Renoprotective Effects of Tanshinone IIA: A Literature Review

Abstract

The kidney is an important organ in the human body, with functions such as urine production, the excretion of metabolic waste, the regulation of water, electrolyte and acid–base balance and endocrine release. The morbidity and mortality of kidney diseases are increasing year by year worldwide, and they have become a serious public health problem. In recent years, natural products derived from fungi, plants and animals have become an important alternative source of treatment for kidney diseases because of their multiple pathways, multiple targets, safety, low toxicity and few side effects. Tanshinone IIA (Tan IIA) is a lipid-soluble diterpene quinone isolated from the Chinese herb Salvia miltiorrhiza, considered as a common drug for the treatment of cardiovascular diseases. As researchers around the world continue to explore its unknown biological activities, it has also been found to have a wide range of biological effects, such as anti-cancer, anti-oxidative stress, anti-inflammatory, anti-fibrotic, and hepatoprotective effects, among others. In recent years, many studies have elaborated on its renoprotective effects in various renal diseases, including diabetic nephropathy (DN), renal fibrosis (RF), uric acid nephropathy (UAN), renal cell carcinoma (RCC) and drug-induced kidney injury caused by cisplatin, vancomycin and acetaminophen (APAP). These effects imply that Tan IIA may be a promising drug to use against renal diseases. This article provides a comprehensive review of the pharmacological mechanisms of Tan IIA in the treatment of various renal diseases, and it provides some references for further research and clinical application of Tan IIA in renal diseases.

Research progress on the role of the Wnt signaling pathway in pituitary adenoma

“…Natural plant products have become an essential source of new anticancer drugs due to their multiple modes of action, multiple targets, safety, low toxicity, and few side effects ( 87 ). In 2017, Li et al.…”

“…targets, safety, low toxicity, and few side effects (87). In 2017, Li et al found that the CAG of Yunshi can induce apoptosis in cells of PAs by inhibiting the Wnt pathway.…”

Tanshinone IIA suppresses ferroptosis to attenuate renal podocyte injury in diabetic nephropathy through the embryonic lethal abnormal visual‐like protein 1 and acyl‐coenzyme A synthetase long‐chain family member 4 signaling pathway

“…As a diterpene quinone phytochemical derived from Chinese medicine, Salvia miltiorrhiza , tanshinone IIA (TIIA) has been used to treat cardiovascular and inflammatory diseases for >2,000 years in China 8 . Furthermore, numerous studies have verified that TIIA possesses diverse powerful pharmacological properties, including anti‐atherosclerotic, anti‐oxidant, anti‐inflammatory and hepatoprotective effects 9 , 10 , 11 . In fact, TIIA has been reported as a protective function against streptozotocin‐induced renal dysfunction and morphologic pathology in DN rats through repressing protein kinase RNA (PKR)‐like ER kinase (PERE) pathway activation 12 .…”

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

“…These activities are likely related to the presence of quinone diterpenes, also known as tanshinones, including tanshinone I, tanshinone IIA, dihydrotanshinone I, cryptotanshinone, and hydroxytanshinone. Among these, the most interesting is tanshinone IIA, which demonstrated cardiovascular-protective [29,30] and renoprotective [31] activities, and antiviral activity [32]. It has also been recently investigated as a natural anticancer compound, due to its inhibitory effect on cancer with a certain regulatory effect on tumor angiogenesis [33][34][35].…”