Organosulfur Compounds as Nutraceuticals

Гончаров, Н. В.; Orekhov, Alexander N.; Voitenko, Natalia; Ukolov, A. I.; Jenkins, Richard O.; Avdonin, P. V.

doi:10.1016/b978-0-12-802147-7.00041-3

Cited by 28 publications

(17 citation statements)

References 104 publications

(86 reference statements)

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“…Despite some progress in studying the possibility of enhancing the antioxidant properties of albumin, the development of the methods for correcting oxidative stress taking into account this ability of the protein is still in its infancy. Recently, such classes of compounds as thiol antioxidants ( n -acetylcysteine, carbocysteine and erdosteine), superoxide dismutase mimetics (magnesium-containing porphyrins), NADPH oxidase inhibitors (apocinin, diphenyliod), setanaxib traps (disulfenton sodium), activators of the transcription factor Nrf2 (Sulforaphane, Bardoxelone methyl, Dimethylfumarate) have been actively tested or are already being used to reduce oxidative stress [ 168 , 169 , 170 , 171 ]. It might be that in the future it will be possible to create the complex therapy for oxidative stress management taking into account the functional properties of albumin.…”

Section: Antioxidant Properties Of Albumin: Practical Applicationmentioning

confidence: 99%

The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin

et al. 2020

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As a carrier of many biologically active compounds, blood is exposed to oxidants to a greater extent than the intracellular environment. Serum albumin plays a key role in antioxidant defence under both normal and oxidative stress conditions. This review evaluates data published in the literature and from our own research on the mechanisms of the enzymatic and non-enzymatic activities of albumin that determine its participation in redox modulation of plasma and intercellular fluid. For the first time, the results of numerous clinical, biochemical, spectroscopic and computational experiments devoted to the study of allosteric modulation of the functional properties of the protein associated with its participation in antioxidant defence are analysed. It has been concluded that it is fundamentally possible to regulate the antioxidant properties of albumin with various ligands, and the binding and/or enzymatic features of the protein by changing its redox status. The perspectives for using the antioxidant properties of albumin in practice are discussed.

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Section: Antioxidant Properties Of Albumin: Practical Applicationmentioning

confidence: 99%

The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin

et al. 2020

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“…Sulfides, disulfides, and other organosulfur compounds (OSC) are widely present in our bodies and the natural environment. They can interact with or neutralize ROS and determine the thiol/disulfide redox states in signaling and sensing, thus maintaining our bodies healthy or contributing to development of diseases [253].…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

“…Nevertheless, oxygen is not always available in plenty amounts, for example, in ischemic states. In such cases, some artificial or natural electrophiles (electron acceptors) could be helpful, and this property has been exploited for elaborating a new type of therapeutics with the help of OSC, polyphenols, and other nutraceuticals [250,253]. Nutraceuticals could serve not only as electrophiles, but also as a kind of "pro-electrophilic drugs" that become electrophilic in response to oxidation with subsequent activation of the Keap1/Nrf2/ARE transcription pathway and synthesis of endogenous antioxidant "phase 2" enzymes [252].…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Гончаров

Nadeev

Jenkins

et al. 2017

Oxidative Medicine and Cellular Longevity

165

115

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Endothelium is a community of endothelial cells (ECs), which line the blood and lymphatic vessels, thus forming an interface between the tissues and the blood or lympha. This strategic position of endothelium infers its indispensable functional role in controlling vasoregulation, haemostasis, and inflammation. The state of endothelium is simultaneously the cause and effect of many diseases, and this is coupled with modifications of endothelial phenotype represented by markers and with biochemical profile of blood represented by biomarkers. In this paper, we briefly review data on the functional role of endothelium, give definitions of endothelial markers and biomarkers, touch on the methodological approaches for revealing biomarkers, present an implicit role of endothelium in some toxicological mechanistic studies, and survey the role of reactive oxygen species (ROS) in modulation of endothelial status.

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“…Also, SFN has been shown to reduce muscle inflammation by acting as an indirect antioxidant and anti-inflammatory compounds, by activating the Nrf2induced inhibition of nuclear factor-kappa B (NF-κB) signaling pathway (53). Regardless of whether OSC comes from Allium or Brassica genus, it seems to serve the same role against inflammation (54).…”

Section: Inflammation Induced By Exogenous Stimulimentioning

confidence: 99%

Organosulfur Compounds: A Review of Their Anti-inflammatory Effects in Human Health

Ruhee

Roberts

et al. 2020

Front. Nutr.

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Phytonutrients are widely recognized for providing protective human health benefits. Among the phytonutrients, epidemiological and experimental studies show that dietary organosulfur compounds (OSC) play a significant role in preventing various human pathological progressions, including chronic inflammation, by decreasing inflammatory mediators such as nitric oxide (NO), prostaglandin (PG)E 2 , interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and IL-17, which are all typical hallmarks of inflammation. Evidence supports OSC in reducing the expression of these markers, thereby attenuating chronic inflammatory processes. Nuclear factor-kappa B (NF-κB) is a key regulating factor during inflammation, and novel evidence shows that OSC downregulates this transcriptional factor, thus contributing to the anti-inflammatory response. In vitro and in vivo studies show that inflammation is mechanistically linked with acute and chronic pathological conditions including cancer, diabetes, obesity, neural dysfunction, etc. Furthermore, a considerable number of experiments have demonstrated that the anti-inflammatory properties of OSC occur in a dose-dependent manner. These experiments also highlight indirect mechanisms as well as potent co-functions for protective roles as antioxidants, and in providing chemoprotection and neuroprotection. In this brief review, we provided an overview of the anti-inflammatory effects of OSC and elucidated probable mechanisms that are associated with inflammation and chronic disorders.

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Organosulfur Compounds as Nutraceuticals

Cited by 28 publications

References 104 publications

The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin

The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Organosulfur Compounds: A Review of Their Anti-inflammatory Effects in Human Health

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