Organic Polymeric Nanomaterials as Advanced Tools in the Fight Against Antibiotic-Resistant Infections

Balaure, Paul Cătălin; Gudovan, Dragoş; Gudovan, Iulia Alexandra

doi:10.1016/b978-0-323-41625-2.00006-5

Cited by 3 publications

(3 citation statements)

References 256 publications

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“…Moreover, smart nano-transporters can be engineered to trigger drug release in response to small microenvironmental changes in local pH, temperature, redox potential, and enzyme activity, as well as to remote, externally applied stimuli such as electric fields, laser pulses, ultrasounds, and magnetic fields [3][4][5]. Furthermore, nanovehicles can overcome MDR mechanisms, including decreased uptake and increased efflux of tumor cell drugs [6].…”

Section: Introductionmentioning

confidence: 99%

Anti-Cancer Nanopowders and MAPLE-Fabricated Thin Films Based on SPIONs Surface Modified with Paclitaxel Loaded β-Cyclodextrin

et al. 2021

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Globally, cancer is the second most common cause of death, and Europe accounts for almost 25% of the global cancer burden, although its people make up only 10% of the world’s population. Conventional systemically administered anti-cancer drugs come with important drawbacks such as inefficiency due to poor bioavailability and improper biodistribution, severe side effects associated with low therapeutic indices, and the development of multidrug resistance. Therefore, smart nano-engineered targeted drug-delivery systems with tailored pharmacokinetics and biodistribution which can selectively deliver anti-cancer agents directly to the tumor site are the solution to most difficulties encountered with conventional therapeutic tools. Here, we report on the synthesis, physicochemical characterization, and in vitro evaluation of biocompatibility and anti-tumor activity of novel magnetically targetable SPIONs based on magnetite (Fe3O4) nanoparticles’ surface modified with β-cyclodextrin (CD) and paclitaxel (PTX)–guest–host inclusion complexes (Fe3O4@β-CD/PTX). Both pristine Fe3O4@β-CD nanopowders and PTX-loaded thin films fabricated by MAPLE technique were investigated. Pristine Fe3O4@β-CD and Fe3O4@β-CD/PTX thin films were physicochemically characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), thermal analysis, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The biocompatibility of bare magnetic nanocomposite thin films was evaluated by MTT cell viability assay on a normal 3T3 osteoblast cell line culture and by measuring the level of NO in the culture medium. No significant modifications, neither in cell viability nor in NO level, could be observed, thereby demonstrating the excellent biocompatibility of the SPIONs thin films. Inverted phase-contrast microscopy showed no evident adverse effect on the morphology of normal osteoblasts. On the other hand, Fe3O4@β-CD/PTX films decreased the cell viability of the MG-63 osteosarcoma cell line by 85%, demonstrating excellent anti-tumor activity. The obtained results recommend these magnetic hybrid films as promising candidates for future delivery, and hyperthermia applications in cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Anti-Cancer Nanopowders and MAPLE-Fabricated Thin Films Based on SPIONs Surface Modified with Paclitaxel Loaded β-Cyclodextrin

et al. 2021

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“…We also demonstrate that by tailoring the topography in the micro and nanoscale, as well as the surface chemistry and by enriching the surface with an effective antibacterial agent, a passive antibacterial surface can be realized on every substrate avoiding analogous concepts for surfaces with dual functionality (15), which require either complex synthesis methods or energy consumption. 8,24 We present such surfaces, which we term as "hybrid" (i.e., antiadhesive surface and bactericidal agent) and as we will show, these surfaces induce both short-term and long-term, passive, antibacterial action.…”

Section: Introductionmentioning

confidence: 99%

Is There a Threshold in the Antibacterial Action of Superhydrophobic Surfaces?

Ellinas

Kefallinou

Stamatakis

et al. 2017

ACS Appl. Mater. Interfaces

110

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The realization of antibacterial surfaces is an important scientific problem, which may be addressed by the use of superhydrophobic surfaces, reducing bacterial adhesion. However, there are several limitations and contradicting reports on the antibacterial efficacy of such surfaces. Moreover, achieving antibacterial action through minimization of adhesion does not ensure complete protection against bacteria. Here, we identify the important factors affecting antibacterial action on superhydrophobic surfaces, emphasizing the role of bacterial concentration, and observing an upper concentration threshold above which antibacterial action of any surface is compromised. Finally, we propose metal enriched, superhydrophobic surfaces, as the "ultimate" "hybrid" antibacterial surfaces for in vitro applications.

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“…Antibiotic‐resistant bacterial strains have become a significant public health concern across the world. Each year, several million people become infected with antibiotic‐resistant bacteria, with at least 25,000 people dying directly from these illnesses (Balaure et al., 2017). Staphylococcus aureus is a common human pathogen that causes various infections in the community and hospitals, including infective endocarditis, bloodstream, bone, skin, and soft tissue infections (Abd El‐Baky et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

Fabrication and antimicrobial properties of novel meropenem‐honey encapsulated chitosan nanoparticles against multiresistant and biofilm‐forming Staphylococcus aureus as a new antimicrobial agent

Hajimohammadi,

Momtaz,

Tajbakhsh

2024

Veterinary Medicine & Sci

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BackgroundHoney exhibits a broad spectrum of antibacterial activity against Gram‐positive and Gram‐negative bacteria, including methicillin‐resistant Staphylococcus aureus (MRSA) ones. Chitosan (Cs) is a mucoadhesive polymer that also has antibacterial properties. Special attention has been paid to the design of polymeric nanoparticles (NPs) as new nano drug delivery systems to overcome bacterial resistance and its problems.ObjectivesThe aim of the present study is to synthesize Cs‐meropenem NPs with/without honey as an antibiofilm and antibacterial agent to inhibit Staphylococcus aureus.MethodsThis study synthesized meropenem and honey‐loaded Cs nanogels and subsequently characterized them by Field Emission Scanning Electron Microscopy (FESEM), Fourier Transform Infrared Spectroscopy (FTIR), and DLS‐zeta potential. Using the broth microdilution and crystal violet assays, the antibacterial and antibiofilm activity of meropenem and honey‐loaded Cs nanogel, free meropenem, free honey, and free Cs NPs were investigated in vitro against MRSA strains. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) was also used to test the cytotoxicity of several Cs‐NPs compound against the HEK‐293 regular cell line.ResultsThe average size of meropenem and honey‐Cs‐NPs was reported to be 119.885 nm, and encapsulation efficiency was 88.33 ± 0.97 with stability up to 60 days at 4°C. The NPs showed enhanced antibiofilm efficacy against S. aureus at sub‐minimum inhibitory concentrations. Additionally, the cytotoxicity of meropenem and honey‐encapsulated Cs against the HEK‐293 normal cell line was insignificant.ConclusionsOur findings suggested that meropenem and honey‐Cs‐NPs might be potential antibacterial and antibiofilm materials.

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Organic Polymeric Nanomaterials as Advanced Tools in the Fight Against Antibiotic-Resistant Infections

Cited by 3 publications

References 256 publications

Anti-Cancer Nanopowders and MAPLE-Fabricated Thin Films Based on SPIONs Surface Modified with Paclitaxel Loaded β-Cyclodextrin

Anti-Cancer Nanopowders and MAPLE-Fabricated Thin Films Based on SPIONs Surface Modified with Paclitaxel Loaded β-Cyclodextrin

Is There a Threshold in the Antibacterial Action of Superhydrophobic Surfaces?

Fabrication and antimicrobial properties of novel meropenem‐honey encapsulated chitosan nanoparticles against multiresistant and biofilm‐forming Staphylococcus aureus as a new antimicrobial agent

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