Organelle Stress and Metabolic Derangement in Kidney Disease

Inagi, Reiko

doi:10.3390/ijms23031723

Cited by 10 publications

(9 citation statements)

References 43 publications

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“…The change in energy metabolism is increasingly regarded as an important pathogenic mechanism in CKD, and normal energy metabolism is the basis for maintaining the physiology of the kidney ( 13 ). Although the kidney is not a metabolic organ, it requires a large amount of energy to filter waste, regulate electrolyte and fluid balance, and perform other processes ( 14 ).…”

Section: Metabolic Reprogramming In Renal Fibrosismentioning

confidence: 99%

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Molecular mechanisms underlying the role of hypoxia-inducible factor-1 α in metabolic reprogramming in renal fibrosis

et al. 2022

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Renal fibrosis is the result of renal tissue damage and repair response disorders. If fibrosis is not effectively blocked, it causes loss of renal function, leading to chronic renal failure. Metabolic reprogramming, which promotes cell proliferation by regulating cellular energy metabolism, is considered a unique tumor cell marker. The transition from oxidative phosphorylation to aerobic glycolysis is a major feature of renal fibrosis. Hypoxia-inducible factor-1 α (HIF-1α), a vital transcription factor, senses oxygen status, induces adaptive changes in cell metabolism, and plays an important role in renal fibrosis and glucose metabolism. This review focuses on the regulation of proteins related to aerobic glycolysis by HIF-1α and attempts to elucidate the possible regulatory mechanism underlying the effects of HIF-1α on glucose metabolism during renal fibrosis, aiming to provide new ideas for targeted metabolic pathway intervention in renal fibrosis.

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Section: Metabolic Reprogramming In Renal Fibrosismentioning

confidence: 99%

“…On the other hand, kidney damage alters energy metabolism. Thus, abnormal energy metabolism and renal fibrosis cause and affect each other, forming a vicious cycle ( 13 ).…”

Section: Metabolic Reprogramming In Renal Fibrosismentioning

confidence: 99%

Molecular mechanisms underlying the role of hypoxia-inducible factor-1 α in metabolic reprogramming in renal fibrosis

et al. 2022

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“…Due to their high prevalence and poor long-term clinical prognosis, they have become a major cause of morbidity and mortality and a serious public health problem worldwide. Globally, an estimated 850 million people experience some form of kidney disease, and it has become the 11th leading cause of death worldwide [ 1 ]. Despite tremendous efforts, the current state of treatment for kidney disease is not promising.…”

Section: Introductionmentioning

confidence: 99%

Renoprotective Effects of Tanshinone IIA: A Literature Review

et al. 2023

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The kidney is an important organ in the human body, with functions such as urine production, the excretion of metabolic waste, the regulation of water, electrolyte and acid–base balance and endocrine release. The morbidity and mortality of kidney diseases are increasing year by year worldwide, and they have become a serious public health problem. In recent years, natural products derived from fungi, plants and animals have become an important alternative source of treatment for kidney diseases because of their multiple pathways, multiple targets, safety, low toxicity and few side effects. Tanshinone IIA (Tan IIA) is a lipid-soluble diterpene quinone isolated from the Chinese herb Salvia miltiorrhiza, considered as a common drug for the treatment of cardiovascular diseases. As researchers around the world continue to explore its unknown biological activities, it has also been found to have a wide range of biological effects, such as anti-cancer, anti-oxidative stress, anti-inflammatory, anti-fibrotic, and hepatoprotective effects, among others. In recent years, many studies have elaborated on its renoprotective effects in various renal diseases, including diabetic nephropathy (DN), renal fibrosis (RF), uric acid nephropathy (UAN), renal cell carcinoma (RCC) and drug-induced kidney injury caused by cisplatin, vancomycin and acetaminophen (APAP). These effects imply that Tan IIA may be a promising drug to use against renal diseases. This article provides a comprehensive review of the pharmacological mechanisms of Tan IIA in the treatment of various renal diseases, and it provides some references for further research and clinical application of Tan IIA in renal diseases.

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“…Metabolic-Associated Kidney Diseases are a variety of kidney diseases caused by metabolic disorders, such as diabetic kidney disease (DKD), gouty nephropathy (GN), hypertensive kidney disease and obesity-related glomerular disease (ORG). High hemodynamic, excretory overload, endothelial dysfunction, chronic inflammation, and other mechanisms ( Dugan et al, 2013 ) act alone or in interaction to cause kidney injury ( Inagi, 2022 ) The prevention and treatment of such kidney diseases requires a multifactorial approach. Weight loss via diet control and exercise can reverse many pathophysiologic processes ( Mafra et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of natural products in the metabolic-associated kidney diseases via regulating mitochondrial dysfunction

et al. 2023

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Metabolic syndrome (MS) is a complex group of metabolic disorders syndrome with hypertension, hyperuricemia and disorders of glucose or lipid metabolism. As an important organ involved in metabolism, the kidney is inevitably attacked by various metabolic disorders, leading to abnormalities in kidney structure and function. Recently, an increasing number of studies have shown that mitochondrial dysfunction is actively involved in the development of metabolic-associated kidney diseases. Mitochondrial dysfunction can be used as a potential therapeutic strategy for the treatment of metabolic-associated kidney diseases. Many natural products have been widely used to improve the treatment of metabolic-associated kidney diseases by inhibiting mitochondrial dysfunction. In this paper, by searching several authoritative databases such as PubMed, Web of Science, Wiley Online Library, and Springer Link. We summarize the Natural Products Protect Against Metabolic-Associated Kidney Diseases by Regulating Mitochondrial Dysfunction. In this review, we sought to provide an overview of the mechanisms by which mitochondrial dysfunction impaired metabolic-associated kidney diseases, with particular attention to the role of mitochondrial dysfunction in diabetic nephropathy, gouty nephropathy, hypertensive kidney disease, and obesity-related nephropathy, and then the protective role of natural products in the kidney through inhibition of mitochondrial disorders, thus providing a systematic understanding of the targets of mitochondrial dysfunction in metabolic-associated kidney diseases, and finally a review of promising therapeutic targets and herbal candidates for metabolic-associated kidney diseases through inhibition of mitochondrial dysfunction.

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Organelle Stress and Metabolic Derangement in Kidney Disease

Cited by 10 publications

References 43 publications

Molecular mechanisms underlying the role of hypoxia-inducible factor-1 α in metabolic reprogramming in renal fibrosis

Molecular mechanisms underlying the role of hypoxia-inducible factor-1 α in metabolic reprogramming in renal fibrosis

Renoprotective Effects of Tanshinone IIA: A Literature Review

Protective effect of natural products in the metabolic-associated kidney diseases via regulating mitochondrial dysfunction

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