Origin of a High-Latitude Population of Aedes aegypti in Washington, DC

Gloria‐Soria, Andrea; Lima, Andrew; Lovin, Diane D.; Cunningham, Joanne M.; Severson, David W.; Powell, Jeffrey R.

doi:10.4269/ajtmh.17-0676

Cited by 42 publications

(42 citation statements)

References 54 publications

(64 reference statements)

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“…We sampled 20 populations of Aedes aegypti originating from continental Africa and nearby Reunion Island (Figure , Table ) covering a large part of the Aaf distribution. We also used 10 previously studied populations (Gloria‐Soria et al., ; Kotsakiozi et al., ) of Aaa originating from the New World and Asia (Table ). Aedes mascarensis from the island of Mauritius was used as an outgroup; this species is very closely related to Ae.…”

Section: Methodsmentioning

confidence: 99%

Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa

Kotsakiozi

Evans

Gloria‐Soria

et al. 2018

Ecology and Evolution

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112

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Aedes aegypti, the major vector of dengue, yellow fever, chikungunya, and Zika viruses, remains of great medical and public health concern. There is little doubt that the ancestral home of the species is Africa. This mosquito invaded the New World 400‐500 years ago and later, Asia. However, little is known about the genetic structure and history of Ae. aegypti across Africa, as well as the possible origin(s) of the New World invasion. Here, we use ~17,000 genome‐wide single nucleotide polymorphisms (SNPs) to characterize a heretofore undocumented complex picture of this mosquito across its ancestral range in Africa. We find signatures of human‐assisted migrations, connectivity across long distances in sylvan populations, and of local admixture between domestic and sylvan populations. Finally, through a phylogenetic analysis combined with the genetic structure analyses, we suggest West Africa and especially Angola as the source of the New World's invasion, a scenario that fits well with the historic record of 16th‐century slave trade between Africa and Americas.

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Section: Methodsmentioning

confidence: 99%

Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa

Kotsakiozi

Evans

Gloria‐Soria

et al. 2018

Ecology and Evolution

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112

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“…Comparison of global population structure was achieved by comparing a subset of 2,630 of our SNP's from Panama that were shared with a previously acquired Ae. aegypti SNP dataset from 26 other countries worldwide (19)(20)(21)(22)(23). FastStructure analysis revealed that the number of model components and model maximum likelihood were maximised by assigning each individual to between K4-6 populations.…”

Section: Resultsmentioning

confidence: 99%

“…FastStructure analysis with a logistic prior was also applied to 2,630 SNP's shared with a worldwide SNP dataset representing Ae. aegypti from 26 different countries (19)(20)(21)(22)(23).…”

Section: Methodsmentioning

confidence: 99%

The impact of biological invasion and genomic local adaptation on the geographical distribution of Aedes aegypti in Panama

Bennett¹,

McMillan²,

Loaiza

2019

Preprint

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Local adaptation is an important consideration when predicting arthropod-borne disease risk because it can impact on individual vector fitness and vector population persistence. However, the extent that populations are adapted to local environmental conditions remains unknown. Here, we identified 128 candidate SNPs, clustered within 17 genes, which show a strong genetic signal of adaptation across Panama. Analysis of genome-wide SNPs showed that the local adaptation of Aedes aegypti mosquito populations occurs across relatively fine geographic scales. The composition and frequency of candidate adaptive loci differed between populations in wet tropical environments along the Caribbean coast and the dry tropical conditions typical of the Pacific coast of Panama. Temperature and vegetation were important predictors of adaptive genomic variation in Ae. aegypti with areas of local adaptation occurring within the Caribbean region of Bocas del Toro, the Pacific coastal areas of Herrera and Panama City and the eastern Azuero Peninsula. In addition, we found that the geographic distribution of Ae. aegypti across Panama is rapidly changing as a consequence of the recent invasion by its ecological competitor, Aedes albopictus. Although Ae. albopictus has displaced Ae. aegypti in some areas, species coexist across many areas, including regions where Ae. aegypti are locally adapted. Our results guide future experimental work by suggesting that adaptive variation within Ae. aegypti is affecting the outcome of inter-specific competition with Ae. albopictus and, as a consequence, may fundamentally alter future arborviral disease risk and efforts to control mosquito populations.

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“…Similar SNP datasets to that used in this study have proved useful for investigating the source of newly established Ae. aegypti populations (J. E. Brown et al, 2014;Gloria-Soria et al, 2018). The high level of genetic structuring at local and regional scales in this species suggests that genomewide SNP analyses are likely to be informative for determining the origin of incursive mosquitoes, provided reference mosquitoes are available in sufficient numbers from a range of potential source populations.…”

Section: Fig 1: Number Of Ae Aegypti Detections Per Year At Australimentioning

confidence: 99%

Tracking genetic invasions: genome-wide SNPs reveal the source of pyrethroid-resistantAedes aegypti(yellow fever mosquito) incursions at international ports

Schmidt

Rooyen²,

Chung

et al. 2018

Preprint

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Biological invasions are increasing globally in number and extent despite efforts to restrict their spread. Knowledge of incursion pathways is necessary to prevent new invasions and to design effective biosecurity protocols at source and recipient locations. This study uses genome-wide single-nucleotide polymorphisms (SNPs) to determine the origin of 115 incursive Aedes aegypti (yellow fever mosquito) detected at international ports in Australia and New Zealand. We also genotyped mosquitoes at three point mutations in the voltage-sensitive sodium channel (Vssc) gene: V1016G, F1534C, and S989P. These mutations confer knockdown resistance to synthetic pyrethroid insecticides, widely used for controlling invertebrate pests. We first delineated reference populations using Ae. aegypti sampled from 15 locations in Asia, South America, Australia and the Pacific Islands. Incursives were assigned to these populations using discriminant analysis of principal components (DAPC) and an assignment test with a support vector machine predictive model. Bali, Indonesia, was the most common origin of Ae. aegypti detected in Australia, while Ae. aegypti detected in New Zealand originated from Pacific Islands such as Fiji. Most incursives had the same allelic genotype across the three Vssc gene point mutations, which confers strong resistance to synthetic pyrethroids, the only insecticide class used in current, widely-implemented aircraft disinsection protocols endorsed by the World Health Organisation (WHO). Additionally, all internationally-assigned Ae. aegypti had Vssc point mutations linked to pyrethroid resistance that are not found in Australian populations. These findings demonstrate that protocols for preventing introductions of invertebrates must consider insecticide resistance, and highlights the usefulness of genomic datasets for managing global biosecurity objectives.

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Origin of a High-Latitude Population of Aedes aegypti in Washington, DC

Cited by 42 publications

References 54 publications

Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa

Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa

The impact of biological invasion and genomic local adaptation on the geographical distribution of Aedes aegypti in Panama

Tracking genetic invasions: genome-wide SNPs reveal the source of pyrethroid-resistantAedes aegypti(yellow fever mosquito) incursions at international ports

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