Organic Phosphorus-Selenium Chemistry

Hua, Guoxiong; Woollins, J. Derek

doi:10.1007/978-3-642-20699-3_1

Cited by 6 publications

(8 citation statements)

References 95 publications

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“…Selenium is an element discovered by Berzelius in 1817. It is a rare, but widespread, element with an abundance of 0.05–0.09 parts per million [ 65 ]. It is similar to phosphorus in chemical properties.…”

Section: Selenium and Curcumin: General Introduction And Protectivmentioning

confidence: 99%

Protective and Detoxifying Effects Conferred by Dietary Selenium and Curcumin against AFB1-Mediated Toxicity in Livestock: A Review

Limaye

Chou

et al. 2018

Toxins

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Aflatoxin B1 (AFB1), among other aflatoxins of the aflatoxin family, is the most carcinogenic and hazardous mycotoxin to animals and human beings with very high potency leading to aflatoxicosis. Selenium is an essential trace mineral possessing powerful antioxidant functions. Selenium is widely reported as an effective antioxidant against aflatoxicosis. By preventing oxidative liver damage, suppressing pro-apoptotic proteins and improving immune status in AFB1 affected animals; selenium confers specific protection against AFB1 toxicity. Meticulous supplementation of animal feed by elemental selenium in the organic and inorganic forms has proven to be effective to ameliorate AFB1 toxicity. Curcumin is another dietary agent of importance in tackling aflatoxicosis. Curcumin is one of the major active ingredients in the tubers of a spice Curcuma longa L., a widely reported antioxidant, anticarcinogenic agent with reported protective potential against aflatoxin-mediated liver damage. Curcumin restricts the aflatoxigenic potential of Aspergillus flavus. Curcumin inhibits cytochrome P450 isoenzymes, particularly CYP2A6 isoform; thereby reducing the formation of AFB1-8, 9-epoxide and other toxic metabolites causing aflatoxicosis. In this review, we have briefly reviewed important aflatoxicosis symptoms among animals. With the main focus on curcumin and selenium, we have reviewed their underlying protective mechanisms in different animals along with their extraction and production methods for feed applications.Keywords: aflatoxin B1; anti-AFB1 dietary supplement; curcumin; selenium; antioxidant status Key contribution: We have reviewed protective roles of selenium and curcumin in specific relation to tacking AFB1 toxicity in the livestock along with their reported underlying mechanisms for the potential feed applications catering across a broad host range.

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Section: Selenium and Curcumin: General Introduction And Protectivmentioning

confidence: 99%

Protective and Detoxifying Effects Conferred by Dietary Selenium and Curcumin against AFB1-Mediated Toxicity in Livestock: A Review

Limaye

Chou

et al. 2018

Toxins

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“…[1][2][3][4][5][6] In part, this tardiness can be attributed to the thermal and photochemical lability of phosphorus-tellurium bonds that makes many of these compounds difficult to manipulate. Significantly, there is no tellurium counterpart of the Lawesson's or Woollins' reagents, which contain both bridging (P-E) and terminal P=E (E = S, Se, respectively) functionalities; the latter reagents find wide applications in organic chemistry for the NMR studies of phosphorus-tellurium compounds and, in particular, the magnitude of the one-bond coupling constant 1 J( 31 P, 125 Te) are of considerable interest.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

“…5,6 In addition, organophosphoruschalcogen compounds are used as pesticides or nerve agents, as precursors for metal chalcogenide thin films or nanoparticles, in metal extraction processes and as lubricant additives. The chemistry of phosphorus-chalcogen compounds has been covered comprehensively in a recent book chapter that deals primarily with sulfur and selenium-containing systems.…”

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confidence: 99%

Organophosphorus–Tellurium Chemistry: From Fundamentals to Applications

2015

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“…However, Rothenberger has developed direct reactions of WR with metal salts to good effect 49 and we have carried out some studies relating to our earlier work on ZDDP. 50 We have reviewed the reactivity of WR, previously 51,52 and the following provides a brief summary of this together with more recent results.…”

Section: Scheme 18 Synthesis Of Organophosphorus-selenium Heterocycles From Organocyclophosphinesmentioning

confidence: 99%

How Not to Discover a New Reagent. The Evolution and Chemistry of Woollins' Reagent

Woollins¹

2012

Synlett

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Organic Phosphorus-Selenium Chemistry

Cited by 6 publications

References 95 publications

Protective and Detoxifying Effects Conferred by Dietary Selenium and Curcumin against AFB1-Mediated Toxicity in Livestock: A Review

Protective and Detoxifying Effects Conferred by Dietary Selenium and Curcumin against AFB1-Mediated Toxicity in Livestock: A Review

Organophosphorus–Tellurium Chemistry: From Fundamentals to Applications

How Not to Discover a New Reagent. The Evolution and Chemistry of Woollins' Reagent

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