Organic Colouring Agents in the Pharmaceutical Industry

Šuleková, Monika; Smrčová, Miroslava; Hudák, Alexander; Heželová, Mária; Федорова, М. А.

doi:10.1515/fv-2017-0025

Cited by 39 publications

(17 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dalam formulasi sediaan farmasi, zat warna makanan banyak digunakan. Tujuan penambahan zat warna adalah untuk membedakan antara obat-obatan yang dikonsumsi serta mengurangi kesalahan dalam penggunaan obat (Sulekova et al, 2017).…”

Section: Pendahuluanunclassified

Physicochemical Study of Mangosteen (Garcinia mangostana L.) peel Extract as Coloring Agent in Tablet Formulation

Asra¹,

Rusdi²,

Nofrianti³

2020

JPS

View full text Add to dashboard Cite

The mangosteen peel (Garcinia mangostana L.) contains anthocyanin pigments, which has an important role in coloring. This study aims to determine the physicochemical properties of mangosteen peel extract (Garcinia mangostana L.) with two methods, which is an examination with UV-Vis and FTIR spectrophotometry. Then the extract was characterized, identified, and analyzed for its stability against temperature, pH, and applied as a coloring agent in the formulation of pharmaceutical preparations (tablets). The results showed that the yield of mangosteen peel extract obtained 13.0975 %, drying losses 5.2822 %, total ash content 14.488 %, acid insoluble ash content 0.684 %, water-soluble extract content 29.58 %, extract content dissolved in ethanol 37.78 %, total anthocyanin content with λmax = 367 nm which is = 9.58 mg / 100 g and with λmax = 289 nm which is = 52.43 mg / 100 g. In this study, the anthocyanin pigment content in mangosteen peel extract cannot be used as an alternative to natural dyes for pharmaceutical preparations (tablets).

show abstract

Section: Pendahuluanunclassified

Physicochemical Study of Mangosteen (Garcinia mangostana L.) peel Extract as Coloring Agent in Tablet Formulation

Asra¹,

Rusdi²,

Nofrianti³

2020

JPS

View full text Add to dashboard Cite

show abstract

“…Various kinds of colorful dyes have immensely enriched our lives as we image [1][2]. Yet, more and more residual dyes are directly discharged into the environment during the manufacturing and operation process [3], which are causing several adverse effects on the living system and even threatening human health [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Growth and Removal Behavior of Magnesium Oxide Microspheres towards Methyl Orange and Methylene Blue in Aqueous Solution

Ahmed¹,

Pan²,

Li³

et al. 2020

Preprint

View full text Add to dashboard Cite

The adsorption of dyes from the industrial influent has attracted great interest to overcome water pollution. In this work, we carefully investigated the growth process of hierarchical MgO microspheres and the difference in the corresponding removal behavior towards two dyes: anionic methyl orange and cationic methylene blue. The MgO microspheres were formed by the self-assembly of thin nanosheets following the reaction time and exhibited the maximum removal capacities are 940.14 mg g-1 for methyl orange and 354.00 mg g-1 for methylene blue. The anionic methyl orange and cationic methylene blue adsorption follow the pseudo-second-order kinetic model, Freundlich isothermal model. The difference in the removal behavior towards two dyes is strongly related to the surface charge of MgO and the charge of pollutants. This work will benefit design and improvement in the removal performance of novel porous adsorbents.

show abstract

“…[2] Carmoisine is a Food and Drug Administration (FDA) approved synthetic azo dye used as a colorant in many drugs and has been reported in the literature for causing rare allergic skin reactions in vulnerable individuals, even at acceptable doses. [3] Children are getting attracted by the increased esthetic appearance of pharmaceutical products as a result of the use of dyes to increase their medication adherence. [3] However, this carmoisine is an organic substance that may have the potential to interact with the human body and can rarely cause adverse effects such as skin reactions, respiratory reactions, and hyperactivity in children.…”

Section: Introductionmentioning

confidence: 99%

“…[3] Children are getting attracted by the increased esthetic appearance of pharmaceutical products as a result of the use of dyes to increase their medication adherence. [3] However, this carmoisine is an organic substance that may have the potential to interact with the human body and can rarely cause adverse effects such as skin reactions, respiratory reactions, and hyperactivity in children. [3] This case report adds an increased awareness of the probability of allergic skin reaction to carmoisine in a previously sensitized person.…”

Section: Introductionmentioning

confidence: 99%

A pediatric case report of fixed drug eruption related to carmoisine colorant present in paracetamol syrup

et al. 2019

View full text Add to dashboard Cite

Various adverse drug reactions, including hypersensitivity skin reaction after the exposure to carmoisine colorant, have already been reported in the literature. This case report gives the details of a 5-year-old male child with a recurrent fixed drug eruption (FDE) over the neck and trunk after the use of paracetamol syrup containing carmoisine as a colorant. Patch test to the carmoisine colorant in the paracetamol syrup was positive. This case report adds an increased awareness of the probability of allergic skin reaction to carmoisine in a previously sensitized person. The report also emphasizes the necessity to consider artificial dyes in pharmaceutical products as a potential cause for FDE.

show abstract

Organic Colouring Agents in the Pharmaceutical Industry

Abstract: ABSTRACT

Cited by 39 publications

References 47 publications

Physicochemical Study of Mangosteen (Garcinia mangostana L.) peel Extract as Coloring Agent in Tablet Formulation

Physicochemical Study of Mangosteen (Garcinia mangostana L.) peel Extract as Coloring Agent in Tablet Formulation

Growth and Removal Behavior of Magnesium Oxide Microspheres towards Methyl Orange and Methylene Blue in Aqueous Solution

A pediatric case report of fixed drug eruption related to carmoisine colorant present in paracetamol syrup

Contact Info

Product

Resources

About