Origin and evolutionary characteristics of antigenic reassortant influenza A (H1N2) viruses isolated from man in China

Li, Xing Shan; Zhao, Chongbin; Gao, Hui; Zhang, Yu Qi; Ishida, Masatoshi; Kanegae, Yumi; Endo, Atsushi; Nerome, Reiko; Omoe, Katsuhiko; Nerome, Kuniaki

doi:10.1099/0022-1317-73-6-1329

Cited by 21 publications

(11 citation statements)

References 52 publications

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“…The emergence in nature of influenza A virus reassortants is well documented, especially between different virus subtypes in birds [9,18], as well as between viruses found in swine and avians [3,20,46]. Moreover, reassortants have been detected between H1N1 and H3N2 viruses infecting humans [2,16,25,47,48]. Thus, genetic reassortment between avian and human influenza strains does occur in the emergence of pandemic and interpandemic influenza A viruses.…”

Section: Discussionmentioning

confidence: 99%

Genetic reassortment in pandemic and interpandemic influenza viruses

et al. 1996

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The human influenza pandemics of 1957 and 1968 were caused by reassortant viruses that possessed internal gene segments from avian and human strains. Whether genetic reassortment of human and avian influenza viruses occurs during interpandemic periods and how often humans are infected with such reassortants is not known. To provide this information, we used dot-blot hybridization, partial nucleotide sequencing and subsequent phylogenetic analysis to examine the 6 internal genes of 122 viruses isolated in humans between 1933 and 1992 primarily from Asia, Europe, and the Americas. The internal genes of A/New Jersey/11/76 isolated from a human fatality at Fort Dix, New Jersey in 1976 were found to be of porcine origin. Although none of the geographically and temporally diverse collection of 122 viruses was an avian-human or other reassortant, cognizance was made of the fact that there were two isolates from children from amongst 546 influenza A isolates obtained from The Netherlands from 1989-1994 which were influenza A reassortants containing genes of avian origin, viruses which have infected European pigs since 1983-1985. Thus, genetic reassortment between avian and human influenza strains does occur in the emergence of pandemic and interpandemic influenza A viruses. However, in the interpandemic periods the reassortants have no survival advantage, and the circulating interpandemic influenza viruses in humans do not appear to accumulate avian influenza virus genes.

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Section: Discussionmentioning

confidence: 99%

Genetic reassortment in pandemic and interpandemic influenza viruses

et al. 1996

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“…Similarly, reassortant viruses of the H1N2 subtypes were isolated in China during the 1988/1989 influenza season but did not continue to circulate or spread widely (Guo et al, 1992;Li et al, 1992). It also seems unlikely that the reassortant influenza C virus, Nara/1/85, possessed an epidemiological advantage over the parental viruses; although more than 50 influenza C strains were isolated in Japan after 1985, none of the isolates had a genome composition identical to that of C/Nara/1/85 (unpublished data).…”

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confidence: 99%

Genetic reassortment of influenza C viruses in man

Gao

Hongō²,

Muraki³

et al. 1994

Journal of General Virology

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We reported previously that the antigenicity of the haemagglutinin-esterase (HE) glycoprotein of the human influenza C virus strain C/Nara/1/85 was indistinguishable from that of strain C/Nara/82. However, the ribonuclease Tl-oligonucleotide map of total virion RNA of C/Nara/1/85 differed remarkably from the map of C/Nara/82, resembling instead the map of C/Nara/ 2/85, which has an HE antigenicity dissimilar to C/Nara/82 and C/Nara/1/85. This observation raised the possibility that C/Nara/1/85 might have arisen by reassortment from two viruses closely related to C/Nara/ 82 and C/Nara/2/85, respectively. Here, we compared the total nucleotide sequence of the HE gene and partial sequences of the other genes of C/Nara/1/85 with those of C/Nara/82 and C/Nara/2/85. The results suggest that C/Nara/1/85 has inherited HE and NP genes from a C/Nara/82-related virus and the PB2, PB1, PA, M and NS genes from a C/Nara/2/85-related virus.

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“…The HAs of these strains were related to the human H1 viruses isolated since 1986 and the neuraminidases were most closely related to those of the recent human H3N2 viruses. They were derived from the cocirculating human strains [22,23] (table 1).…”

mentioning

confidence: 99%

Genetic Characterization of a Porcine H1N2 Influenza Virus Strain Isolated in Germany

Schrader¹,

Süß²

2003

Intervirology

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We examined selected influenza virus strains from various outbreaks of respiratory diseases among pigs in Germany. Besides H3N2 and H1N1 subtypes presently circulating in Europe, an H1N2 influenza virus was isolated in 2000. Sequence analysis of hemagglutinin, neuraminidase and matrix genes indicated that this virus is a reassortant of human H1N1 and human H3N2 strains with an internal gene, the M gene of avian origin. It is a result of a multiple reassortment event.

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Origin and evolutionary characteristics of antigenic reassortant influenza A (H1N2) viruses isolated from man in China

Cited by 21 publications

References 52 publications

Genetic reassortment in pandemic and interpandemic influenza viruses

Genetic reassortment in pandemic and interpandemic influenza viruses

Genetic reassortment of influenza C viruses in man

Genetic Characterization of a Porcine H1N2 Influenza Virus Strain Isolated in Germany

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