Order–order assembly transition-driven polyamines detection based on iron−sulfur complexes

Abstract

Innovative modes of response can greatly push forward chemical sensing processes and subsequently improve sensing performance. Classical chemical sensing modes seldom involve the transition of a delicate molecular assembly during the response. Here, we display a sensing mode for polyamine detection based on an order–order transition of iron–sulfur complexes upon their assembly. Strong validation proves that the unique order–order transition of the assemblies is the driving force of the response, in which the polyamine captures the metal ion of the iron–sulfur complex, leading it to decompose into a metal–polyamine product, accompanied by an order–order transition of the assemblies. This mechanism makes the detection process more intuitive and selective, and remarkably improves the detection efficiency, achieving excellent polyamines specificity, second-level response, convenient visual detection, and good recyclability of the sensing system. Furthermore, this paper also provides opportunities for the further application of the iron–sulfur platform in environment-related fields.

Disposable Saliva Sensors for Early Cancer Diagnosis Using Hyper-Cross-Linked Molecularly Imprinted Polymeric Electrocatalysts

“…In this context, the biogenic polyamine content in humans is considered an essential biomarker for different types of cancers. , For instance, Giskeødegård et al demonstrated that metabolic profiling of spermine could be a promising diagnostic tool to assess the aggressiveness of prostate cancer. Hence, polyamine detection and quantification in physiological fluids are crucial for the timely diagnosis and prognosis of human malignancies . Fluorescence imaging or signaling is the most commonly employed method for detecting polyamines. − However, it is invasive and complex and is not deliverable.…”

“…Hence, polyamine detection and quantification in physiological fluids are crucial for the timely diagnosis and prognosis of human malignancies. 10 Fluorescence imaging or signaling is the most commonly employed method for detecting poly-amines. 11−13 However, it is invasive and complex and is not deliverable.…”

“…Fluorescence imaging or signaling is the most commonly employed method for detecting polyamines. − However, it is invasive and complex and is not deliverable. Other methods include spectroscopy, colorimetry, or electrochemical techniques. ,− However, these methods present several challenges, including limited sensitivity, low specificity, operational stability, high cost, and/or deliverability. Furthermore, invasive testing protocols and failure to analyze complex physiological fluids hinder their practical applications …”