Organ Donation and Transplantation

Allen, Margaret D.; Stillwater, Barbara

doi:10.1002/9781444317459.ch5

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…The autologous tissues used for implantation often differ in size from the injured muscle, which results in inadequate functional regeneration [12]. To solve this limitation of autologous transfers, donated skeletal muscles that correspond to the injured muscle type can replace the source free functional muscle [13,14]. However, the lack of available donor tissue [15] and donor site morbidity [14] are two main limitations of donated skeletal muscle transplantation.…”

Section: Introductionmentioning

confidence: 99%

Direct extrusion of multifascicle prevascularized human skeletal muscle for volumetric muscle loss surgery

Duong,

Dang,

et al. 2023

Preprint

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Volumetric skeletal muscle injuries are prevalent, highlighting the imperative need for scaffolds to facilitate the healing process of such wounds. Human skeletal muscle is composed of multiple fascicles, which are parallel bundles of muscle fibres surrounded by a layer of connective tissue that contains blood vessels and nerves. Replicating these structures presents a considerable challenge. Here, we developed a method to fabricate multifascicle human skeletal muscle scaffolds that mimic the natural structure of human skeletal muscle bundles using a seven-barrel nozzle. To form the core material to generate the fascicle structure, human skeletal myoblasts were encapsulated in Matrigel with calcium chloride. Meanwhile, to create the shell that plays a role as the connective tissue structure, human fibroblasts and human umbilical vein endothelial cells within a mixture of porcine muscle decellularized extracellular matrix and sodium alginate at a 95:5 ratio was used. We assessed four types of extruded scaffolds monolithic-monoculture (Mo-M), monolithic-coculture (Mo-C), multifascicle-monoculture (Mu-M), and multifascicle-coculture (Mu-C) to determine the structural effect of muscle mimicking scaffold. The Mu-C scaffold demonstrated cell proliferation, differentiation, vascularization, mechanical properties, and functionality that were superior to those of the other scaffolds. Furthermore, in anin vivomouse model of volumetric muscle loss, the Mu-C scaffold effectively regenerated the tibialis anterior muscle defect, demonstrating its potential for volumetric muscle transplantation. The multibarrel nozzle device was applied to create functional Mu-C muscle scaffolds that structurally mimicked human skeletal muscle. Our nozzle will be further used to produce other volumetric functional tissues, such as tendons and peripheral nerves.

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Section: Introductionmentioning

confidence: 99%

Direct extrusion of multifascicle prevascularized human skeletal muscle for volumetric muscle loss surgery

Duong,

Dang,

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Organ transplantation is the most favored treatment methodology for patients with end-stage organ malady. The need for organ transplantation is higher than the necessity (Allen and Stillwater, no date;Ganikos, no date;Sarti, 1999;Ahlert and Sträter, 2020) For the transplantation program to be fruitful, mindfulness with respect to organ donation is required and individuals must have an inspirational disposition toward giving organs (Magotra, 2014;Bashir, 2017;Kumar, Kanvinde and Thomas, 2018;Akbulut et al, 2020). While patients with end stage renal disease can be treated by other renal replacement therapies, kidney transplantation is widely recognized as the best cure for both quality of life and cost effectiveness(Organ Donation and Transplantation: Awareness and Roles of healthcare professionals-A Systematic literature Review, 2018; Alan and Kurt, 2019;Ismail, lim and Mahadevan, 2020).…”

Section: Introductionmentioning

confidence: 99%

Awareness on Organ and Body Donation Among Dental and Medical Students

Maheshwaran¹

2020

Biosci. Biotech. Res. Comm

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Cadaveric donation comprises body donation, organ donation that is, taking out organs (heart, lungs, kidneys, liver, pancreas) from brain dead people, as well as tissue donation, meaning taking tissues (skin, corneas, tendons, bone) from brain dead as well as heart dead people.In a broader sense, however, pathologists are involved in cadaveric tissue donation as well as taking tissues from cadavers for diagnostic procedures within the framework of the autopsy (fluids, organs, tissue samples), and to gather material for research and training students and pathology residents (tissues, organs). For cadaveric tissue donation, different ethical and practical issues must be considered, which we will try to review in this paper from the perspective of the pathologist. It is possible to donate your body to medical science after your death. To make the arrangements, contact the anatomical institute of one of the universities in India , as this is a separate process to organ or tissue donor registration. The aim of the study is to evaluate the knowledge and awareness of organ donation. Analytic, longitudinal and quantitative study, conducted in 5 Medical/Dental College in Natal/RN, between November 2019 and January 2020. Survey has been conducted among dental and medical students 105 responses have been received from 5 medical and dental colleges. Regarding the donation structure, there were deficiencies of physical resources (temperature control), materials (mobile radiology) , human resources (nurse technicians) and lack of adequate records and care protocols. In the process of donation, the biggest problems were related to the evaluation stages, brain death diagnosis, maintenance and documentation, with greater proportion of care for the non-donor. 85.4% of the respondents were aware of Organ donation whereas 14.6% of the study population were not aware about organ donation. The primary outcome was intention to donate. Taking a donor card after the interview was a secondary behavioral outcome.

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What are effective approaches to increasing rates of organ donor registration among ethnic minority populations: a systematic review

2013

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ObjectivesTo identify effective interventions to increase organ donor registration and improve knowledge about organ donation among ethnic minorities in North America and the UK.DesignSystematic review.Data SourcesMEDLINE, EMBASE, PsycINFO, CINAHL and Cochrane Central searched up to November 2012, together with four trials databases and the grey literature.Review methodsA systematic search followed by assessment of eligibility and quality. An interpretive and thematic approach to synthesis was undertaken. This examined the nature and delivery of interventions in relation to a range of outcomes: verified registration, changing knowledge and a measured shift towards greater readiness.Results18 studies were included in the review, comprising educational and mass media interventions. Mass media interventions alone reported no significant change in the intention or willingness to register. Educational interventions either alone or combined with mass media approaches were more effective in increasing registration rates, with a strong interpersonal component and an immediate opportunity to register identified as important characteristics in successful change.ConclusionsEffective interventions need to be matched to the populations’ stage of readiness to register. Measured outcomes should include registration and shifts along the pathway towards this behavioural outcome.

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Organ Donation and Transplantation

Cited by 3 publications

References 4 publications

Direct extrusion of multifascicle prevascularized human skeletal muscle for volumetric muscle loss surgery

Direct extrusion of multifascicle prevascularized human skeletal muscle for volumetric muscle loss surgery

Awareness on Organ and Body Donation Among Dental and Medical Students

What are effective approaches to increasing rates of organ donor registration among ethnic minority populations: a systematic review

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