Organocatalytic Asymmetric Transformations of 3-Substituted 3-Hydroxyisoindolinones

Abstract

Abstract. This Account provides an overview of our group's research in the field of asymmetric organocatalytic transformations generating chiral isoindolinone cores. We describe the synthesis of 3-substituted 3-hydroxyisoindolinones, starting materials for these transformations, comprising a wide range of functional groups, as well as their utilization in asymmetric transformations. We also discuss our efforts in the application of the developed methodology in the synthesis of a known HIV-1 Inhibitor.