Organosulfur compounds and cardiovascular disease

Vazquez-Prieto, Marcela Alejandra; Miatello, Roberto

doi:10.1016/j.mam.2010.09.009

Cited by 108 publications

(65 citation statements)

References 48 publications

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“…Organosulfur compounds found abundantly in cruciferous vegetables may also play a role. Isothiocyanates are organosulfur compounds that have been extensively researched for their anticancer properties 14, 54, 55, 56. However, accumulating evidence suggests sulforaphane, a compound within the isothiocyanate group, may have beneficial effects on vascular damage via the blockade of oxidative stress and/or inhibition of advanced glycation end products 57, 58.…”

Section: Discussionmentioning

confidence: 99%

“…Some of these naturally occurring compounds include carotenoids, polyphenols, organosulfur compounds, and nitrogen‐containing compounds 12, 13, 14, 15. Different types of vegetables contain different levels of these putative protective components.…”

Section: Introductionmentioning

confidence: 99%

“…Different types of vegetables contain different levels of these putative protective components. For example, cruciferous vegetables, such as cabbage, brussels sprouts, cauliflower, and broccoli, and allium vegetables, such as onions, leek, and garlic, are rich sources of organosulfur compounds, which are proposed to be beneficial for cardiovascular health 14. Another example is leafy green vegetables, such as spinach and lettuce, which are a rich source of the nitrogen‐containing compound, nitrate.…”

Section: Introductionmentioning

confidence: 99%

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Cruciferous and Total Vegetable Intakes Are Inversely Associated With Subclinical Atherosclerosis in Older Adult Women

Blekkenhorst

Bondonno

Lewis

et al. 2018

JAHA

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BackgroundDietary patterns rich in fruits and vegetables are considered to reduce atherosclerotic disease presentation and are reported to be inversely associated with subclinical measures of atherosclerosis, such as carotid artery intima‐media thickness (IMT) and plaque. However, the effect of vegetable intake alone, and relationships to specific types of vegetables containing different phytochemical profiles, is important. The aim of this study was to investigate the associations of total vegetable intake and specific vegetables grouped according to phytochemical constituents with common carotid artery IMT (CCA‐IMT) and carotid plaque severity in a cohort of older adult women (aged ≥70 years).Methods and ResultsTotal vegetable intake was calculated at baseline (1998) using a validated food frequency questionnaire. Vegetable types included cruciferous, allium, yellow/orange/red, leafy green, and legumes. In 2001, CCA‐IMT (n=954) and carotid focal plaque (n=968) were assessed using high‐resolution B‐mode carotid ultrasonography. Mean (SD) total vegetable intake was 199.9 (78.0) g/d. Women consuming ≥3 servings of vegetables each day had ≈4.6% to 5.0% lower mean CCA‐IMT (P=0.014) and maximum CCA‐IMT (P=0.004) compared with participants consuming <2 servings of vegetables. For each 10 g/d higher in cruciferous vegetable intake, there was an associated 0.006 mm (0.8%) lower mean CCA‐IMT (P<0.01) and 0.007 mm (0.8%) lower maximum CCA‐IMT (P<0.01). Other vegetable types were not associated with CCA‐IMT (P>0.05). No associations were observed between vegetables and plaque severity (P>0.05).ConclusionsIncreasing vegetables in the diet with a focus on consuming cruciferous vegetables may have benefits for the prevention of subclinical atherosclerosis in older adult women.Clinical Trial Registration URL: http://www.anzctr.org.au. Unique identifier: ACTRN12615000750583.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cruciferous and Total Vegetable Intakes Are Inversely Associated With Subclinical Atherosclerosis in Older Adult Women

Blekkenhorst

Bondonno

Lewis

et al. 2018

JAHA

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“…IP, immunoprecipitation; IB, immunoblotting. vide important nutrients and health-promoting phytochemicals, including quercetin (24,25).…”

Section: Discussionmentioning

confidence: 99%

Toll-like Receptors as a Target of Food-derived Anti-inflammatory Compounds

Shibata

Nakashima

Honda

et al. 2014

Journal of Biological Chemistry

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Background: Vegetable-rich diets are associated with the reduced risk of inflammatory diseases. Results: Iberin, an isothiocyanate compound from cabbage, targeted TLRs, disrupted TLR dimerization, and inhibited the inflammatory responses. Conclusion: The TLR dimerization step is a target of food-derived anti-inflammatory compounds. Significance: These findings extend our understanding of how isothiocyanates show their medical benefits as anti-inflammatory food components.

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“…The plant is a rich source of ascorbic acid, polyphenols, flavonoids, and organic natural sulphur (methyl sulfonyl methane) (Singh and Singh, 2014). Organosulphur compounds have been shown to have diverse biological beneficial effects, such as antioxidant effects and anti-inflammatory properties (Vazquez-Prieto and Miatello, 2010). Therefore, the antioxidant effects of A. hookeri in the current study may be related to the presence of organosulphur compounds.…”

Section: Discussionmentioning

confidence: 71%

<i>In Vitro </i>Analysis of the Immunomodulating Effects of <i>Allium Hookeri </i>on Lymphocytes, Macrophages, and Tumour Cells

Lee

Jeong

et al. 2017

Jpn. Poult. Sci.

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The present study investigated the effects of ethanol extracts of Allium hookeri (leaf, root, and fermented root) on parameters of innate immunity, tumour cell viability and antioxidant effect in vitro. Innate immunity was measured by spleen lymphocyte proliferation, nitric oxide production by chicken macrophage HD11 cells and suppressive effect on tumour cell viability was assessed using chicken RP9 cells. Free radical scavenging capacity as a measure of antioxidant capacity was determined by 0.15 mM of DPPH solution. In vitro culture of chicken spleen lymphocytes with ethanol extract of Allium hookeri (62.5-500 μg/mL) significantly induced higher proliferation compared with media control. Stimulation of macrophages with ethanol extract of Allium hookeri (62.5-500 μg/mL) showed increased Nitric oxide production. Tumor cells growth was significantly inhibited by extracts of Allium hookeri at 15.6-125 μg/mL compared with medium control and all extracts exhibited greater than 80% scavenging activity at 1000 μg/mL compared with ethanol vehicle control. Above all, fermented root extracts showed strongest effects on antioxidant activity compared to leaf and root extracts.

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Organosulfur compounds and cardiovascular disease

Cited by 108 publications

References 48 publications

Cruciferous and Total Vegetable Intakes Are Inversely Associated With Subclinical Atherosclerosis in Older Adult Women

Cruciferous and Total Vegetable Intakes Are Inversely Associated With Subclinical Atherosclerosis in Older Adult Women

Toll-like Receptors as a Target of Food-derived Anti-inflammatory Compounds

<i>In Vitro </i>Analysis of the Immunomodulating Effects of <i>Allium Hookeri </i>on Lymphocytes, Macrophages, and Tumour Cells

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