Organizational challenges in clinical genomic research

Altshuler, Jill S.; Altshuler, David

doi:10.1038/nature02629

Cited by 13 publications

(6 citation statements)

References 4 publications

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“…The challenge now is for clinical scientists to provide wellcharacterized populations with carefully recorded phenotypic and environmental data. This challenge will extend to the acquisition of new organizational skills to collate these data from many centers and provide integration with the large volume of genetic data soon to be generated (89). The opportunities are great for future diabetes genetic epidemiology research to provide clinically useful information, the most vital goal of the Human Genome Project.…”

Section: Unanswered Questions and Future Opportunitiesmentioning

confidence: 99%

Genetic epidemiology of diabetes

Permutt

Wasson²,

Cox³

2005

Journal of Clinical Investigation

236

146

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Conventional genetic analysis focuses on the genes that account for specific phenotypes, while traditional epidemiology is more concerned with the environmental causes and risk factors related to traits. Genetic epidemiology is an alliance of the 2 fields that focuses on both genetics, including allelic variants in different populations, and environment, in order to explain exactly how genes convey effects in different environmental contexts and to arrive at a more complete comprehension of the etiology of complex traits. In this review, we discuss the epidemiology of diabetes and the current understanding of the genetic bases of obesity and diabetes and provide suggestions for accelerated accumulation of clinically useful genetic information.

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Section: Unanswered Questions and Future Opportunitiesmentioning

confidence: 99%

Genetic epidemiology of diabetes

Permutt

Wasson²,

Cox³

2005

Journal of Clinical Investigation

236

146

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“…Deviation of the g-factor from 2.0 (g-factor of free electron, see also [6]) points on the magnification of hybridization of the europium f-electron states with the p-s-states of the band electrons. Since ground state of Eu 2+ ion is pure spin state 8 S 7/2 , the resultant orbital angular momentum equal to zero.…”

Section: Resonance Fields Linewidth G-factormentioning

confidence: 99%

Spin and Valence Fluctuation in Eu Compounds with CaAl₂Si₂-Structure

Goryunov

Nateprov

2014

Proceedings of the International Conference on Strongly Correlated Electron Systems (SCES2013)

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We measured the X-band electron spin resonance (ESR) in the family of ternary Eu pnictides with structure CaAl 2 Si 2type (sp.gr. P3¯m1). Temperature dependences of position and width of resonance line well described by the contribution of the form (T- ) -1/2 ( >0) and  = T N or  =  c-w ; T N ,  c-w -Neel and the Curie-Weiss temperatures). In the case  c-w > T N , experiment obviously indicates the existence of a magnetic phase between the AFM and PM states and relevant quantum critical point. Exchange interaction between localized magnetic moments and the current carriers causes the broadening of the ESR line ΔδH 0 and the gfactor shift Δg K (electronic Knight shift) of Eu 2+ ions relatively free electron. It is known that linewidth of the ESR due the Dzyaloshinsky-Moriya interaction depends on the correlation length  as (/a 0 ) (a 0 -lattice constant), while the symmetric anisotropic interaction as (/a 0 ) 3 . This allows to conclude that experimental results are explained by the dominant contribution of valence and spin fluctuations caused by mentioned symmetrical anisotropic interaction.

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“…Interdisciplinary research has emerged as the preferred method to achieve scientific progress and innovation [10,14,15] because it brings together unique, unrelated talents and resources to address and solve problems that individual investigators could not tackle alone. The synergistic combination promises to yield a more valid understanding of problems, and to provide richer potential findings [11].…”

Section: Advantages Of An Interdisciplinary Approachmentioning

confidence: 99%

“…At the same time, such tests reveal genetic information about individuals and their families, which raise privacy-protection concerns and the potential that data could be misused [15,50]. Although genetics affects almost every aspect of our lives, the public policy that protects these data often lags behind the science [51].…”

Section: Social Legal and Ethical Implicationsmentioning

confidence: 99%

Partnering in Oncogenetic Research – The INHERIT BRCAs Experience: Opportunities and Challenges

et al. 2006

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Today it is common to conduct research in collaboration with colleagues from different disciplines and institutions. The INterdisciplinary HEalth Research International Team on BReast CAncer susceptibility (INHERIT BRCAs), involves Canadian and international experts from diverse fields working with health service providers, patients and collaborators from the World Health Organization and other European networks. Evidence-based information and knowledge transfer drive our efforts to advance genomic research to understand the genetic basis of cancer susceptibility and treatment response. Several goals reveal the interdisciplinary team approach: (a) to estimate the prevalence and penetrance of BRCA1 and BRCA2 mutations and their deleterious impact upon different populations; (b) to pinpoint novel breast cancer susceptibility loci; (c) to assess the efficacy of clinical interventions; (d) to address changes in quality of life and health-related behaviour from the decision to undergo genetics testing and during follow-up; (e) to evaluate legal, social and ethical implications; and, finally; (f) to promote professional and public education by facilitating the transfer of research findings to clinical practice and informing policy makers. The lessons learned by the INHERIT research team and future challenges are presented.

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Organizational challenges in clinical genomic research

Cited by 13 publications

References 4 publications

Genetic epidemiology of diabetes

Genetic epidemiology of diabetes

Spin and Valence Fluctuation in Eu Compounds with CaAl₂Si₂-Structure

Partnering in Oncogenetic Research – The INHERIT BRCAs Experience: Opportunities and Challenges

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Organizational challenges in clinical genomic research

Cited by 13 publications

References 4 publications

Genetic epidemiology of diabetes

Genetic epidemiology of diabetes

Spin and Valence Fluctuation in Eu Compounds with CaAl2Si2-Structure

Partnering in Oncogenetic Research – The INHERIT BRCAs Experience: Opportunities and Challenges

Contact Info

Product

Resources

About

Spin and Valence Fluctuation in Eu Compounds with CaAl₂Si₂-Structure