Organ Weight: Body Weight Ratios in the Mongolian Gerbil, Meriones unguiculatus

Wilber, Charles G.; Gilchrist, Richard Daniel

doi:10.2307/1351327

Cited by 17 publications

(8 citation statements)

References 6 publications

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“…The organ to body weight ratio gives a proportional size of the organ to body weight. It has been suggested that the use of organ/body weight ratios may be valuable in evaluating the relationship between certain experimental situations and the biological response of a test organism [31]. The liver being the major organ carrying out metabolic and detoxification processes is unique among the body's vital organs in that it can be regenerated.…”

Section: Discussionmentioning

confidence: 99%

Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Activities in Selected Tissues of Rats Fed on Processed Atlantic Horse Mackerel (Trachurus trachurus)

Adeyemi¹,

Osilesi²,

Adebawo³

et al. 2015

ABB

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Trachurus trachurus (locally called kote) is a table fish that has become increasingly important in the Nigerian diet because of its low price. Therefore, this study investigated the effects of processed kote on the activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in selected tissues of weaned male albino rats using standard methods. Chemical analyses were carried out on processed fillet, skin, head & bone (SHB) diets under standard conditions. 40 male rats (40.76 ± 2.42 g) were fed with processed fillet or SHB diets for 14 days to assay for the activities of ALP in harvested samples of brain, liver, kidney, heart, stomach, small intestine and spleen; ALT and AST in the liver and heart. All data were subjected to analysis of variance by Duncan's multiple range test and considered significant at a minimum of p < 0.05. Levels of ALP & AST in the liver, heart, kidney and brain were reduced (p < 0.05) in rats fed on test diets compared with the controls, but within accepted limit. The level of ALT in the kidney, stomach and small intestine were elevated (p < 0.05) compared to the controls, but within the accepted limit. In conclusion, coal smoked fillet and SHB greatly improved healthy growth of the rats, followed by the wood smoked and poached diets. Results suggested that processed kote SHB could * Corresponding author. O. T. Adeyemi et al. 140 be a veritable source of valuable nutrients for human food and animal feed.

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Section: Discussionmentioning

confidence: 99%

Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Activities in Selected Tissues of Rats Fed on Processed Atlantic Horse Mackerel (Trachurus trachurus)

Adeyemi¹,

Osilesi²,

Adebawo³

et al. 2015

ABB

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“…This makes the toxicological assessment of the biological interactions between drugs, metabolites and the kidney of clinical importance and an essential yardstick for the safety of drugs [32]. Body and organ weight evaluations are an integral part of the toxicological assessment of chemical substances [33]. In the present study, juvenile albino rats administered with NVP did not show significant changes in body, absolute, relative kidney weights and serum electrolytes.…”

Section: Discussionmentioning

confidence: 47%

Nevirapine Alters Renal Function Parameters, Kidney Oxidative Stress Indices and Histology in Juvenile Albino Rats

Adikwu¹,

Bokolo²

2017

J Interdiscipl Histopathol

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Background: Nevirapine (NVP) is excreted by the kidney, therefore, use in human immunodeficiency virus exposed neonates could be of safety concern due to decreased renal function associated with the neonatal period. This study, therefore, investigated the nephrotoxic profile of NVP in juvenile albino rats. Materials and Methods: Juvenile albino rats used for this study were divided into seven groups A-G of five rats each. Rats in groups A and B were treated with water and normal saline as placebo and solvent control, respectively. Rats in groups C-G were treated orally with 4-32 mg/kg/day of NVP for 14 days, respectively including a recovery group. At the end of drug administration, rats were weighed and sacrificed. Blood was collected; serum extracted and evaluated for creatinine (Cr), urea (U), uric acid (UA), albumin (Ab), total protein (TP), and electrolytes (K + , Na + , Cl -and HCO 3 -). Kidneys were harvested, weighed and evaluated for superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), malondialdehyde (MDA) levels, and histological changes. Results: The body, absolute, relative kidney weights, and serum electrolytes were not significantly (P > 0.05) altered in the NVP treated rats in comparison to placebo control. However, serum levels of Ab and TP were decreased, whereas Cr, U, UA were increased significantly (P < 0.05) and in a dose-dependent manner in NVP-treated rats. Kidney levels of MDA were increased, whereas SOD, CAT, and GSH levels were decreased significantly (P < 0.05) and in a dose-dependent manner in NVP-treated rats. Kidneys of NVP-treated rats showed dose-dependent tubular necrosis. However, NVP-induced changes in all evaluated parameters were restored in the recovery group. Conclusion: This study observed dose-dependent and reversible renal toxicity in NVP treated juvenile albino rats. The use of NVP in neonates may be safe; however, neonatal renal function assessment is advice before and with NVP use.

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“…The organ to body weight ratio gives a proportional size of the organ to body weight. It has been suggested that the use of organ-body weight ratios may be valuable in evaluating the relationship between certain experimental situations and the biological response of a test organism [39]. The liver being the major organ carrying out metabolic and detoxification processes is unique among the body's vital organs in that it can be regenerated.…”

Section: Discussionmentioning

confidence: 99%

Selected Lipid Profile in the Serum & Tissues of Weaned Male Albino Rats Fed on Processed Atlantic Horse Mackerel (Trachurus trachurus)

Adeyemi¹,

Osilesi²,

Adebawo³

et al. 2015

ABB

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Trachurus trachurus (locally called kote) is a low cost table fish in south-west Nigeria. Study was conducted to determine the effect of processed kote on total triglycerides (TG) & cholesterol (Chol) in the serum as well as lactate dehydrogenase (LDH), creatinine (CRT), Chol and glucose (Gluc) in selected tissues of weaned male albino rats using standard methods. Chemical analyses were carried out on processed fillet; skin, head & bone (SHB) diets under standard conditions. 40 male rats were fed with processed fillet or SHB diets for 14 days to assay TG & Chol in serum as well as the activities of LDH & CRT in the heart, kidney, brain, spleen and small intestine; in addition to Chol and Gluc levels in the brain and liver. All data were subjected to analysis of variance by Duncan's multiple range test. Results indicated that levels of serum triglycerides and total cholesterol, as well as LDH and Gluc in the liver, heart, kidney and brain were reduced (p < 0.05) in rats fed on test diets compared to the controls, but within accepted limit. Levels of LDH and CRT in the kidney, stomach and small intestine were elevated (p < 0.05) compared to the controls, but within the accepted limit. Overall the coal smoked SHB was the best diet in terms of reduced levels of Chol & TG as well as healthy growth of the rats, followed by wood smoked diets. Thus, processed kote SHB could be a useful source of valuable nutrients in animal feed.

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Organ Weight: Body Weight Ratios in the Mongolian Gerbil, Meriones unguiculatus

Cited by 17 publications

References 6 publications

Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Activities in Selected Tissues of Rats Fed on Processed Atlantic Horse Mackerel (<i>Trachurus trachurus</i>)

Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Activities in Selected Tissues of Rats Fed on Processed Atlantic Horse Mackerel (<i>Trachurus trachurus</i>)

Nevirapine Alters Renal Function Parameters, Kidney Oxidative Stress Indices and Histology in Juvenile Albino Rats

Selected Lipid Profile in the Serum & Tissues of Weaned Male Albino Rats Fed on Processed Atlantic Horse Mackerel (<i>Trachurus trachurus</i>)

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Organ Weight: Body Weight Ratios in the Mongolian Gerbil, Meriones unguiculatus

Cited by 17 publications

References 6 publications

Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Activities in Selected Tissues of Rats Fed on Processed Atlantic Horse Mackerel (&lt;i&gt;Trachurus trachurus&lt;/i&gt;)

Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Activities in Selected Tissues of Rats Fed on Processed Atlantic Horse Mackerel (&lt;i&gt;Trachurus trachurus&lt;/i&gt;)

Nevirapine Alters Renal Function Parameters, Kidney Oxidative Stress Indices and Histology in Juvenile Albino Rats

Selected Lipid Profile in the Serum &amp; Tissues of Weaned Male Albino Rats Fed on Processed Atlantic Horse Mackerel (&lt;i&gt;Trachurus trachurus&lt;/i&gt;)

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Product

Resources

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Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Activities in Selected Tissues of Rats Fed on Processed Atlantic Horse Mackerel (<i>Trachurus trachurus</i>)

Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Activities in Selected Tissues of Rats Fed on Processed Atlantic Horse Mackerel (<i>Trachurus trachurus</i>)

Selected Lipid Profile in the Serum & Tissues of Weaned Male Albino Rats Fed on Processed Atlantic Horse Mackerel (<i>Trachurus trachurus</i>)