Orbitale Metastase als „Erstmanifestation“ eines typischen Karzinoids der Lunge

Schmack, Ingo; Breil, P; Kriwalsky, M.S.; Kunkel, Martin; Tischoff, Iris

doi:10.1055/s-0032-1328614

Cited by 3 publications

(1 citation statement)

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“…Until 2005 the largest series on NET orbital metastases (n = 13) along with a comprehensive literature review was published by Mehta J. et al, 14 accounting for 45 cases in total. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] Since then other 50 cases have been reported, 4,5,9,[35][36][37][38][39][40][41][42][43][44] with the largest series to date being published by Kamieniarz L. et al in 2019, 13 accounting for 27 patients.…”

Section: Discussionmentioning

confidence: 99%

Orbital metastasis from neuroendocrine tumour: Case report and literature review

Albanese

Harieaswar

Sampath

2021

European Journal of Ophthalmology

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Orbital metastases from neuroendocrine tumour are rare entities. An incidental finding of orbital metastasis originating from neuroendocrine tumour is presented in the context of a comprehensive review of all case reports and series published to date. Demographics, clinical features, diagnostic work-up, treatment and prognostic data from the published literature are discussed. Ninety-five patients with orbital metastases from neuroendocrine tumours have been reported so far. Average age at presentation is 63.8 years (range 25–86), with no significant gender predominance. Gastrointestinal tract is the most common site of primary neuroendocrine tumours (62–85%). Typical presentation includes proptosis (80–85%) and diplopia (27–62%) in patients with known primary neuroendocrine tumour elsewhere. Histological subtype and presence of metastases seem to be important prognostic factors. Incidental finding of neuroendocrine tumour mestastases in asymptomatic patients with unknown primary disease is uncommon. In such cases, orbital biopsy and structural and functional imaging are essential to establish a diagnosis and stage the disease.

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