Organically modified clay supported chitosan/hydroxyapatite-zinc oxide nanocomposites with enhanced mechanical and biological properties for the application in bone tissue engineering

Bhowmick, Arundhati; Banerjee, Shib Shankar; Pramanik, Nilkamal; Jana, Piyali; Mitra, Tapas; Gnanamani, A.; Das, Manas; Kundu, Patit Paban

doi:10.1016/j.ijbiomac.2017.07.168

Cited by 66 publications

(22 citation statements)

References 37 publications

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“…The most common co-modified material is hydroxyapatite (HA). [93][94][95] Maimaiti et al 26 produced coatings of nano-HA (nHA) and ZnO-NPs and employed polypyrrole as a dual regulator using the pulse electrochemical deposition method. This coating exhibited good antibacterial properties while retaining mineralization functionality.…”

Section: Antibacterial Properties Of Zno-nps Antibacterial Mechanism mentioning

confidence: 99%

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

Li¹,

Yang²,

Qing³

et al. 2020

IJN

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Prosthesis-associated infections and aseptic loosening are major causes of implant failure. There is an urgent need to improve the antibacterial ability and osseointegration of orthopedic implants. Zinc oxide nanoparticles (ZnO-NPs) are a common type of zinccontaining metal oxide nanoparticles that have been widely studied in many fields, such as food packaging, pollution treatment, and biomedicine. The ZnO-NPs have low toxicity and good biological functions, as well as antibacterial, anticancer, and osteogenic capabilities. Furthermore, ZnO-NPs can be easily obtained through various methods. Among them, green preparation methods can improve the bioactivity of ZnO-NPs and strengthen their potential application in the biological field. This review discusses the antibacterial abilities of ZnO-NPs, including mechanisms and influencing factors. The toxicity and shortcomings of anticancer applications are summarized. Furthermore, osteogenic mechanisms and synergy with other materials are introduced. Green preparation methods are also briefly reviewed.

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Section: Antibacterial Properties Of Zno-nps Antibacterial Mechanism mentioning

confidence: 99%

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

Li¹,

Yang²,

Qing³

et al. 2020

IJN

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“…Regarding the specific use of ZnO nanomaterials for bone tissue engineering, ZnO was proposed as a suitable filler in composite matrices based on hydroxyapatite,17,18 graphene oxide,19 polymers,20,21 or as a coating for orthopaedic and dental implants, promoting antibacterial response together with osteoblast growth, adhesion and their metabolic activity 22. Colon et al 23 have analysed the effects of ZnO micro- and nano-powders, pressed into compacts, on osteoblast functions and S. epidermidis adhesion.…”

Section: Introductionmentioning

confidence: 99%

Zinc oxide nanocrystals as a nanoantibiotic and osteoinductive agent

et al. 2019

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In this paper we aim to analyse the behaviour of ZnO nanocrystals (ZnO NCs), prepared with a new synthetic approach and not embedded in any composite matrix, for bone implant applications in vitro. In particular, we have developed a novel, fast and reproducible microwave-assisted synthesis, to obtain highly-crystalline, round-shaped ZnO NCs of 20 nm in diameter as an extremely-stable colloidal solution in ethanol. The nanocrystals were also partially chemically functionalized by anchoring amino-propyl groups to the ZnO surface (ZnO–NH2 NCs). Thus, the role of both ZnO NC concentration and surface chemistry were tested in terms of biocompatibility towards pre-osteoblast cells, promotion of cell proliferation and differentiation, and also in terms of antimicrobial activity against Gram positive and negative bacteria, such as Escherichia coli and Staphylococcus aureus, respectively. The results suggest that ZnO–NH2 NCs is the most promising candidate to solve infectious disease in bone implants and at the same time promote bone tissue proliferation, even at high concentrations. Although further investigations are needed to clarify the mechanism underlying the inhibition of biofilm formation and to investigate the role of the ZnO–NH2 NCs in in vivo assays, we demonstrated that fine and reproducible control over the chemical and structural parameters in ZnO nanomaterials can open up new horizons in the use of functionalized ZnO NCs as a highly biocompatible and osteoinductive nanoantibiotic agent for bone tissue engineering.

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“…Due to its bioactivity and biodegradability Ch is popular among pharmaceutical, medical and cosmetic concerns. It is used primarily as a support for the supply of drugs and proteins (Moradi et al 2019), biosensors (Zhang et al 2018), nanofibers (scaffolds in tissue engineering) (Rijal et al 2018;Bhowmick et al 2018). In the area of life science, titanium dioxide (TiO 2 ) is also often found, which is generally associated with its role as natural, physical UV filter or drug filler.…”

Section: Introductionmentioning

confidence: 99%

Langmuir monolayer study of phospholipid DPPC on the titanium dioxide–chitosan–hyaluronic acid subphases

2019

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The studies of model biological membranes consisted of phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were carried out by means of the Langmuir monolayer technique using subphases containing chitosan (Ch), titanium (IV) oxide (TiO 2 ), hyaluronic acid (HA) or mixture of them. The aim was to determine the effect of individual components of subphase and their respective combinations on behavior of the DPPC membrane. The systems were tested at room temperature (20 °C) and at a natural pH of about 4.8, which was close to the pH of the human skin (4.7-5.6). The surface pressure-area per molecule (π-A) isotherms were obtained. Their analysis showed that all substances studied affected the phospholipid membrane which was revealed in the changes of mean molecular area, compression modulus and pressure of the liquidexpanded/liquid-condensed (LE/LC) phase transition. The results were discussed in terms of the nature and strength of mutual interactions. The more profound effect was found at low surface pressures at which the monolayers occurred in more expanded state. However, at the surface pressure corresponding to that of biological membranes, systems had very similar parameters compared to model DPPC isotherm.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Organically modified clay supported chitosan/hydroxyapatite-zinc oxide nanocomposites with enhanced mechanical and biological properties for the application in bone tissue engineering

Cited by 66 publications

References 37 publications

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

Zinc oxide nanocrystals as a nanoantibiotic and osteoinductive agent

Langmuir monolayer study of phospholipid DPPC on the titanium dioxide–chitosan–hyaluronic acid subphases

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