Organochlorine pesticides and antioxidant enzymes are inversely correlated with liver enzyme gene expression in Cyprinus carpio

Karaca, Mélis; Varisli, Lokman; Korkmaz, Kemal; Özaydın, Okan; Perçin, Fatih; Orhan, Hilmi

doi:10.1016/j.toxlet.2014.02.013

Cited by 40 publications

(10 citation statements)

References 47 publications

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“…Differences in enzy me activity can be interpreted to accumulat ion of the OCPs and the other many xenobiotics on sediment and also in fish tissues. Similar studies with our study were done in terms of enzyme act ivity changes for carp in Turkey (Ozmen et al 2006;Gungordu and Ozmen 2011;Karaca et al 2014;Agus et al 2015).…”

Section: Resultssupporting

confidence: 86%

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Uckun¹

2017

Turk. J. Fish. Aquat. Sci.

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Residues of organochlorine pesticides (OCPs) were detected in water, sediment and liver tissue samples of the common carp (Cyprinus carpio Linnaeus, 1758) collected from the Ataturk Dam Lake. Ethoxyresorufin O-deethylase, glutathion Stransferase, glutathion reductase, superoxide dismutase, catalase and carboxylesterase activities have been evaluated in liver of Cyprinus carpio. The level of OCPs were determined by Gas Chromatography-M ass Spectrometry. No pesticide residue was determined in the water samples and residues in the sediments were higher than in the fish. In the wet season, the level of pesticides were higher than in the dry season. The concentrations of OCPs were highest in the Akyazı and Bozova areas. Enzyme analysis results showed that the activities were different from region to region and generally higher in Akyazı and Bozova than the other areas. This study is the first study that determines the levels of OCPs of sediment, water and fish in Ataturk Dam Lake and presents pesticide residue levels in the fish samples were above the maximum residue limits so could be a threat to the human health. The presence of OCPs indicates the need for continuous monitoring of the Lake fish population to safeguard the health of the consumers.

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Section: Resultssupporting

confidence: 86%

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Uckun¹

2017

Turk. J. Fish. Aquat. Sci.

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“…In some previous studies, sex-related differences in P450 activity during the reproductive cycle have been reported in other fish (Andersson, 1990;Gray et al, 1991). Moreover, some previous studies showed a good correlation between EROD activity and CYP1A mRNA expression in fish (Quiró et al, 2007;Valdehita et al, 2012), but others also reported a poor correlation between EROD activity and CYP1A mRNA expression (Della Torre et al, 2010;Kammann et al, 2008;Karaca et al, 2014).…”

Section: Discussionmentioning

confidence: 92%

Multi-biomarker responses as indication of contaminant effects in Gambusia affinis from impacted rivers by municipal effluents

Huang

Liu

Liang

et al. 2016

Science of The Total Environment

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“…Zodrow et al (2004) found the lipidosis and hepatocyte hypertrophy. Necrotic foci and lipid droplets in liver of Cyprinus carpio and interactions of antioxidant enzyme activity and lipid peroxidation effect on pesticides were recorded by Oropesa, Cambero, Gómez, Roncero and Soler (2009); Karaca et al, (2014) and Cagdas et al, (2017). Reza et al (2017) additionally found mild changes in vacuole, hemorrhage, and fatty degeneration in the liver tissues of L. rohita treated with 0.058 ppm Envoy 50 SC, whereas moderate hemorrhage, fatty degeneration, lipid droplets were observed for the same fish species at 0.108 ppm.…”

Section: Histopathological Observation In Pesticide Treated Fishmentioning

confidence: 90%

“…The used pesticides in crop fields are harmed to fish and other aquatic biota (Helfrich, Weigmann, Hipkins, & Stinson, 1996). Aquatic life can highly be lethal due to pesticides surface runoff into waterbody (Karaca, Varisli, Korkmaz, Özaydin, Perçin, & Orhan, 2014;Toughill, 1999). Physiological and behavioral changes of fish may cause by the pesticides (Helfrich et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Impact of Kinalax EC on Vital Organ Histomorphology, Blood Cell Structure and Brain Acetylcholinesterase Activity in Silver barb (Barbonymus gonionotus)

Akter¹,

Parvin²,

Jahan³

et al. 2019

AquaSt

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The objective of this research was to evaluate the effects of Kinalax 25 EC, an organophosphate pesticide on silver barb (Barbonymus gonionotus). Histological bioassay of gill, liver and kidney of B. gonionotus, RBC count and acetylcholinesterase (AChE) activity were performed to evaluate the effects of the Kinalax 25 EC at cellular and enzymatic levels. The LC50 value of Kinalax 25 EC was estimated as 0.071 ppm for B. gonionotus. The remarkable changes included missing of gill lamellae, gill clubbing, hyperplasia, nuclear hypertrophy, vacuolation, glomerular expansion, increasing the diameter of renal tubules, hemorrhage, necrosis and pyknosis. Several changes in peripheral nuclear erythrocyte included large lymphocyte, dead cell, fusion of cell, binucleated cell, tear-shaped cell, ghost cell, senile cell and abnormal shape of cell were found. The RBC count was significantly higher (P>0.01) in lower doses compared to higher doses of pesticide in B. gonionotus. The level of AChE activities in B. gonionotus brain significantly decreased (P>0.01) in pesticides treated fish compared to control. The result of this study reveals that the synthetic organophosphorus pesticide adversely affects the organ-specific histology, haematology and brain acetylcholinesterase activities of B. gonionotus.

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Organochlorine pesticides and antioxidant enzymes are inversely correlated with liver enzyme gene expression in Cyprinus carpio

Cited by 40 publications

References 47 publications

Untitled

Untitled

Multi-biomarker responses as indication of contaminant effects in Gambusia affinis from impacted rivers by municipal effluents

Impact of Kinalax EC on Vital Organ Histomorphology, Blood Cell Structure and Brain Acetylcholinesterase Activity in Silver barb (Barbonymus gonionotus)

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