Organophosphate pesticide trichlorfon induced neurotoxic effects in freshwater silver catfish Rhamdia quelen via disruption of blood-brain barrier: Implications on oxidative status, cell viability and brain neurotransmitters

Baldissera, Matheus D.; Souza, Carine F.; Descovi, Sharine N.; Zanella, Renato; Prestes, Osmar D.; Silva, Aleksandro S. Da; Baldisserotto, Bernardo

doi:10.1016/j.cbpc.2018.12.006

Cited by 19 publications

(15 citation statements)

References 39 publications

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“…As previously mentioned, xenobiotic efflux mechanisms exist at the BBB of many fish, but some environmental toxicants may cross the BBB and remain there at concentrations too high to export, or they may damage the BBB. Triclorfon and Aflatoxin B1 both cause increases in permeability of the BBB in silver catfish (Rhamdia quelen) [183,210]. These studies also found changes in behavior, though the link between BBB and behavior is uncertain for all fish [183,210].…”

Section: Factors Altering Piscine Bbb Function 631 Environmental Contaminantsmentioning

confidence: 88%

“…Although early studies of the fish BBB focused on multiple fish species, literature from the past 10-20 years has focused almost exclusively on teleosts, and among those primarily zebrafish (Danio rerio) [180][181][182][183]. This is due to the zebrafish's utility as a model organism for humans.…”

Section: The Blood-brain Barrier Of Fishmentioning

confidence: 99%

“…This is due to the zebrafish's utility as a model organism for humans. Outside human health applications, a small number of studies have examined the BBB of other teleost species for environmentally relevant issues such as pollution and aquaculture [183][184][185]. However, many environmental studies address whether certain compounds cross the BBB rather than how such compounds or environmental conditions impact the BBB structure, physiology, and function, as well as the overall biology of fish.…”

Section: The Blood-brain Barrier Of Fishmentioning

confidence: 99%

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Form and Function of the Vertebrate and Invertebrate Blood-Brain Barriers

Dunton

Göpel

et al. 2021

IJMS

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The need to protect neural tissue from toxins or other substances is as old as neural tissue itself. Early recognition of this need has led to more than a century of investigation of the blood-brain barrier (BBB). Many aspects of this important neuroprotective barrier have now been well established, including its cellular architecture and barrier and transport functions. Unsurprisingly, most research has had a human orientation, using mammalian and other animal models to develop translational research findings. However, cell layers forming a barrier between vascular spaces and neural tissues are found broadly throughout the invertebrates as well as in all vertebrates. Unfortunately, previous scenarios for the evolution of the BBB typically adopt a classic, now discredited ‘scala naturae’ approach, which inaccurately describes a putative evolutionary progression of the mammalian BBB from simple invertebrates to mammals. In fact, BBB-like structures have evolved independently numerous times, complicating simplistic views of the evolution of the BBB as a linear process. Here, we review BBBs in their various forms in both invertebrates and vertebrates, with an emphasis on the function, evolution, and conditional relevance of popular animal models such as the fruit fly and the zebrafish to mammalian BBB research.

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Section: Factors Altering Piscine Bbb Function 631 Environmental Contaminantsmentioning

confidence: 88%

Section: The Blood-brain Barrier Of Fishmentioning

confidence: 99%

Section: The Blood-brain Barrier Of Fishmentioning

confidence: 99%

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Form and Function of the Vertebrate and Invertebrate Blood-Brain Barriers

Dunton

Göpel

et al. 2021

IJMS

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“…Although the toxicity of β‐cypermethrin to crustaceans is well known, it is still neglected in aquaculture (Mu et al, 2017; Wendt‐Rasch et al, 2003). Trichlorfon is an organophosphorus insecticide used against both internal and external parasitic diseases of aquatic organisms and to reduce the overgrowth of zooplankton (Baldissera et al, 2019; Chang, Lee, Liu, & Cheng, 2006). Although numerous studies have evaluated the effect of insecticide residues in various aspects such as ecosystem destruction and health status of species, most of the assessment focused on the high‐toxicity and the acute effects (Chagnon et al, 2015; Ham et al, 2020; Mu et al, 2017; Wang et al, 2020; Wendt‐Rasch et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Hepatopancreatic necrosis disease (HPND) in Chinese mitten crab Eriocheir sinensis tightly linked to low concentration of two insecticides

Shen

Zhang

et al. 2020

Aquaculture Research

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To date, hepatopancreatic necrosis disease (HPND) in Eriocheir sinensis is causing huge financial losses to the aquaculture industry while the cause of HPND remains unclear. Our previous study has implied that HPND is probably relevant to the damages caused by insecticide residues. In this work, the comparative studies regarding histopathology and trends in immune‐related/detoxifying enzymes activities of the crabs were performed between exposed to the low concentration of insecticides (i.e. β‐cypermethrin 8.52 × 10−12 g/L and trichlorfon 5 × 10−5 g/L) in a long‐term (90‐days) and suffered from HPND. The concentration was obtained by a median‐lethal concentration (LC50) and a safe concentration (SC), and it was 10 times lower than the safe concentration in this experiment. This work's principal aim was to investigate the potential chronic effects of low concentrations of insecticides exposure on crabs and their relevance with HPND. As a result, crabs exposed to the low concentration of insecticides caused similar clinical symptoms and severity in hepatopancreas and other tissue damages like HPND. Meanwhile, catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), acid phosphatase (ACP), alkaline phosphatase (AKP), lysozyme (LZM) and carboxylesterase (CarE) enzymatic activity increased after exposure to the two insecticides and then decreased in the later stages, while the activity of glutathione S‐transferase (GSTs) has barely changed. Results of enzymatic activity indicated that the two insecticides induced oxidative damage to the hepatopancreas of E. sinensis. These evidence indicated that the chronic damage caused by the low concentration of insecticides, which is considered insecticide residue, might be part of the causes of HPND in crabs. The present work may enhance our understanding of the pathogenesis of HPND and provide a theoretical basis for the management of intensive crab aquaculture.

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“…Organophosphorus pesticides (OPs), such as Trichlorfon, have been thoroughly used in agriculture due to their powerful insecticidal ability (Ma et al, 2018 ). However, due to its inhibition of acetylcholinesterase (AChE), the key enzyme of nerve conduction (Baldissera et al, 2019 ), it also poses a major threat to overall health (Soreq and Seidman, 2001 ; Shi et al, 2016b ). Consequently, quick and sensitive probes of OPs in food production have turned out to be of considerable importance.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a Sensor Based on Biomass Porous Carbon/Covalent-Organic Frame Composites for Pesticide Residues Detection

et al. 2020

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In this work, a covalent-organic framework with high carbon and nitrogen content microstructures (named COF-LZU1), assisted by 3D nitrogen-containing kenaf stem composites (represented as COF-LZU1/3D-KSCs), was constructed. Moreover, it was utilized for immobilizing acetylcholinesterase (AChE) for identifying trichlorfon, a commonly applied organophosphorus (OP) pesticide. The development of COF-LZU1/3D-KSC was affirmed by SEM, PXRD, and EDXS. The findings confirmed that COF-LZU1 microstructures were uniformly developed on 3D-KSC holes using a one-step synthesis approach, which can substantially enhance the effective surface area. Also, the COF-LZU1/3D-KSC composite contains not only the nitrogen element in COF-LZU1 but also the nitrogen element in 3D-KSC, which will greatly improve the biocompatibility of the material. The AChE/COF-LZU1/3D-KSC integrated electrode was fabricated by directly fixing a large amount of AChE on the composite. At the same time, the integrated electrode had good detection efficiency for trichlorfon. Improved stabilization, a wide-linear-range (0.2-19 ng/mL), and a lower detection limit (0.067 ng/mL) have been displayed by the sensor. Therefore, this sensor can be used as an important platform for the on-site detection of OP residue.

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Organophosphate pesticide trichlorfon induced neurotoxic effects in freshwater silver catfish Rhamdia quelen via disruption of blood-brain barrier: Implications on oxidative status, cell viability and brain neurotransmitters

Cited by 19 publications

References 39 publications

Form and Function of the Vertebrate and Invertebrate Blood-Brain Barriers

Form and Function of the Vertebrate and Invertebrate Blood-Brain Barriers

Hepatopancreatic necrosis disease (HPND) in Chinese mitten crab Eriocheir sinensis tightly linked to low concentration of two insecticides

Preparation of a Sensor Based on Biomass Porous Carbon/Covalent-Organic Frame Composites for Pesticide Residues Detection

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