Organ: Body weight ratios for liver, kidneys and spleen of laboratory animals

Rat, I. Albino; Webster, Stewart H.; Liljegren, Ervin J.; Zimmer, David J.

doi:10.1002/aja.1000810307

Cited by 41 publications

(1 citation statement)

References 31 publications

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“…Livers and spleens were collected, and the index was calculated as the percentage of fresh liver or spleen weight to fresh body weight [17] as follows: …”

Section: Methodsmentioning

confidence: 99%

The effect of immunoregulation of Streptococcus lactis L16 strain upon Staphylococcus aureus infection

Wang

Gong

et al. 2017

BMC Microbiol

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Background Staphylococcus aureus is an important pathogen that causes various infections in medical facilities. However, resistance to multiple drugs has made this infection difficult to manage. Thus, new therapeutic strategies are urgently needed to solve this worldwide public health problem. The Streptococcus lactis L16 strain was isolated from the fermented hot chili sauce. To explore whether it can be used as a protective agent against S. aureus infection, we designed a mouse model of S. aureus infection to evaluate the therapeutic potency of S. lactis. Mice were grouped into pre-(P) and post-(T) S. aureus infection groups following oral administration of S. lactis L16. The protection and treatment effects were assessed by examining body weight, internal organ weight, serum cytokines and intestinal secretory IgA alternations.ResultOral administration of the S. lactis L16 strain reduced the loss of body weight in mice post-infection and alleviated infection-induced hepatomegaly. In particular, the PL16 group (protection with L16) showed more effective resistance to S. aureus than the TL16 group (treatment with L16). The level of serum cytokine interferon gamma following oral administration of the L16 strain was remarkably increased during infection, as were interleukin-4 levels during convalescence. The probiotic L16 strain induced more sIgA production than S. aureus. ConclusionOur data suggest that S. lactis L16 is an effective strain with anti-Staphylococcus activity. By regulating the Th1/Th2 response, S. lactis can effectively reduce lesions from infection, indicating its therapeutic potential in overcoming antibiotic resistance in this mouse infection model that mimics infections observed in humans.

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“…Livers and spleens were collected, and the index was calculated as the percentage of fresh liver or spleen weight to fresh body weight [17] as follows: …”

Section: Methodsmentioning

confidence: 99%