Orbital Tumour as Initial Manifestation of Acute Myeloid Leukemia: Granulocytic Sarcoma: Case Report

Maka, Erika; Lukáts, Olga; Tóth, Jeannette; Fekete, S.

doi:10.1007/s12253-008-9028-x

Cited by 19 publications

(10 citation statements)

References 6 publications

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“…Notably, none of the paediatric patients with primary orbital manifestations had leukaemic infiltrates in the retina or choroid, whereas four of six patients with secondary ophthalmic leukaemias had such infiltrates. Taken together, our findings further emphasise the broad clinical spectrum of leukaemic lesions that may manifest in the eye or ocular region,1 3 4 6 7 10 11 and the need to consider leukaemia in the differential diagnosis of patients with proptosis, reduced mobility and/or displacement of the eye 1 4 6…”

Section: Discussionmentioning

confidence: 52%

Clinical and genomic features of adult and paediatric acute leukaemias with ophthalmic manifestations

et al. 2019

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ObjectiveTo describe the clinicopathological and genomic features of nine patients with primary and secondary orbital/ocular manifestations of leukaemia.MethodsAll orbital/ocular leukaemic specimens from 1980 to 2009 were collected from the Danish Register of Pathology. In six cases, medical records and formalin-fixed, paraffin-embedded blocks were available. Three cases from the Department of Pathology, Royal Liverpool University Hospital, were also included. Immunophenotypes and MYB oncoprotein expression were ascertained by immunohistochemistry. Genomic imbalances were analysed with comparative genomic hybridisation arrays and oncogene rearrangements with fluorescence in situ hybridisation.ResultsFour patients had B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) and five had acute myeloid leukaemia (AML). Two patients with BCP-ALL and one with AML had primary orbital manifestations of leukaemia. Common symptoms were proptosis, displacement of the eye, and reduced eye mobility in patients with orbital leukaemias and pain, and reduced visual acuity in patients with ocular leukaemias. All patients with primary orbital lesions were alive up to 18 years after diagnosis. All but one patient with secondary ophthalmic manifestations died of relapse/disseminated disease. ETV6 and RUNX1 were rearranged in BCP-ALL, and RUNX1 and KMT2A in AML. Genomic profiling revealed quiet genomes (0–7 aberrations/case). The MYB oncoprotein was overexpressed in the majority of cases.ConclusionsLeukaemias with and without ophthalmic manifestations have similar immunophenotypes, translocations/gene fusions and copy number alterations. Awareness of the clinical spectrum of leukaemic lesions of the eye or ocular region is important to quickly establish the correct diagnosis and commence prompt treatment.

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Section: Discussionmentioning

confidence: 52%

Clinical and genomic features of adult and paediatric acute leukaemias with ophthalmic manifestations

et al. 2019

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“…15 The common characteristics of orbital MS were proptosis, chemosis, orbital mass, and lid edema. 14 , 16 , 17 Ocular MS in adult AML patients was 10 out of 3,724 (0.3%) in the study, 17 whereas Cavdar et al reported 33 orbito-ocular MS in 133 Turkish children with AML. 18 The Children’s Oncology Group concluded that patients with MS involving orbital and central nervous system (CNS) sites had significantly better survival than patients with non-CNS MS, with CSF leukemia, or without extramedullary leukemia.…”

Section: Discussionmentioning

confidence: 62%

Acute Myeloid Leukemia Transformation from Myelofibrosis Upon Remission of an Orbital Myeloid Sarcoma – A Case Report

Chen

Lin

Hsu

et al. 2021

IMCRJ

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Purpose To report a case of an orbital myeloid sarcoma concurrent with JAK2 mutation myelofibrosis, which rapidly transformed into acute myeloid leukemia upon aggressive treatment. Results A 51-year-old woman had progressive swelling of periorbita for one month. Magnetic resonance imaging demonstrated a well-defined, mild enhanced mass indenting the adjacent right lateral rectus muscle and the globe. Biopsy from anterior orbitotomy revealed an orbital myeloid sarcoma. Bone marrow study showed concurrent myelofibrosis. Although the orbital lesion subsided remarkably under aggressive chemotherapy and radiotherapy, the leukemic transformation was noticed in the third month following the initial presentation. Conclusion This case demonstrated that myeloid sarcoma should be included in the differential diagnosis of orbital diseases, with or without involvement of hematological disorders. Early diagnosis and aggressive treatment as for AML are crucial as the prognosis is usually poor for adult orbital MS.

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“…The direct infiltration of the orbits in leukemia can present with proptosis, chemosis, lid edema, intra‑retinal macular or sub‑hyaloid hemorrhages, cotton wool spots, blurring of vision, diplopia, palsies of the extra‑ocular muscle, or papilledema due to the increased intracranial pressure 5. Most cases of orbital involvement in AML present with unilateral proptosis,7–11 and few case reports have reported bilateral orbital involvement as an initial manifestation of AML 12,13…”

Section: Discussionmentioning

confidence: 99%

<p>Unilateral Proptosis As An Initial Sign Of Acute Myeloid Leukemia In A Child: A Case Report</p>

Almalki¹,

Alotaibi²,

Jabr³

et al. 2019

IMCRJ

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Granulocytic sarcoma (chloroma) is a rare malignant solid tumor representing an extramedullary manifestation of acute myeloid leukemia (AML). Rarely, a chloroma can develop as the sole manifestation and its appearance may precede the systemic manifestations of acute myelocytic leukemia by months to years. We report a rare case of unilateral orbital mass presenting with progressive proptosis involving left globe in an otherwise healthy child, and give a brief overview of the literature about this unusual presentation. Leukemic infiltration should be considered in the differential diagnosis of orbital masses and proptosis even in the absence of systemic manifestations of AML. Early detection and management are crucial to preserve vision and prevent complications.

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Orbital Tumour as Initial Manifestation of Acute Myeloid Leukemia: Granulocytic Sarcoma: Case Report

Cited by 19 publications

References 6 publications

Clinical and genomic features of adult and paediatric acute leukaemias with ophthalmic manifestations

Clinical and genomic features of adult and paediatric acute leukaemias with ophthalmic manifestations

Acute Myeloid Leukemia Transformation from Myelofibrosis Upon Remission of an Orbital Myeloid Sarcoma – A Case Report

<p>Unilateral Proptosis As An Initial Sign Of Acute Myeloid Leukemia In A Child: A Case Report</p>

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