Origin and distribution of 3-methoxy-4-hydroxyphenylglycol in body fluids

DeMet, Edward M.; Halaris, Angelos

doi:10.1016/0006-2952(79)90611-7

Cited by 110 publications

(24 citation statements)

References 79 publications

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“…MHPG is a major metabolite of NE in the brain and a reliable index of the central NE activity (DeMet and Halaris, 1979). To regulate brain NE activity is important, since several types of stressors have been linked to the increase of NE activity, namely increases in the MHPG level (DeMet and Halaris, 1979). We previously confirmed that 6 h fasting significantly increased MHPG levels in the diencephalon and telencephalon of chicks (Hamasu et al, 2012) and same tendency was observed in the preliminary experiment as shown above.…”

Section: Introductionsupporting

confidence: 77%

“…To focus on the effect of APP on the stress response, we used fasting as a stressful condition same as the preliminary experiment. MHPG is a major metabolite of NE in the brain and a reliable index of the central NE activity (DeMet and Halaris, 1979). To regulate brain NE activity is important, since several types of stressors have been linked to the increase of NE activity, namely increases in the MHPG level (DeMet and Halaris, 1979).…”

Section: Introductionmentioning

confidence: 99%

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Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks

et al. 2012

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* Both authors contributed equally to this work Alaska pollack protein (APP) reduces serum triacylglycerol and body fat accumulation by the enhancement of basal energy expenditure through fast-twitch muscle hypertrophy in rats. However, the effects of APP on brain function have not yet been clarified. In the present study, we investigated the effects of orally administered APP on the brain levels of 3-methoxy-4-hydroxyphenylglycol (MHPG), which is a metabolite of norepinephrine (NE) and can be used as an index of NE activity, in fasting chicks. Fasting stress significantly decreased plasma glucose, uric acid, triacylglycerol, proline and ornithine while MHPG levels in the brain and plasma corticosterone concentration were not affected. APP dose-dependently decreased MHPG level in the diencephalon, telencephalon and optic lobe. Plasma uric acid, alanine, β-alanine, arginine, anserine, aspartate, asparagine, glycine, histidine, isoleucine, leucine, lysine, 1-methylhistidine, 3-methylhisitidine, ornithine, proline, taurine and valine were dose-dependently increased with the increase of APP. It has been reported that some of them are known to centrally reduce the stress-induced behaviors of chicks. These results suggest that orally administered APP could influence brain NE activity through increase in amino acids to protect against stress conditions.

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Section: Introductionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks

et al. 2012

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“…MHPG from arterial to internal jugular venous sampling sites led to suggestions that measurements of this metabolite in urine, plasma, and CSF would provide a means for assessing the activity of central nervous noradrenergic systems (DeMet and Halaris, 1979;Maas et al, 1979;Elsworth et al, 1982).…”

Section: Catecholamine Metabolismmentioning

confidence: 99%

Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine

2004

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“…Its production involves three enzymes: monoamine oxidase (MAO) catechol-O-methyltransferase (COMT) and aldehyde reductase (AR). Levels of MHPG in peripheral body fluids were found to be related to brain levels and to be correlated with each other De Met and Halaris, 1979; Jimerson etal., 1981;Kopin et al, 1982;Karege et al, 1984], Practical reasons tend to favor determination of MHPG in the plasma [Roy et al 1986;Ko et al, 1988], Even if plasma MHPG levels are largely derived from peripheral sources, it seems likely that changes in plasma MHPG may reflect central nervous system (CNS) changes in NE activity , Plasma MHPG is found in free and conjugated form. Although it is the free form which predominates in the CNS and equilibrates with plasma in man, conju gated and total plasma MHPG were also found to corre late with cerebrospinal fluid (CSF) total MHPG and CSF NE levels , Most psychiatric studies have been concerned with urinary and CSF MHPG.…”

mentioning

confidence: 97%

Plasma Levels of 3-Methoxy-4-Hydroxyphenylglycol in Depressed Patients Compared with Normal Controls

Azorin

Raucoules²,

Valli³

et al. 1990

Neuropsychobiology

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Plasma levels of total 3-methoxy-4-hydroxyphenylglycol (MHPG) were measured in a group of 104 hospitalized depressed patients and a group of 104 age- and sex-matched normal controls. Plasma MHPG levels were found to be normally distributed in both groups and significantly lower in depressives than in controls. However, this difference could be related to an increase in plasma MHPG levels with age found in controls (r = 0.601, d.f. = 102, p < 0.01) but not in depressives (r = 0.013, d.f. = 102, NS). Men had significantly higher levels than women in both groups. There was no significant difference in plasma MHPG levels among any DSM-III-R diagnostic subgroups of depressives or between patients who were suppressors on the dexamethasone suppression test and those who were nonsuppressors. Significant correlations were found between AMDP Depression Rating Scale item and total scores and levels of plasma MHPG. Age, sex and clinical symptoms appeared to be main sources of variance in studying depressed patients and comparing them with normal controls.

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Origin and distribution of 3-methoxy-4-hydroxyphenylglycol in body fluids

Cited by 110 publications

References 79 publications

Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks

Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks

Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine

Plasma Levels of 3-Methoxy-4-Hydroxyphenylglycol in Depressed Patients Compared with Normal Controls

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