Origin of the pulmonary venous orifice in the mouse and its relation to the morphogenesis of the sinus venosus, extracardiac mesenchyme (spina vestibuli), and atrium

Tasaka, Hiroyasu; Krug, Edward L.; Markwald, Roger R.

doi:10.1002/(sici)1097-0185(199609)246:1<107::aid-ar12>3.0.co;2-t

Cited by 59 publications

(65 citation statements)

References 22 publications

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“…Its connection to the left atrium is explained by the formation of the primary interatrial septum, which is said to form along the right side of the MCPV. On the other hand, we can find several studies in which the initial position of the MCPV was already found within the left half of the venous heart pole (His, 1887;Born, 1889;Flint, 1906;Hochstetter, 1906;Fedorow, 1910;Robertson, 1914;Neill, 1956;Goor and Lillehei, 1975;Los, 1978;Tasaka et al, 1996). An interesting variant of the latter theme may exist in lizard, alligator, and chick embryos.…”

Section: Introductionmentioning

confidence: 92%

“…Much of the recent research activities on pulmonary vein development have focused on the question of whether the CPV is initially connected to a confluence chamber for the systemic venous tributaries, traditionally called the ''sinus venosus,'' or to the primitive atrium (DeRuiter et al, 1995;Tasaka et al, 1996;Blom et al, 2001;Webb et al, 1998Webb et al, , 2000Webb et al, , 2001Soufan et al, 2004;Anderson et al, 2006;Mä nner and Merkel, 2007). In this context, whether a venous confluence chamber really exists as a discrete morphological segment in the heart of higher vertebrate embryos before the appearance of the MCPV has been questioned (Webb et al, 1998Soufan et al, 2004;Anderson et al, 2006).…”

Section: Position Of the Mcpv With Respect To The Systemic Venous Trimentioning

confidence: 99%

“…This situation may be interpreted as evidence that the caudalmost portion of the dorsal atrial wall belongs to the sinus venosus. Divergent interpretations of the morphological situation may also explain different descriptions of pulmonary vein development in higher vertebrates, where some authors have also seen the initial position of the MCPV within the dorsal wall of the sinus venosus (His, 1887;Flint, 1906;Hochstetter, 1906;Fedorow, 1910;Brown, 1913;Buell, 1922;Dor et al, 1987;Kutsche and Van Mierop, 1988;DeRuiter et al, 1995;Tasaka et al, 1996;Blom et al, 2001). …”

Section: Position Of the Mcpv With Respect To The Systemic Venous Trimentioning

confidence: 99%

“…Its later confinement to the left atrial cavity is explained mainly by the formation of the primary interatrial septum (Born, 1889;Neill, 1956;Van Praagh and Corsini, 1969;Goor and Lillehei, 1975;Los, 1978;Webb et al, 1998Webb et al, , 2000Webb et al, , 2001Soufan et al, 2004;Anderson et al, 2006;Männer and Merkel, 2007;Bertens et al, 2010;Sizarov et al, 2010). On the other hand, there are data, which seem to suggest that the initial position of the MCPV is within the dorsal wall of the sinus venosus (Goette, 1875;His, 1887;Flint, 1906;Hochstetter, 1906;Fedorow, 1910;Brown, 1913;Buell, 1922;Dor et al, 1987;Kutsche and Van Mierop, 1988;DeRuiter et al, 1995;Tasaka et al, 1996;Blom et al, 2001). The connection of the CPV to the developing left atrium is explained by a positional shift of its mouth combined with the formation of the primary interatrial septum.…”

Section: Introductionmentioning

confidence: 99%

“…While much of the recent research activities on pulmonary vein development have focused on the question of whether the CPV is initially connected to the sinus venosus or to the primitive atrium (DeRuiter et al, 1995;Tasaka et al, 1996;Blom et al, 2001;Webb et al, 1998;Soufan et al, 2004;Anderson et al, 2006), only little attention has been paid to the questions of whether and how the topogenesis of the MCPV is mechanistically linked to the specification of the L-R body axis. This is surprising since it is a well-known fact that human congenital cardiac malformations with bilaterally symmetric arrangement of the atrial appendages, so-called left and right atrial isomerism, are frequently associated with abnormal connections of the systemic and pulmonary venous tributaries (Uemura et al, 1996;Smith et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Development of the venous pole of the heart in the frog Xenopus laevis: A morphological study with special focus on the development of the venoatrial connections

Jahr

Männer

2011

Developmental Dynamics

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The heart of lung-breathing vertebrates normally shows an asymmetric arrangement of its venoatrial connections along the left-right (L-R) body axis. The systemic venous tributaries empty into the right atrium while the pulmonary venous tributaries empty into the left atrium. The ways by which this asymmetry evolves from the originally symmetrically arranged embryonic venous heart pole are poorly defined. Here we document the development of the venous heart pole in Xenopus laevis (stages 40-46). We show that, prior to the appearance of the mouth of the common pulmonary vein (MCPV), the systemic venous tributaries empty into a bilaterally symmetric chamber (sinus venosus) that is demarcated from the developing atriums by a circular ridge of tissue (sinu-atrial ridge). A solitary MCPV appears during stage 41. From the time point of its first appearance onwards, the MCPV lies cranial to the sinu-atrial ridge and to the left of the developing interatrial septum and body midline. L-R lineage analysis shows that the interatrial septum and MCPV both derive from the left body half. The CPV, therefore, opens from the beginning into the future left atrium. The definitive venoatrial connections are established by the formation of a septal complex that divides the lumen of the venous heart pole into systemic and pulmonary venous flow pathways. This complex arises from the anlage of the interatrial septum and the left half of the sinu-atrial ridge. Developmental Dynamics 240:1518-1527,

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Section: Introductionmentioning

confidence: 92%

Section: Position Of the Mcpv With Respect To The Systemic Venous Trimentioning

confidence: 99%

Section: Position Of the Mcpv With Respect To The Systemic Venous Trimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of the venous pole of the heart in the frog Xenopus laevis: A morphological study with special focus on the development of the venoatrial connections

Jahr

Männer

2011

Developmental Dynamics

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Expression of theMf1 gene in developing mouse hearts: Implication in the development of human congenital heart defects

et al. 1999

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The transcription factor FKHL7 gene has recently been associated with the anterior segment dysgenesis disorder of the eye known as Axenfeld-Rieger anomaly (ARA). A growing body of evidence indicates that mutations in FKHL7 cause not only defects in the anterior segment of the eye but defects in the heart valves and septa as well. In order to evaluate its contribution to normal heart septation and valve formation, expression of the mouse homologue Mf1 in embryonic hearts was analyzed by in situ hybridization. A weak but significant level of Mf1 expression could be detected in the endocardium of mouse embryos as early as day 8.5 post-conception (p.c.). Mf1 expression was undetectable in the hearts of day 9.5 p.c. embryos, but by day 10.5-11 p.c., Mf1 transcripts could be found again in the endocardium of both the atrium and ventricle and a relatively strong signal was observed in the dorsal portion of the septum primum, in what appeared to be the spinal vestibule. At day 13 p.c. when aortic and pulmonary trunks are separated, relatively more Mf1 transcripts were detected in the leaflets of aortic, pulmonary, and venous valves, the ventral portion of the septum primum, as well as in the single layer of cells on the edges of the atrioventricular cushion tissues. Surprisingly, there was no signal detected in the developing interventricular septum. At day 15 p.c., overall Mf1 signals were greatly decreased. However, significant levels of expression could still be observed in the atrial septum, the tricuspid valve, the mitral valve, and in the venous valve but not in the interventricular septum. The temporal and spatial expression patterns of the Mf1 gene in developing mouse hearts suggest that Mf1 may play a critical role in the formation of valves and septa with the exception of the interventricular septum. This is further supported by our studies showing that mutations in the FKHL7 gene were associated with defects in the anterior segment of the eye as well as atrial septal defects or mitral valve defects.

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Development of the murine pulmonary vein and its relationship to the embryonic venous sinus

Webb¹,

Brown²,

Wessels³

et al. 1998

Anat. Rec.

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Background: Arguments concerning the development of the pulmonary vein, and its relationship to the embryonic venous sinus (sinus venosus) have continued for well over a century. Recently, attention has again been focused on the origin of the pulmonary vein. It has been suggested that, whereas the pulmonary vein originates from the left atrium in humans, in all other vertebrates it originates from the venous sinus, with subsequent transfer to the left atrium. The nature of this transfer has not, however, been elucidated, although there is speculation that the pulmonary vein is ''pinched off'' from the left side of the embryonic venous sinus.Methods: We studied closely staged hearts of normal mouse embryos from a C57BL/6 x CBA cross days 10 and 11 of gestation (plug day ‫؍‬ day 1). Two series of embryos were collected and fixed in 2% glutaraldehyde, 1% formaldehyde, buffered with 0.05 M sodium cacodylate pH 7.4 (adjusted to 330 mOsm with NaCl). One series was wax embedded, serially sectioned, and stained with Masson's trichrome. The second series was subject to microdissection and scanning electron microscopy.Results: The atrial component of the heart tube is attached to the body of the embryo by reflections of the atrial myocardial wall. The attachment can be considered, from the outset, as the heart stalk, with the myocardialmesodermal connections forming a horseshoe of tissue that projects ventrally into the lumen of the atrium, surrounding a single evagination in the midline of the embryo. This heart stalk is cranial to the connections of the tributaries of the embryonic venous sinus and ventral to the foregut. When traced through its developmental stages, the evagination in the centre of the stalk, which we describe as the pulmonary pit, is seen to become the portal of entry for the developing pulmonary vein.Conclusions: The heart stalk, representing the area used by the pulmonary vein to gain access to the heart, and analogous to the dorsal mesocardium, is, from the outset, discrete from the area occupied by the orifices of the horns of the embryonic venous sinus. The pulmonary vein does not, in the mouse, develop from the tissues that form the walls of the tributaries of the systemic venous sinus. Comparisons with other studies suggest that early events in the development of the pulmonary vein are likely to be the same in all mammals, including humans. Anat.

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Origin of the pulmonary venous orifice in the mouse and its relation to the morphogenesis of the sinus venosus, extracardiac mesenchyme (spina vestibuli), and atrium

Cited by 59 publications

References 22 publications

Development of the venous pole of the heart in the frog Xenopus laevis: A morphological study with special focus on the development of the venoatrial connections

Development of the venous pole of the heart in the frog Xenopus laevis: A morphological study with special focus on the development of the venoatrial connections

Expression of theMf1 gene in developing mouse hearts: Implication in the development of human congenital heart defects

Development of the murine pulmonary vein and its relationship to the embryonic venous sinus

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