Organ transplantation and drug eluting stents: Perioperative challenges

Dalal, Aparna

doi:10.5500/wjt.v6.i4.620

Cited by 15 publications

(10 citation statements)

References 83 publications

(102 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Em torno de 64,4% dos pacientes que apresentam essa complicação vascular desenvolvem infarto do miocárdio e outros 8,9% chegam a óbito. Valores preocupantes ainda são encontrados quando se compara a mortalidade nos primeiros seis meses após procedimento, onde taxas de 20,8% são encontradas (Dalal, 2016).…”

Section: Terapia Com Stents Convencionaisunclassified

“…As plataformas usuais são constituídas de aço inoxidável ou ligas metálicas, de comprimento diferenciado, que é definido pelo tamanho da lesão que pode ser corrigida, de forma que a extensão da lesão não ultrapasse o tamanho do stent. Essa base é recoberta por uma camada polimérica durável cuja função é de transportar e permitir a liberação controlada diretamente sobre a lesão no vaso-alvo, com reduzidas concentrações sistêmicas, visando à redução dos efeitos colaterais sistêmicos (Dalal, 2016).…”

Section: Terapia Com Stents Farmacológicosunclassified

“…Nesse sentido, os stents farmacológicos de terceira geração foram desenvolvidos preservando as propriedades das gerações anteriores, mas utilizando novos materiais, plataformas e sistemas de entrega utilizando a tecnologia de polímeros biocompatíveis (bioabsorvíveis) na tentativa de proporcionar maior segurança ao paciente e melhor resultado clínico, através de um melhor gerenciamento dos efeitos adversos em longo prazo desencadeados pelo polímero residual após completa eluição do medicamento (Dalal, 2016).…”

Section: Stents Farmacológicos De Terceira Geraçãounclassified

“…O biolimus A9 é um análogo potencialmente lipofílico, o que lhe possibilita cruzar facilmente a membrana celular, com uma melhor captação pela parede do vaso coronariano, o que lhe confere rápidos efeitos terapêuticos e reduzida exposição sistêmica, acarretando em Research, Society and Development, v. 9, n. 9, e89997049, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i9.7049 um menor risco de imunossupressão e toxicidade. Já o novolimus, é um metabólito ativo, que proporciona eficácia em doses mais reduzidas, atingindo efeitos antiproliferativas em doses de 85 mcg e utilizando uma menor carga de polímero (Dalal, 2016).…”

Section: Stents Farmacológicos De Terceira Geraçãounclassified

See 3 more Smart Citations

Gerações de stents no tratamento da cardiopatia isquêmica

Ferreira¹,

Gusmão²,

Duarte³

et al. 2020

RSD

View full text Add to dashboard Cite

A Doença Arterial Coronariana predispõe o desenvolvimento de doenças isquêmicas cardíacas, sendo uma das principais causas de morbimortalidade em todo mundo. As intervenções coronarianas percutâneas revascularizam o miocárdio por meio da implantação de stents a fim de restabelecer o fluxo sanguíneo nas artérias afetadas. Devido à alta no uso desses dispositivos nos procedimentos percutâneos, bem como as limitações atualmente encontradas, como trombose de stent, reestenose e eventos cardíacos adversos, o objetivo do presente estudo foi analisar as publicações que tratam das diversas gerações de stents no tratamento da doença arterial coronariana, através de uma revisão literária, com busca nas bases Scielo, Pubmed e Sciencedirect. Os stents farmacológicos surgiram como uma alternativa mais segura e eficaz que os stents convencionais, reduzindo episódios de reestenose e eventos cardíacos adversos maiores. No entanto, um maior risco de trombose ligada ao seu uso foi observado. Assim, por meio de um aperfeiçoamento no design, bem como dos materiais utilizados na sua fabricação, diversas gerações de stents farmacológicos foram desenvolvidas, ampliando o acervo terapêutico. Apesar disso, novos estudos ainda são necessários para comprovar sua segurança a longo prazo.

show abstract

Section: Terapia Com Stents Convencionaisunclassified

Section: Terapia Com Stents Farmacológicosunclassified

Section: Stents Farmacológicos De Terceira Geraçãounclassified

See 2 more Smart Citations

Gerações de stents no tratamento da cardiopatia isquêmica

Ferreira¹,

Gusmão²,

Duarte³

et al. 2020

RSD

View full text Add to dashboard Cite

show abstract

“…Implant materials, including vascular stents, directly contact blood, and wall tissues in vivo , which can cause mechanical strain and damage to the implant site. In clinical trials, surface properties of the implant material have been shown to slow endothelialization and cause restenosis and thrombosis . Therefore, more studies are needed to improve our understanding of the surface properties of implant materials, particularly those aimed at developing surface modification strategies that accelerate endothelialization.…”

Section: Introductionmentioning

confidence: 99%

Mussel adhesive protein fused with VE‐cadherin extracellular domain promotes endothelial‐cell tight junctions and in vivo endothelization recovery of vascular stent

et al. 2019

View full text Add to dashboard Cite

Improving the surface properties of vascular stents to accelerate endothelialization in vivo could play an important role in minimizing the risk of late thrombosis. We previously showed that mussel adhesive protein fused with VE‐cadherin extracellular domain (VE‐M) specifically triggered endothelial cell adhesion in vitro. In this study, using stent implants coated with VE‐M, we evaluated the clinical applicability of VE‐M in endothelialization recovery in vivo. First, we explored the effect of VE‐M on hemocompatibility and tight junctions between endothelial cells (ECs) in vitro. VE‐M significantly inhibited platelet adhesion and promoted EC proliferation. Furthermore, VE‐M drastically increased the centralization of F‐actin in human umbilical vein endothelial cells (HUVECs) along the cell contacts, reduced fluorescein isothiocyanate (FITC)—dextran transport across the HUVECs, and elevated expression levels of tight junction proteins (TJPs) in ECs. We then evaluated the effect of VE‐M on endothelialization recovery in vivo through implantation of vascular stents. At 1 day after implantation, stents coated with VE‐M recruited more endothelial progenitor cells (EPCs) than bare stents. At 7 days after implantation, VE‐M stents had a greater coverage of ECs than bare stents. At 1 month after implantation, ECs on VE‐M stents were appropriately elliptical in morphology and closely resembled physiological morphology. Hematoxylin‐eosin (HE) staining revealed little in‐stent neointima formation on VE‐M stents, and SEM images revealed that smooth endothelium had formed on VE‐M stents without adherent platelets. Taken together, these findings indicate that VE‐M accelerates in vivo endothelialization of vascular stents via recruitment of EPCs and promotes endothelium formation and could be explored as a potential bioactive coating for vascular implant. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:94–103, 2020.

show abstract

Application of thromboelastography in diagnosing normal pregnancies and pregnancies with complications

Zhao

Cheng

Huang

et al. 2022

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background This observational study aimed to compare the potential application of thromboelastography (TEG) in diagnosing women with normal pregnancy (NP) and women with threatened abortion (TA), missed abortion (MA), embryo arrest (EA), fetal death (FD), history of abnormal pregnancy (HAP), and antiphospholipid antibody syndrome (AA). Methods According to the relevant clinical criteria, patients were divided into groups, and their blood samples were subjected to TEG. Next, the parameters R, K, α‐angle, MA, LY‐30, G, and coagulation index (CI) were analyzed. Partial correlation analysis was used to analyze correlation between groups of data. LSD‐t test and Dunnett's T3 test were used to analyze continuous variables. Ordinal categorical variables were compared using ordinal logistic regression analysis and estimate odds ratio of risk factors. A receiver operating characteristic (ROC) curve was constructed to detect the ability of TEG to recognize various parameters, and areas under the curve were compared using Delong's test for diagnosing pregnancy‐related diseases. Results MA had a negative effect on the MA parameter in TEG; EA had a negative effect on the MA and G parameters; HAP had a negative effect on the CI parameter and a positive effect on the R parameter; AA had a negative effect on the CI parameter. Compared with that of the NP group, the G of the EA ( p = 0.014) group and the CI of the TA ( p = 0.036) MA ( p = 0.08) EA ( p = 0.026) HAP ( p = 0.000004) and AA ( p = 0.002) groups were reduced. In the ordinal logistic regression analysis, compared with that of the NP group, the high R value of the HAP group accounted for more than that of the NP group (OR = 48.76, p = 0.001); the high K value of the AA group accounted for more than that of the NP group (OR = 17.00, p = 0.023); the angle value distributions of the TA and AA groups were different from that of the NP group (OR = 3.30, p = 0.039; OR = 0.14, p = 0.029); the low MA value of the MA, EA, and HAP groups accounted for more than that of the NP group (OR = 0.16, p = 0.03; OR = 0.26, p = 0.005; OR = 0.11, p = 0.008); and the low CI value of the HAP group accounted for more than that of the NP group (OR = 0.09, p = 0.005). In the ROC analysis, there were no significant differences in the TEG parameters of pregnant women belonging to the NP and TA, NP and MA, NP and EA, NP and FD, NP and HAP, and NP and AA groups ( p > 0.05).

show abstract

Organ transplantation and drug eluting stents: Perioperative challenges

Cited by 15 publications

References 83 publications

Gerações de stents no tratamento da cardiopatia isquêmica

Gerações de stents no tratamento da cardiopatia isquêmica

Mussel adhesive protein fused with VE‐cadherin extracellular domain promotes endothelial‐cell tight junctions and in vivo endothelization recovery of vascular stent

Application of thromboelastography in diagnosing normal pregnancies and pregnancies with complications

Contact Info

Product

Resources

About