Organ and tissue-dependent effect of resveratrol and exercise on antioxidant defenses of old mice

Tùng, Bùi Thanh; Rodríguez-Bies, Elisabet; Thanh, Hai Nguyen; Le-Thi-Thu, Huong; Navas, Plácido; Sánchez, Verónica Adriana Galván; López-Lluch, Guillermo

doi:10.1007/s40520-015-0366-8

Cited by 49 publications

(36 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, in previous studies, more of the 80% of age-related changes in gene expression found in skeletal muscle were partially or completely suppressed by early onset of CR in mice (Lee et al 1999). These different results probably indicate an age-dependent effect of CR, as we have found in murine models (Rodriguez-Bies et al 2015;Tung et al 2015b).…”

Section: Mitochondrial Activity and Ros Production Are Modulated By Crmentioning

confidence: 52%

“…These discrepancies could be due to differences in the amount of time under CR or the degree of CR which can play an important role in nutrient balance. Further, as has been indicated in antioxidant responses (Rodriguez-Bies et al 2015;Tung et al 2015b), the age of the organism can be an important factor in the importance of each component that responds to CR.…”

Section: Igf-imentioning

confidence: 86%

“…Higher levels of antioxidants do not necessarily indicate a higher antioxidant protection and imbalances produced by the overexpression or higher activity of one antioxidant enzyme must be taken into consideration. Besides the important number of studies that indicate a modulation of antioxidant activities in cells and organs by CR, this effect seems to be organ dependent and studies designed to clarify how ageing and CR affect antioxidant enzymes in each individual tissue and organ must be performed (Ji et al 1990;Tung et al 2015b).…”

Section: Antioxidant Activities In Ageing and Crmentioning

confidence: 99%

“…; Tung et al . b ), the age of the organism can be an important factor in the importance of each component that responds to CR.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Calorie restriction as an intervention in ageing

López-Lluch

Navas

2016

The Journal of Physiology

Self Cite

238

162

View full text Add to dashboard Cite

Ageing causes loss of function in tissues and organs, is accompanied by a chronic inflammatory process and affects life‐ and healthspan. Calorie restriction (CR) is a non‐genetic intervention that prevents age‐associated diseases and extends longevity in most of the animal models studied so far. CR produces a pleiotropic effect and improves multiple metabolic pathways, generating benefits to the whole organism. Among the effects of CR, modulation of mitochondrial activity and a decrease in oxidative damage are two of the hallmarks. Oxidative damage is reduced by the induction of endogenous antioxidant systems and modulation of the peroxidability index in cell membranes. Mitochondrial activity changes are regulated by inhibition of IGF‐1 and Target of Rapamycin (TOR)‐dependent activities and activation of AMP‐dependent kinase (AMPK) and the sirtuin family of proteins. The activity of PGC‐1α and FoxO is regulated by these systems and is involved in mitochondria biogenesis, oxidative metabolism activity and mitochondrial turnover. The use of mimetics and the regulation of common factors have demonstrated that these molecular pathways are essential to explain the effect of CR in the organism. Finally, the anti‐inflammatory effect of CR is an interesting emerging factor to be taken into consideration. In the present revision we focus on the general effect of CR and other mimetics in longevity, focusing especially on the cardiovascular system and skeletal muscle.

show abstract

Section: Mitochondrial Activity and Ros Production Are Modulated By Crmentioning

confidence: 52%

Section: Igf-imentioning

confidence: 86%

Section: Antioxidant Activities In Ageing and Crmentioning

confidence: 99%

“…; Tung et al . b ), the age of the organism can be an important factor in the importance of each component that responds to CR.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Calorie restriction as an intervention in ageing

López-Lluch

Navas

2016

The Journal of Physiology

Self Cite

238

162

View full text Add to dashboard Cite

show abstract

“…Exercise can also act as a mild stressor that promotes adaptations leading to antioxidant defense system fortification, improved mitochondrial function, and induced redox remodeling (Cobley et al 2015; Navarro et al 2004; Ristow and Schmeisser 2014; Tung et al 2015). …”

Section: Antioxidant Intake and Moderate Exercise As Interventionsmentioning

confidence: 99%

The influence of vitamins E and C and exercise on brain aging

Mock

Chaudhari

Sidhu

et al. 2017

Experimental Gerontology

View full text Add to dashboard Cite

Age-related declines in motor and cognitive function have been associated with increases in oxidative stress. Accordingly, interventions capable of reducing the oxidative burden would be capable of preventing or reducing functional declines occurring during aging. Popular interventions such as antioxidant intake and moderate exercise are often recommended to attain healthy aging and have the capacity to alter redox burden. This review is intended to summarize the outcomes of antioxidant supplementation (more specifically of vitamins C and E) and exercise training on motor and cognitive declines during aging, and on measures of oxidative stress. Additionally, we will address whether co-implementation of these two types of interventions can potentially further their individual benefits. Together, these studies highlight the importance of using translationally-relevant parameters for interventions and to study their combined outcomes on healthy brain aging.

show abstract

Detection of synergistic effect of superoxide dismutase and jujubosides on scavenging superoxide anion radical by capillary electrophoresis

Chen

2019

Biomedical Chromatography

View full text Add to dashboard Cite

A new capillary electrophoresis method was developed to study the synergistic effect of superoxide dismutase and jujuboside A or B on scavenging superoxide anion radical in serum matrix respectively, in which superoxide anion radical was generated from pyrogallol autoxidation. The electrophoresis conditions, and the factors affecting the productive rate of purpurogallin, such as pyrogallol autoxidation product and the activity of superoxide dismutase, were optimized. Under optimal conditions, the content of superoxide dismutase in Gibco newborn calf serum was 7.06 mg/L, RSD was 2.01% and the average recovery was 98.4%. The values of IC 50 for jujuboside A and B in the serum matrix were 157.67 and 31.60 mg/L respectively, and they both had synergy on scavenging superoxide anion radical with superoxide dismutase, but there was no the dose-dependency on this synergy. KEYWORDS capillary electrophoresis, jujuboside a and B, superoxide anion radical, superoxide dismutase, synergy

show abstract

Organ and tissue-dependent effect of resveratrol and exercise on antioxidant defenses of old mice

Abstract: Our data suggest that physical activity and resveratrol may be of great importance for the prevention of age-related diseases, but that their organ-dependent effect must be taken into consideration to design a better intervention.

Cited by 49 publications

References 37 publications

Calorie restriction as an intervention in ageing

Calorie restriction as an intervention in ageing

The influence of vitamins E and C and exercise on brain aging

Detection of synergistic effect of superoxide dismutase and jujubosides on scavenging superoxide anion radical by capillary electrophoresis

Contact Info

Product

Resources

About