Organ-Protective Effects of Red Wine Extract, Resveratrol, in Oxidative Stress-Mediated Reperfusion Injury

Abstract

Resveratrol, a polyphenol extracted from red wine, possesses potential antioxidative and anti-inflammatory effects, including the reduction of free radicals and proinflammatory mediators overproduction, the alteration of the expression of adhesion molecules, and the inhibition of neutrophil function. A growing body of evidence indicates that resveratrol plays an important role in reducing organ damage following ischemia- and hemorrhage-induced reperfusion injury. Such protective phenomenon is reported to be implicated in decreasing the formation and reaction of reactive oxygen species and pro-nflammatory cytokines, as well as the mediation of a variety of intracellular signaling pathways, including the nitric oxide synthase, nicotinamide adenine dinucleotide phosphate oxidase, deacetylase sirtuin 1, mitogen-activated protein kinase, peroxisome proliferator-activated receptor-gamma coactivator 1 alpha, hemeoxygenase-1, and estrogen receptor-related pathways. Reperfusion injury is a complex pathophysiological process that involves multiple factors and pathways. The resveratrol is an effective reactive oxygen species scavenger that exhibits an antioxidative property. In this review, the organ-protective effects of resveratrol in oxidative stress-related reperfusion injury will be discussed.

Resveratrol Alleviates Inflammatory Responses and Oxidative Stress in Rat Kidney Ischemia-Reperfusion Injury and H2O2-Induced NRK-52E Cells via the Nrf2/TLR4/NF-κB Pathway

“…The pathophysiological mechanisms of IRI are primarily related to proinflammatory reactions, which include inflammatory responses, oxidative stress, and metabolic disorders [1, 3]. Resveratrol (RSV) is a stilbene polyphenolic compound found in grapes, berries, red wines, and peanut skins, and has been studied in many models such as coronary heart disease and diabetes due to its functions in reducing oxidative stress and inflammation [4-6]. In addition, many studies have shown that RSV can have protective effects on organs including the brain [7], heart [8], and kidney in animal IRI models because it reduces oxidative stress and exerts anti-inflammatory and anti-apoptotic effects [9, 10].…”

Resveratrol protects neuronal cells from isoflurane‑induced inflammation and oxidative stress‑associated death by attenuating apoptosis via Akt/p38 MAPK signaling

“…Its sites of action include the cytomembrane, intra-cellular receptor, signaling molecules, enzymes, the oxidative system, the DNA repair system, transcription factors, cell proliferation, the cell cycle, differentiation and cell death (10,11). Cellular signaling pathways convert stimuli to signals.…”

Resveratrol and curcumin as protective agents in an experimental rat model of intestinal ischemia and reperfusion

“…The infiltration (Liu et al 2015). The epithelial-mucosal barrier is fortified by various cell adhesion molecules such as E-cadherin and a mucus layer containing different types of mucin, proteins altered by I/R injury as shown by Turner (Turner 2009).…”

“…Resveratrol has also been suggested to prevent and treat ischemia and reperfusion injury due to its antioxidative activities (Liu et al 2015). Curcumin (1,7-bis(4-hydroxy-3-methoxy-phenyl)-1,6-heptadiene-3, 5 dione) is a yellow-orange dye extracted from the Indian spice turmeric.…”