Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in human breast milk and associated health risks to nursing infants in Northern Tanzania

Müller, Mette Helen Bjørge; Polder, Anuschka; Brynildsrud, Ola Brønstad; Karimi, Mahin; Lie, Elisabeth; Manyilizu, Wilbert Bunini; Mdegela, Robbinson Hammerton; Mokiti, F.; Murtadha, M.; Nonga, H. E.; Skaare, Janneche Utne; Lyche, Jan Ludvig

doi:10.1016/j.envres.2017.01.031

Cited by 82 publications

(31 citation statements)

References 67 publications

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“…Previously, we have assessed the postnatal exposure to OCs and BFRs through breast milk for 95 nursing infants. The estimated daily intake of DDTs, dieldrin, nondioxin-like (NDL) PCBs and polybrominated diphenyl ethers (PBDEs) exceeded the health based guidance values in 2%, 6%, 50% and 20% of the nursing infants, respectively (Müller et al 2016;Müller et al 2017). The present study aimed to assess the prenatal exposure to OCPs, PCBs, BFRs, DL compounds and PFASs in Tanzanian infants.…”

Section: Ethicsmentioning

confidence: 95%

“…Samples <1 gram were excluded. The breast milk samples are also included in Müller et al (2016) and Müller et al (2017).…”

Section: Sample Collection and Selectionmentioning

confidence: 99%

“…The analytical method is based on Brevik (Brevik 1978) with further modifications described in Müller et al (2016), Müller et al (2017) and in Polder et al ( 2008).…”

Section: Analysis Of Ocps Pcbs and Bfrsmentioning

confidence: 99%

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Prenatal exposure to persistent organic pollutants in Northern Tanzania and their distribution between breast milk, maternal blood, placenta and cord blood

Müller

Polder

Brynildsrud

et al. 2019

Environmental Research

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Human exposure to persistent organic pollutants (POPs) begins during pregnancy and may cause adverse health effects in the fetus or later in life. The present study aimed to assess prenatal POPs exposure to Tanzanian infants and evaluate the distribution of POPs between breast milk, maternal blood, placenta and cord blood. For assessment of prenatal exposure, 48 maternal blood samples from Mount Meru Regional Referral Hospital (MMRRH), Arusha Tanzania, were analyzed for organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), brominated flame retardants (BFRs), dioxin-like (DL) activity and perfluorinated alkyl substances (PFASs). For evaluation of POPs distribution between maternal/infant compartments, breast milk, placenta and cord blood corresponding to the maternal blood were analyzed for OCPs, PCBs and BFRs. In maternal blood, p,p´-DDE was detected in 100% of the samples ranging between 29 and 1890 ng/g lipid weight (lw). PCB-153 was the only PCB detected in maternal blood, with detection rate of 29% and concentrations up to 116 ng/g lw. BDE-47 was detected in 65% of the maternal blood samples, ranging between

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Section: Ethicsmentioning

confidence: 95%

“…Samples <1 gram were excluded. The breast milk samples are also included in Müller et al (2016) and Müller et al (2017).…”

Section: Sample Collection and Selectionmentioning

confidence: 99%

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Prenatal exposure to persistent organic pollutants in Northern Tanzania and their distribution between breast milk, maternal blood, placenta and cord blood

Müller

Polder

Brynildsrud

et al. 2019

Environmental Research

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“…As a result, examples of literature about negative effects of DDT in humans in Africa include those in breast milk. Organochlorine pesticides (OCPs) were reported to be present in human breast milk, thus causing health risk to nursing infants in northern Tanzania in 2017 by Müller et al [20]; in South Africa in 2006 by Bouwman et al [21]; and also reported in milk and serum of Ghanaian farmers [22]. Furthermore, long-term effects of DDT exposure not only affected semen, fertility, and sexual function of farm workers in South Africa [23], but also caused DDT genotoxicity to cultured lymphocytes in Tunisia [24] and reduced half-life of paracetamol in highly exposed mothers in Zimbabwe [25].…”

Section: Negative Effects Of Ddtmentioning

confidence: 99%

Pesticides, Anthropogenic Activities, History and the Health of Our Environment: Lessons from Africa

Manyilizu¹

2019

Pesticides - Use and Misuse and Their Impact in the Environment

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This chapter describes the historical events related to pesticide use. The description of events focuses on human activities that necessitated the use of chemical agents for pest control to protect crops, and animals including humans in African countries. The description covers the common pests in Africa and the need for pest control using pesticides. History of pesticide use in Africa and the ban of organochlorines are covered. Controversies under discussion in Africa and the current trend of pesticide use in Africa are part of the chapter as well as pesticide import and supply. Hazard and risk of exposure of biological organisms including humans to pesticides due to anthropogenic activities in Africa and pros and cons of pesticide use in Africa are covered.

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“…Improper use of pesticides has been linked to high levels of residues by persistent organic pollutants such as Dichlorodiphenyltrichloroethane (DDT) in tilapia fish from Lake Tanganyika [19], severe reductions in populations of beneficial insects such as pollinator bees and parasitoids [20], contamination of surface water in Lake Kivu with malathion, metalaxyl and carbendazim [21], human diseases and suicide [16,22]. Pesticide residues have been reported in breast milk [23][24][25], fruits and vegetables [26].…”

Section: Introductionmentioning

confidence: 99%

Pesticide Use Practices in Root, Tuber and Banana Crops by Smallholder Farmers in Rwanda and Burundi

Okonya

Petsakos

Suárez

et al. 2018

Preprint

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Misuse and poor handling of chemical pesticides in agriculture is hazardous to the health of farmers, consumers and the environment. We studied the pest and disease management practices and the type of pesticides used in four root, tuber and banana (RTB) crops in Burundi and Rwanda through in-depth interviews with a total of 811 smallholder farmers. No chemical pesticides were used in banana in either Rwanda and Burundi, whereas the use of insecticides and fungicides in potato is quite frequent. Nearly all insecticides and about one third of the fungicides used are moderately hazardous. Personal protective equipment is used by less than a half of the interviewed farmers in both countries. Reported cases of death due to self- or accidental poisoning among humans and domestic animals in the previous 12 months were substantial in both countries. Training of farmers and agrochemical retailers in safe use of pesticide and handling, and use of integrated pest management approaches to reduce pest and disease damage is recommended.

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Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in human breast milk and associated health risks to nursing infants in Northern Tanzania

Cited by 82 publications

References 67 publications

Prenatal exposure to persistent organic pollutants in Northern Tanzania and their distribution between breast milk, maternal blood, placenta and cord blood

Prenatal exposure to persistent organic pollutants in Northern Tanzania and their distribution between breast milk, maternal blood, placenta and cord blood

Pesticides, Anthropogenic Activities, History and the Health of Our Environment: Lessons from Africa

Pesticide Use Practices in Root, Tuber and Banana Crops by Smallholder Farmers in Rwanda and Burundi

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