Orbital lymphoma: Is it necessary to treat the entire orbit?

Pfeffer, M. Raphael; Rabin, Tatiana; Tsvang, L.; Goffman, Janna; Rosen, Nachum; Symon, Zvi

doi:10.1016/j.ijrobp.2004.03.039

Cited by 74 publications

(24 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although MALT lymphomas respond well to surgical removal, for localized disease in the OOA radiotherapy is the treatment of choice. A dose of 30-35 Gy has been reported to be sufficient to provide local control and cure of disease localized to the OOA and is associated with excellent survival [8]. Radiation complications such as keratitis from dry eye, cataracts, and radiation retinopathy can occur.…”

Section: Commentsmentioning

confidence: 99%

A case of an enlarged medial rectus muscle

2008

View full text Add to dashboard Cite

show abstract

Section: Commentsmentioning

confidence: 99%

A case of an enlarged medial rectus muscle

2008

View full text Add to dashboard Cite

show abstract

“…28,58,[62][63][64][65] The whole orbit should be treated. 66 For anterior orbital lesions in the conjunctiva, a direct anterior beam with orthovoltage (250 kV), 4-6 MV photons, or electron beam can be used. A small lead shield suspended in front of the lens can reduce the lens dose to under 5-10%, 67 to minimize the risk of cataract formation to 10% or less.…”

Section: Malt Lymphoma Of Other Sitesmentioning

confidence: 99%

Radiation therapy for localized low-grade non-Hodgkin's lymphomas

Tsang

Gospodarowicz

2005

Hematol. Oncol.

View full text Add to dashboard Cite

The most common low grade B-cell non-Hodgkin's lymphomas are follicular lymphomas, and extranodal marginal zone lymphomas, also known as mucosa-associated lymphoid tissue (MALT) lymphomas. Localized presentations of follicular lymphoma occur in 20-30% of cases, while for MALT lymphomas, stage I-II disease presentations occur in 70-90%. These are radiation-sensitive lymphomas. Following moderate dose local radiation treatment (30-35 Gy) for these stage I and II low grade lymphomas, the clinical results indicate long-term local control and possible cure. While local control is achieved with minimal morbidity with involved-field radiation therapy, a significant proportion of patients relapse with systemic disease outside of radiation fields. For follicular lymphoma, this occurs in approximately 50% of patients after 15 years, and for non-gastric MALT lymphoma, 30-40% after 10 years. Although patients with relapsed systemic disease are not curable with chemotherapy, the disease often behaves in an indolent fashion and prolonged survival is observed. For gastric MALT lymphomas, radiation therapy is indicated in patients whose lymphoma did not respond to Helicobacter pylori eradication therapy, or in gastric lymphoma not related to this microorganism. The subject of causative agents responsible for non-gastric MALT lymphomas is under active study and the identification of putative microorganisms will lead to improved treatment strategies for these unusual lymphomas, similar to the success in gastric lymphomas over the last decade.

show abstract

“…The incidence of metastases to the orbit among patients with breast carcinoma has been reported to vary between 8 % and 10 % [3]. Breast carcinoma is the most common primary cancer to cause metastases in the orbit [4]. A breast cancer patient can present primary with a metastatic retro bulbar tumour [4].…”

Section: Discussionmentioning

confidence: 99%

“…Breast carcinoma is the most common primary cancer to cause metastases in the orbit [4]. A breast cancer patient can present primary with a metastatic retro bulbar tumour [4]. diagnosis of this disease entity requires a high clinical suspicion.…”

Section: Discussionmentioning

confidence: 99%

“…Anytime, when ophthalmologist has a patient with unilateral painful ophthalmopathy, proptosis and neuroparalitic keratitis, orbital metastases must be considered and detailed multidisciplinary team examinations performed [8,9]. Lymphoma or other tumor in the orbit may have an infiltrative pattern or discrete nodules, and it may involve an orbital soft tissue [3,4]. Patients with orbital metastases were found to have widespread metastatic disease elsewhere.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Orbital metastases from breast cancer: a case report

Janicijevic-Petrovic

Šarenac

Srećković

et al. 2011

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

We present a patient with a corneal ulcer of the right eye, with eye protrusion and without anamnesis of cancer. On CT examination there was a bulky soft tissue mass in the cranial aspect of the right orbit, without increasing in signal intensity after injection of contrast. Open biopsy revealed undifferentiated tissue that stained strongly positive for breast carcinoma, confirming the diagnosis of metastases of breast carcinoma.

show abstract

Orbital lymphoma: Is it necessary to treat the entire orbit?

Cited by 74 publications

References 15 publications

A case of an enlarged medial rectus muscle

A case of an enlarged medial rectus muscle

Radiation therapy for localized low-grade non-Hodgkin's lymphomas

Orbital metastases from breast cancer: a case report

Contact Info

Product

Resources

About