Orbital presentation of Rosai–Dorfman disease

Yataco-Vicente, J.A.; Araujo‐Castillo, Roger V.; Fuentes, M.H. López

doi:10.1016/j.oftale.2018.07.007

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…Chemotherapeutic approaches have also been used to treat both diseases,[ 4 7 ] but they could not be assayed in this particular case because of the general status of the patient.…”

Section: Discussionmentioning

confidence: 99%

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Orbital histiocytosis with systemic involvement

Civit

Godoy

Conde

et al. 2020

Saudi Journal of Ophthalmology

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A 70-year-old male presented with orbital masses affecting the muscular cone. His past medical history was notable for diabetes mellitus, ischemic cardiopathy, sleep-apnea syndrome, and multiple serous effusions. The first biopsy specimen of affected orbital tissue revealed fibrohistiocytic infiltration resembling xanthogranuloma or Erdheim–Chester disease (ECD). An ulterior biopsy of affected orbital tissue showed lymphocyte emperipolesis with immunopositivity for CD68 and S100 but negative staining for CD1a marker, strongly suggesting Rosai–Dorfman disease (RDD). Afterward, pericardium and peritoneal effusions resulted in constrictive pericarditis and retroperitoneal fibrosis, respectively. The absence of distinctive clinical features made the diagnosis especially challenging. Attempts to control the disease using corticosteroids, radiation, orbital surgery, and interferon were unsuccessful. Aggressive treatments such as chemotherapy were not considered appropriate due to the general deterioration of our patient. Although the possibility of two concurrent diseases (e.g., systemic ECD and orbital RDD) cannot be discarded, we interpreted the orbital findings as likely due to RDD, and the entire condition of our patient as an extranodal RDD with atypical clinicopathological findings and outcome.

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“…Chemotherapeutic approaches have also been used to treat both diseases,[ 4 7 ] but they could not be assayed in this particular case because of the general status of the patient.…”

Section: Discussionmentioning

confidence: 99%

“…[ 5 6 ] Although the disease is usually self-limiting, patients may suffer relapses and perish due to vital organ compression. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

Orbital histiocytosis with systemic involvement

Civit

Godoy

Conde

et al. 2020

Saudi Journal of Ophthalmology

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“…[3] Infiltrations of the conjunctiva/subconjunctiva, lacrimal tract, cornea, epibulbar and uveal tract, ciliary body as well as of the optic nerve, have been reported. [21920] In this location, RDD could mimic lymphoma and lacrimal gland tumors.…”

Section: Discussionmentioning

confidence: 99%

Orbital Rosai–Dorfman disease: A case report and literature review

Al-Maghrabi

Elnaggar

Alamri

et al. 2019

J Microsc Ultrastruct

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A 53-year-old male presented with dropping of the right eyelid associated with decreased visual acuity for 4 months. He also complained of vertical diplopia especially when looking down. Ophthalmological examination revealed right blepharospasm associated with right hypertropia. There was palpable mass at the inferomedial aspect of the right eye. Magnetic resonance imaging revealed abnormal signal intensity in the right orbit inferior aspect occupying the orbital floor and measured 2.7 cm × 2.5 cm × 1.2 cm and showed enhancement on the postcontrast study. The patient underwent complete excision of the tumor. Histological examination of the mass revealed histiocytic proliferation with emperipolesis, with positive S100, positive CD68, and negative CD1a staining. These histological and immunohistochemical features are consistent with extranodal Rosai–Dorfman disease. There was no complication or recurrence after the complete excision.

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