Organosulfur Compounds in Fermented Garlic Extracts and the Effects on Alcohol Induced Cytotoxicity in CYP2E1-Transfected HepG2 Cells

정은봉,; 최지휘,; 유희종,; 김기호,; 이성구,; 황용일,; 이승현,

doi:10.3746/jkfn.2013.42.3.342

Cited by 14 publications

(6 citation statements)

References 24 publications

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“…These OSCs have been reported to increase antioxidants such as glutathione, catalase, and GSH peroxidase in HFD‐induced obese mice (Lin & Yin, ). Various garlic preparations, including crude garlic (Abdel‐Salam & Sayed, ), garlic oil (El‐Khayat et al, ), and lactic acid bacteria‐fermented garlic extracts (LAFGE) (Choi et al, ; Jung et al, ), have been shown to promote hepatoprotection. Depending on the lactic acid bacteria, LAFGE has been reported to contain varying amount of OSCs including alliin, cycloalliin, S‐ethyl cysteine (SEC), SAC, and S‐methylcysteine (SMC) (Jung et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Various garlic preparations, including crude garlic (Abdel‐Salam & Sayed, ), garlic oil (El‐Khayat et al, ), and lactic acid bacteria‐fermented garlic extracts (LAFGE) (Choi et al, ; Jung et al, ), have been shown to promote hepatoprotection. Depending on the lactic acid bacteria, LAFGE has been reported to contain varying amount of OSCs including alliin, cycloalliin, S‐ethyl cysteine (SEC), SAC, and S‐methylcysteine (SMC) (Jung et al, ). Indeed, the hepatoprotective effect of LAFGE has been well‐reported in several liver disease models (Guan et al, ; Lee et al, ; Shin et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…These OSCs have been reported to increase antioxidants such as glutathione, catalase, and GSH peroxidase in HFD-induced obese mice (Lin & Yin, 2008). Various garlic preparations, including crude garlic (Abdel-Salam & Sayed, 2012), garlic oil (El-Khayat et al, 2010), and lactic acid bacteria-fermented garlic extracts (LAFGE) (Choi et al, 2014;Jung et al, 2013), have been shown to promote hepatoprotection.…”

mentioning

confidence: 99%

“…Depending on the lactic acid bacteria, LAFGE has been reported to contain varying amount of OSCs including alliin, cycloalliin, S-ethyl cysteine (SEC), SAC, and S-methylcysteine (SMC) (Jung et al, 2013). Indeed, the hepatoprotective effect of LAFGE has been well-reported in several liver disease models (Guan et al, 2018;Lee et al, 2016;Shin et al, 2014).…”

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confidence: 99%

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Hepatoprotective effect of a novel lactic acid‐fermented garlic extract functional food product against acute liver injury

Kim

et al. 2020

Food Science & Nutrition

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Lactic acid‐fermented garlic extract (LAFGE) has been shown to have hepatoprotective role in liver diseases. This study was conducted to evaluate the efficacy of a new LAFGE‐based hepatoprotective functional food product (named D‐18‐007) formulated with other additive components, including l‐arginine, l‐ornithine, and the leaf extract of licorice and artichoke. In a rat model of d‐galactosamine(GalN)/LPS‐induced liver injury, the survival was significantly higher in animals treated with D‐18‐007 than in animals treated with LAFGE. The hepatic injury was alleviated by either LAFGE or D‐18‐007, but the overall effect was more significant in D‐18‐007, as shown by the necrosis, histology, and serum analyses. Also, the decrease in GalN/LPS‐induced lipid peroxidation in the liver tissue was more significant in D‐18‐007 than LAFGE. The decrease in IL‐6 protein in the liver was similar between LAFGE and D‐18‐007. Moreover, we compared the amount of the bile in normal animals and found that D‐18‐007 has better choleretic activity than LAFGE. Using this acute liver injury model, our results suggest that D‐18‐007 has an enhanced hepatoprotective effect in acute liver injury compared with LAFGE alone.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Hepatoprotective effect of a novel lactic acid‐fermented garlic extract functional food product against acute liver injury

Kim

et al. 2020

Food Science & Nutrition

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“…We previously prepared a fermented garlic extract using LAB to improve garlic-specific pungent taste and aroma, enhance functional properties of garlic, and overcome disadvantages during the manufacturing process of AGE. We previously found that lactic acid-fermented garlic extract (LAFGE) effectively protected alcohol-induced liver injury in an in vivo model by enhancing several antioxidant compounds in garlic during fermentation, including cycloalliin, S-allyl cysteine, S-methyl cysteine, and S-ethyl cysteine (14).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of lactic acid-fermented garlic extract against acetaminophen-induced acute liver injury in rats

Lee

Lim

Lee

et al. 2016

Food Sci Biotechnol

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The aim of the present study was to investigate the protective effect of fermented garlic extract by lactic acid bacteria (LAFGE) against acetaminophen (AAP)-induced acute liver injury in rats. Here we demonstrated that rats treated with LAFGE exhibit resistance to AAP-induced liver injury accompanied by lowered plasma alanine amino transferase levels and decreased proinflammatory responses. This function of LAFGE is linked to its capacity of suppressing AAP-induced apoptosis in the liver, partly via the inhibition of MAPK phosphorylation as well as down-regulation of p53. Our findings reveal that LAFGE modulates the signaling pathways involved in hepatic apoptosis through cellular redox control, as indicated by the inhibition of lipid peroxidation, glutathione and ATP depletion, and the elevation of antioxidant enzyme activities. Taken together, these findings indicate that LAFGE ameliorates AAP-induced liver injury by preventing oxidative stress-mediated apoptosis, thereby establishing LAFGE as a potential supplement in the treatment of AAP-induced liver injury.

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Efficacy and safety of fermented garlic extract on hepatic function in adults with elevated serum gamma-glutamyl transpeptidase levels: a double-blind, randomized, placebo-controlled trial

et al. 2016

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Organosulfur Compounds in Fermented Garlic Extracts and the Effects on Alcohol Induced Cytotoxicity in CYP2E1-Transfected HepG2 Cells

Cited by 14 publications

References 24 publications

Hepatoprotective effect of a novel lactic acid‐fermented garlic extract functional food product against acute liver injury

Hepatoprotective effect of a novel lactic acid‐fermented garlic extract functional food product against acute liver injury

Hepatoprotective effects of lactic acid-fermented garlic extract against acetaminophen-induced acute liver injury in rats

Efficacy and safety of fermented garlic extract on hepatic function in adults with elevated serum gamma-glutamyl transpeptidase levels: a double-blind, randomized, placebo-controlled trial

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