Origin and Molecular Characteristics of a Novel 2013 Avian Influenza A(H6N1) Virus Causing Human Infection in Taiwan

Yuan, Jian; Zhang, Lei; Kan, Xianzhao; Lan, Jing; Yang, Junli; Guo, Zhu Ming; Ren, Qiongqiong

doi:10.1093/cid/cit479

Cited by 118 publications

(97 citation statements)

References 8 publications

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“…Consistent with recently published data (Yuan et al, 2013), in the PB2, PA, and M trees, the closest strains of A/Taiwan/2/2013 and A/chicken/Taiwan/A2837/2013 belonged to the H5N2 subtype rather than H6N1 (Figs. 2 and 3), with the closest strains being A/chicken/Taiwan/0101/2012 (H5N2) for PB2 and PA, and A/chicken/Taiwan/A1997/2012 (H5N2) for M.…”

Section: Co-circulating H5n2 Infl Uenza Viruses Reassorted With H6n1 supporting

confidence: 91%

“…A recent publication proposes that A/Taiwan/2/2013 (H6N1) originated from a reassortment between H5N2 (PB2, PA, and M) and H6N1 subtypes based on phylogenetic analyses (Yuan et al, 2013). However, the formation of the novel H6N1 infl uenza viruses from H5N2 viruses was not fully supported by our phylogenetic and coalescent analyses.…”

Section: Protein Cell and Materials And Methodscontrasting

confidence: 73%

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Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan

Shi

et al. 2013

Protein Cell

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In June 2013, the fi rst human H6N1 infl uenza virus infection was confirmed in Taiwan. However, the origin and molecular characterization of this virus, A/Taiwan/2/2013 (H6N1), have not been well studied thus far. In the present report, we performed phylogenetic and coalescent analyses of this virus and compared its molecular profi le/characteristics with other closely related strains. Molecular characterization of H6N1 revealed that it is a typical avian infl uenza virus of low pathogenicity, which might not replicate and propagate well in the upper airway in mammals. Phylogenetic analysis revealed that the virus clusters with A/chicken/Taiwan/A2837/2013 (H6N1) in seven genes, except PB1. For the PB1 gene, A/Taiwan/2/2013 was clustered with a different H6N1 lineage from A/chicken/Taiwan/ A2837/2013. Although a previous study demonstrated that the PB2, PA, and M genes of A/Taiwan/2/2013 might be derived from the H5N2 viruses, coalescent analyses revealed that these H5N2 viruses were derived from more recent strains than that of the ancestor of A/Taiwan/2/2013. Therefore, we propose that A/Taiwan/2/2013 is a reassortant from different H6N1 lineages circulating in chickens in Taiwan. Furthermore, compared to avian isolates, a single P186L (H3 numbering) substitution in the hemagglutinin H6 of the human isolate might increase the mammalian receptor binding and, hence, this strain's pathogenicity in humans. Overall, human infection with this virus seems an accidental event and is unlikely to cause an infl uenza pandemic. However, its co-circulation and potential reassortment with other infl uenza subtypes are still worthy of attention.

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Section: Co-circulating H5n2 Infl Uenza Viruses Reassorted With H6n1 supporting

confidence: 91%

Section: Protein Cell and Materials And Methodscontrasting

confidence: 73%

Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan

Shi

et al. 2013

Protein Cell

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“…Four of these experienced ILI; throat swabs and paired serological samples were found to be negative for this influenza A(H6N1) virus. 29 Avian influenza A(H6N1) viruses commonly circulate in domestic bird populations in the region 30 and throughout the world. Although previous serological studies have documented antibodies to influenza A(H6) in humans 31,32,33 this is the first report of a symptomatic human infection with an avian influenza A(H6N1) virus.…”

Section: Human Infection With Influenza A(h6n1) Virusesmentioning

confidence: 99%

“…Quatre ont manifesté un syndrome grippal; des écouvillons pharyngés et des échantil-lons sérologiques appariés se sont révélés négatifs pour ce virus grippal A(H6N1). 29 Des virus de la grippe aviaire A(H6N1) circulent couramment dans les populations d'oiseaux domestiques de la région 30 et dans le monde entier. Bien que des études sérologiques anté-rieures aient attesté la présence d'anticorps contre la grippe A(H6) chez l'homme, 31,32,33 c'est le premier rapport d'une infection humaine symptomatique avec un virus de la grippe aviaire A(H6N1).…”

Section: Human Infections With Influenza A(h10n8) Virusesunclassified

Sensitivity and Specificity Estimation for the Clinical Diagnosis of Highly Pathogenic Avian Influenza in the Egyptian Participatory Disease Surveillance Program

Verdugo

Masry²,

Makonnen³

et al. 2016

Avian Diseases

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“…1,2 The indexed case has the respiratory illness. Presently, the medical scientist focuses concern on the new H6N1 influenza infection.…”

mentioning

confidence: 99%

Emerging H6N1 influenza infection: renal problem to be studied

Err

Wiwanitkit

2014

Renal Failure

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Origin and Molecular Characteristics of a Novel 2013 Avian Influenza A(H6N1) Virus Causing Human Infection in Taiwan

Cited by 118 publications

References 8 publications

Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan

Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan

Sensitivity and Specificity Estimation for the Clinical Diagnosis of Highly Pathogenic Avian Influenza in the Egyptian Participatory Disease Surveillance Program

Emerging H6N1 influenza infection: renal problem to be studied

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