mutant RS1 within the endoplasmic reticulum. Furthermore, mutant forms of this protein showed significant intracellular retention, which was evident by the absence of retinoschisin protein fractions in the extracellular media. These inferences were also supported by extensive bioinformatics analysis of the mutants, which showed dramatic conformational changes in the local structure of retinoschisin. Thus, our study suggests that the identified pathogenic variants interfere with proper protein folding, leading to anomalous structural changes ultimately resulting in intracellular retention of retinoschisin within the retina.

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Cited by 5 publications

References 346 publications

Clinical and histopathological features of conjunctival “Teddy bear” granuloma: A case series

Clinical and histopathological features of conjunctival “Teddy bear” granuloma: A case series

Diffuse large cell lymphoma of the lacrimal sac may mimic as acute dacryocystitis

Identification and molecular characterization of two recurrent missense mutations in the RS1 gene in two families with X‐linked retinoschisis from North India

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