Organochlorine Pesticides and Polychlorinated Biphenyls in Human Adipose Tissue from Northern Tunisia: Current Extent of Contamination and Contributions of Socio-demographic Characteristics and Dietary Habits

Achour, Amani; Derouiche, Abdelkader; Sakly, Mohsen; Rhouma, Khémaïs Ben; Tebourbi, Olfa

doi:10.1007/978-3-319-70548-4_577

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…The concentrations of individual POPs in the diet were in the range of POPs concentrations detected in food items from different locations (Dirtu and Covaci 2010;Polder et al 2010;Törnkvist et al 2011;Cimenci et al 2013;Chen et al 2015). In addition, we previously determined that the concentration of some representative POPs in adipose tissue of mice fed with HF/POPs diet (unpublished data) did not exceed those found in adipose tissue of adult human subjects (Kiviranta et al 2005;Yu et al 2011;Malarvannan et al 2013;Achour et al 2017). Therefore, POP concentrations used in this study were not excessive and should reproduce reallife exposure levels.…”

Section: Selection Of the Mixture Of Popsmentioning

confidence: 86%

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

Benoit

Meugnier

Castelli

et al. 2017

Nat Med

177

163

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The endocrine-derived hormone fibroblast growth factor (FGF) 19 has recently emerged as a potential target for treating metabolic disease. Given that skeletal muscle is a key metabolic organ, we explored the role of FGF19 in that tissue. Here we report a novel function of FGF19 in regulating skeletal muscle mass through enlargement of muscle fiber size, and in protecting muscle from atrophy. Treatment with FGF19 causes skeletal muscle hypertrophy in mice, while physiological and pharmacological doses of FGF19 substantially increase the size of human myotubes in vitro. These effects were not elicited by FGF21, a closely related endocrine FGF member. Both in vitro and in vivo, FGF19 stimulates the phosphorylation of the extracellular-signal-regulated protein kinase 1/2 (ERK1/2) and the ribosomal protein S6 kinase (S6K1), an mTOR-dependent master regulator of muscle cell growth. Moreover, mice with a skeletal-muscle-specific genetic deficiency of β-Klotho (KLB), an obligate co-receptor for FGF15/19 (refs. 2,3), were unresponsive to the hypertrophic effect of FGF19. Finally, in mice, FGF19 ameliorates skeletal muscle atrophy induced by glucocorticoid treatment or obesity, as well as sarcopenia. Taken together, these findings provide evidence that the enterokine FGF19 is a novel factor in the regulation of skeletal muscle mass, and that it has therapeutic potential for the treatment of muscle wasting.

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Section: Selection Of the Mixture Of Popsmentioning

confidence: 86%

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

Benoit

Meugnier

Castelli

et al. 2017

Nat Med

177

163

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“…They are likely to enter the human body via the food chain, threatening the human health. 55,56 Meanwhile, they are likely to contaminate the water and the soil. 57 Therefore, finding an effective detecting method has become the focus of research.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

White-Light-Emitting Materials and Highly Sensitive Detection of Fe³⁺ and Polychlorinated Benzenes Based on Ln-Metal–Organic Frameworks

Huang

Bai

et al. 2018

Crystal Growth & Design

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We employed a rigid bridging-type tetracarboxylic acid molecule, namely, 5,5′-(pyridine-3,5-diyl)diisophthalic acid (H 4 L; containing two isophthalic acid moieties and one pyridine spacer), to construct three new isomorphic Ln-metal–organic framework (Ln-MOF) materials [(CH3)2NH2]2[Ln2(L)2(H2O)2]·2DMF·2H2O (Ln3+ = Tb3+ 1, Eu3+ 2, Gd3+ 3; DMF = N,N-dimethylformamide). Since the pyridyl N atom does not coordinate to Ln3+, the larger pores are observed in the three-dimensional networks of 1–3. On the basis of their photoluminescence properties, the white-light-emitting materials 4–7 with longer fluorescence lifetime (millisecond grade) and higher quantum yield (e.g., 48.29% for 5) are fabricated. We also find that the title Ln-MOF materials not only can selectively sense polychlorinated benzenes, but also can highly sensitively detect the Fe3+ ion (K sv = 7.58 × 104 M–1). This should be associated with these three structural factors in 1–3: the larger π-conjugated structure of L4–; the larger porous structures in 1–3; and the existence of uncoordinated N atom on L4–. The test paper experiments reveal that 1 can be made into the test paper (a naked eye probe) to quickly detect the analytes.

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“…Concentrations of both groups of contaminants are known to be higher in adipose tissue and provide a more representative evaluation of the cumulative internal exposure than those found in different tissues. This is due to the fact that measurement in other tissues (for example blood) will fluctuate during lipid mobilization (i.e., body weight loss, or breeding), rendering adipose tissue samples as preferable bioindicators of body burden, when available (Achour et al, 2017).…”

Section: Levels Of Chlorinated Contaminantsmentioning

confidence: 99%

Concentrations of chlorinated pollutants in adipose tissue of yellow-legged gulls (Larus michahellis) from Spain: Role of gender and age

Vizuete

Hernández‐Moreno

Fidalgo³

et al. 2018

Ecotoxicology and Environmental Safety

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Organochlorine Pesticides and Polychlorinated Biphenyls in Human Adipose Tissue from Northern Tunisia: Current Extent of Contamination and Contributions of Socio-demographic Characteristics and Dietary Habits

Cited by 3 publications

References 21 publications

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

White-Light-Emitting Materials and Highly Sensitive Detection of Fe³⁺ and Polychlorinated Benzenes Based on Ln-Metal–Organic Frameworks

Concentrations of chlorinated pollutants in adipose tissue of yellow-legged gulls (Larus michahellis) from Spain: Role of gender and age

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Organochlorine Pesticides and Polychlorinated Biphenyls in Human Adipose Tissue from Northern Tunisia: Current Extent of Contamination and Contributions of Socio-demographic Characteristics and Dietary Habits

Cited by 3 publications

References 21 publications

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

White-Light-Emitting Materials and Highly Sensitive Detection of Fe3+ and Polychlorinated Benzenes Based on Ln-Metal–Organic Frameworks

Concentrations of chlorinated pollutants in adipose tissue of yellow-legged gulls (Larus michahellis) from Spain: Role of gender and age

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Product

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About

White-Light-Emitting Materials and Highly Sensitive Detection of Fe³⁺ and Polychlorinated Benzenes Based on Ln-Metal–Organic Frameworks