New geochronologic, geochemical, and isotopic data for Mesozoic to Cenozoic igneous rocks and detrital minerals from the Pamir Mountains help to distinguish major regional magmatic episodes and constrain the tectonic evolution of the Pamir orogenic system. After final accretion of the Central and South Pamir terranes during the Late Triassic to Early Jurassic, the Pamir was largely amagmatic until the emplacement of the intermediate (SiO 2 > 60 wt. %), calcalkaline, and isotopically evolved (-13 to-5 zircon εHf (t)) South Pamir batholith between 120-100 Ma, which is the most volumetrically significant magmatic complex in the Pamir and includes a high flux magmatic event at ~105 Ma. The South Pamir batholith is interpreted as the northern (inboard) equivalent of the Cretaceous Karakoram batholith and the along-strike equivalent of an Early Cretaceous magmatic belt in the northern Lhasa terrane in Tibet. The northern Lhasa terrane is characterized by a similar high-flux event at ~110 Ma. Migration of continental arc magmatism into the South Pamir terrane during the mid-Cretaceous is interpreted to reflect northward directed, low-angle to flat-slab subduction of the Neo-Tethyan oceanic lithosphere. Late Cretaceous magmatism (80-70 Ma) in the Pamir is scarce, but concentrated in the Central and northern South Pamir terranes where it is comparatively more mafic (SiO 2 < 60 wt. %), alkaline, and isotopically juvenile (-2 to +2 zircon εHf (t)) than the South Pamir batholith. Late Cretaceous magmatism in the Pamir is interpreted here to be the result of extension *Manuscript Click here to view linked References directly south of the Tanymas-Jinsha suture zone, an important lithospheric and rheological boundary that focused mantle lithosphere deformation after India-Asia collision. Miocene magmatism (20-10 Ma) in the Pamir includes:1) isotopically evolved migmatite and leucogranite related to crustal anataxis and decompression melting within extensional gneiss domes, and; 2) localized intra-continental magmatism in the Dunkeldik/Taxkorgan complex. Bangong suture zone (Fig. 1) (Yin and Harrison, 2000). The Qiangtang terrane is laterally equivalent to (from north to south) the Central Pamir terrane, the South Pamir terrane, and the Karakoram terrane, whereas there is no direct equivalent of the Lhasa terrane in the Pamir (Fig. 1 and 2) (Robinson et al., 2012). The Central Pamir terrane was accreted to the Triassic Karakul-Mazar arc-accretionary complex along the Tanymas suture (Fig. 2) (Burtman and Molnar, 1993) and the Qiangtang terrane was accreted to the Triassic Songpan-Ganzi turbidite complex along the Jinsha suture in Tibet during Late Triassic-Early Jurassic time (Yin and Harrison, 2000). The Karakul-Mazar complex in the Pamir consists of relatively undeformed Late Triassic intermediate intrusive rocks that were emplaced into a Triassic accretionary complex (Schwab et al., 2004; Robinson et al., 2012). The Karakul-Mazar magmatic rocks are believed to have originated above a north-dipping subduction zone (Schwab et al...