Organic Acid Production by the Yeast Yarrowia lipolytica: A Review of Prospects

Abstract

The review sums up the results of studies of (1) physiological growth characteristics of the yeast Yarrowia lipolytica cultured in the presence of diverse carbon sources ( n -alkanes, glucose, and glycerol) and(2) superhigh synthesis of organic acids, which was performed at the Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences. Microbiological processes of obtaining α -ketoglutaric, pyruvic, isocitric, and citric acids are discussed. In memoriam Aleksandr Borisovich Lozinov

Microbial Conversion of Waste Glycerol from Biodiesel Production into Value-Added Products

“…Citric acid is a flavoring additive and preservative agent in the food industry with a current estimated annual production of more than 800,000 tons which is expected to continue to increase by 5% per year [111][112][113]. Citric acid production from the submerged fermentation of Aspergillus niger (fungus) using sugar as substrate is a well-developed technique.…”

Citric Acid Production by Yarrowia lipolytica Yeast on Different Renewable Raw Materials

“…Over the past 40 years, the interest of researchers has focused on yeast as a producer of CA; the yeast Yarrowia lipolytica has been the most used CA producer [1][2][3]. Initially, this kind of yeast attracted the attention of researchers due to its ability to grow and synthesize CA in media with n alkanes-an available and cheap substrate [2].…”

“…CA production by fungi is a complicated and environmentally unsafe process; as a result of its implementation, a large number of both liquid effluents containing mineral acids, ballast organic substances, cyanides, and solid wastes, primarily gypsum, are accumulated. Moreover, A. niger is an opportunistic pathogenic fungi and can cause allergic diseases and aspergillosis [2,3].…”

Industrial derivative of tallow: a promising renewable substrate for microbial lipid, single-cell protein and lipase production by Yarrowia lipolytica

“…The non-conventional dimorphic yeast Yarrowia (CandidaSaccharomycopsis) lipolytica has been efficiently cultivated on various hydrophobic substances producing many extra-or intra-cellular metabolites of industrial significance (Fickers et al 2005a;Finogenova et al 2005). Traditionally, the most widespread biotechnological application of strains belonging to this species has focused on the production of single-cell protein (microbial biomass) (Barth and Gaillardin, 1996;Musiał et al 2004).…”