Organization of subtelomeric repeats in Plasmodium berghei.

Dore, E.; Pace, Tomasino; Ponzi, Marta; Picci, Leonardo; Frontali, C.

doi:10.1128/mcb.10.5.2423

Cited by 45 publications

(20 citation statements)

References 31 publications

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“…The numbers of TA repeats in a telomere are highly variable (14), a property shared with similar DNA in other organisms; in several cases this is attributed to recombination between chromosome ends (15,18,20,(28)(29)(30).…”

Section: Methodsmentioning

confidence: 99%

“…

A family of 340-bp tandem telomere-associated DNA repeats is present in 50-to 200-kb (18,30,48). Thus, there is no absolute topological distinction between the two types of DNA.

…”

mentioning

confidence: 99%

“…Furthermore, what is normally subtelomeric DNA can in certain yeast mutants become terminal and permit survival and growth (31). Telomeric DNA, on the other hand, may occupy subterminal positions (18,30,48). Thus, there is no absolute topological distinction between the two types of DNA.…”

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confidence: 99%

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A family of complex tandem DNA repeats in the telomeres of Chironomus pallidivittatus.

Yj¹,

Kamnert²,

López³

et al. 1994

Mol. Cell. Biol.

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A family of 340-bp tandem telomere-associated DNA repeats is present in 50-to 200-kb (18,30,48). Thus, there is no absolute topological distinction between the two types of DNA. One telomeric function, for which telomerase is responsible, is to restore DNA that is lost after replications (22,23). Another is the maintenance of chromosomal integrity (see reference 2 and references therein) believed to be related to the propensity of telomeric DNA to form secondary structures (see reference 6 and references therein). Obviously, telomere-associated DNA, when in a terminal position, also has to fulfil these functions. Processes like unequal crossing over (34), gene conversion (39), and transposition (1,3,4,16,26,45,46) can be invoked to explain DNA additions. Little is known, however, about how telomereassociated DNA could maintain chromosomal integrity and about its subtelomeric roles.Chromosome ends in the dipteran insect Chironomus pallidivittatus have a potential value in the study of telomereassociated DNA, because of the schematic structure of their long tandem arrays of complex 340-bp repeat units (TA re-* Corresponding author. Mailing address:

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Section: Methodsmentioning

confidence: 99%

“…

A family of 340-bp tandem telomere-associated DNA repeats is present in 50-to 200-kb (18,30,48). Thus, there is no absolute topological distinction between the two types of DNA.

…”

mentioning

confidence: 99%

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A family of complex tandem DNA repeats in the telomeres of Chironomus pallidivittatus.

Yj¹,

Kamnert²,

López³

et al. 1994

Mol. Cell. Biol.

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“…The insertion appears to split one of the original telomeres, leaving an internal telomeric sequence (about 1 kb in length). This is exactly the effect predicted for a recombinational event involving one of the short (160-bp) internal telomeric sequences, periodically positioned in the P. berghei subtelomeric repeat structure (4), and the actual telomere of a nonhomologous chromosome. Since a reciprocal change of -50 kb would be undetectable in one of the larger chromosomes, we cannot distinguish between reciprocal and nonreciprocal recombinational mechanisms of sequence transfer, such as unequal crossing over or strand invasion and copy (5).…”

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confidence: 48%

“…These repeats appear to be clustered exclusively in a subtelomeric position on several chromosomes (4,8). The 2.3-kb unit contains a short stretch (160 bp) of a telomere-related sequence (8), including some perfect tandem repeats of the 27-bp motif CCCTGAA CCATAAA CCTGAA CCCTAAA, composed of two canonical (CCCTGAA, CCCTAAA) and two modified (CCAT AAA, CCTGAA) heptanucleotides typical of plasmodial telomeres (11).…”

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confidence: 99%

Long insertions within telomeres contribute to chromosome size polymorphism in Plasmodium berghei.

Pace¹,

Ponzi²,

Dore³

et al. 1990

Mol. Cell. Biol.

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During prolonged in vivo mitotic multiplication of a Plasmodium berghei ANKA clone (8417HP), parasites that contained an enlarged version of chromosome 4 were observed. Restriction mapping and hybridization results demonstrated that the extra DNA present in the enlarged chromosome consists of 2.3-kb tandem repeats, known to be normally located in subtelomeric position at several chromosomal ends but absent in the original chromosome. The inserted 2.3-kb units appeared to interrupt one of the original telomeres and to create an internal (approximately 1-kb-long) telomeric sequence.

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Louis¹

2013

Subtelomeres

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Organization of subtelomeric repeats in Plasmodium berghei.

Cited by 45 publications

References 31 publications

A family of complex tandem DNA repeats in the telomeres of Chironomus pallidivittatus.

A family of complex tandem DNA repeats in the telomeres of Chironomus pallidivittatus.

Long insertions within telomeres contribute to chromosome size polymorphism in Plasmodium berghei.

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