Order and disorder in intermediate filament proteins

Kornreich, Micha; Avinery, Ram; Malka-Gibor, Eti; Laser-Azogui, Adi; Beck, Roy

doi:10.1016/j.febslet.2015.07.024

Cited by 56 publications

(70 citation statements)

References 204 publications

(286 reference statements)

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“…The GFAP mAb epitope was mapped to the rod domain in the C-terminus of the protein (Sigma-Aldrich Technical Service, personal communication). The rod domain is highly conserved in size, sequence and secondary structure (Chernyatina et al, 2015; Kornreich et al, 2015; Strelkov et al, 2002). Within the rod domain is a highly conserved sequence known as the intermediate filament consensus sequence present in all IFPs (Hatzfeld and Weber, 1992).…”

Section: Discussionmentioning

confidence: 99%

Müller glia reactivity follows retinal injury despite the absence of the glial fibrillary acidic protein gene in Xenopus

Luna

Aruck

et al. 2017

Developmental Biology

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Intermediate filament proteins are structural components of the cellular cytoskeleton with cell-type specific expression and function. Glial fibrillary acidic protein (GFAP) is a type III intermediate filament protein and is up-regulated in glia of the nervous system in response to injury and during neurodegenerative diseases. In the retina, GFAP levels are dramatically increased in Müller glia and are thought to play a role in the extensive structural changes resulting in Müller cell hypertrophy and glial scar formation. In spite of similar changes to the morphology of Xenopus Müller cells following injury, we found that Xenopus lack a gfap gene. Other type III intermediate filament proteins were induced following rod photoreceptor ablation and retinal ganglion cell axotomy. The recently available X. tropicalis and X. laevis genomes indicate a small deletion most likely resulted in the loss of the gfap gene during evolution. Lastly, a survey of representative species from all three extant amphibian orders including the Anura (frogs, toads), Caudata (salamanders, newts), and Gymnophiona (caecilians) suggests that deletion of the gfap locus occurred after the common ancestor of the Anura and Caudata. Our results demonstrate that extensive changes in Müller cell morphology following retinal injury do not require GFAP in Xenopus, and other type III intermediate filament proteins may be involved in the gliotic response.

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Section: Discussionmentioning

confidence: 99%

Müller glia reactivity follows retinal injury despite the absence of the glial fibrillary acidic protein gene in Xenopus

Luna

Aruck

et al. 2017

Developmental Biology

View full text Add to dashboard Cite

show abstract

“…parallel α-helices (Chernyatina et al , 2015; Koster et al , 2015). Given the broad expression of IF proteins and the diverse distribution of IF proteins in the body, it has been proposed that their tissue-specialized functions may result from their interaction with tissue-specific binding partners (Herrmann and Aebi, 2004; Capetanaki et al , 2015; Kornreich et al , 2015; Koster et al , 2015). …”

Section: Introductionmentioning

confidence: 99%