Organophosphorus Compound Poisoning;

Abstract

. Objective: 1) To have an overview of epidemiological factors. 2) To determine the outcome of victims. Study design:Descriptive study. Setting: MU-III Allied Hospital Faisalabad. Period: From June 2007 to Dec 2008 Materials and Methods: 484 consecutivepatients who were admitted, from June 2007 to December 2008, in Medical unit III with history of having organophosphorus poisoning wereanalyzed for the epidemiological factors, time to arrive in the hospital, conscious level, mode of poisoning (homicidal, suicidal or accidental)treatment given and outcome. Results: The results of the study showed that age 14-30 years is the major group involved in poisoning 87.9%as compared to ages 31-45years (10.5%) and age more then 45 years (12%), also age group 14-30 years is having more suicidal tendenciesas well as accidental poisoning and these tendencies decrease with increasing age (p value=0.000). Male victims are more as compared tofemale victims (52.9% vs. 46.7%) in the study group. Suicidal tendencies as well as homicidal poisoning is more in female (n= 127 and 44,respectively) while accidental poisoning is more in male population (n=106), (p value=0.001). Urban population is more at risk of poisoning inall three, homicidal, suicidal and accidental, as compared to the rural population (p vale=0.018). Importantly in study is showed that out comeof the poisoning from organophosphorus is directly proportional to the interval between poisoning and presentation in emergency ward (p value=0.000), conscious level of the victim (p value = 0.000) and does not depend upon the mode of management (oxime or atropine) (p value 0.026).Conclusions: Younger urban population have increased tendency of poisoning with a dominance of female population. Rapidity of treatment,time to arrival to hospital and conscious level at presentation are the factors deciding outcome of a given patient rather than the mode oftreatment (oximes and atropine both are equally effective).