Original article. Development of chitosan/nanosized apatite composites for bone cements

Abstract

Background: Calcium phosphate cements (CPC) is a promising materials for bone defect repair. Nanosized apatite or calcium orthophosphate has a better bioactivity than coarser crystals. Chitosan is produced commercially from chitin that is the structural element in the exoskeleton of crustaceans such as crabs and shrimp. The mixing of nanosized apatite and chitosan may provide the consistency cement, improving mechanical properties of the set bone cement. Objective: Develop nanosized apatite powder with chitosan for bone composite cement. Materials and method: Nanosized apatite was synthesized by chemical method at low temperature and used as the single-component for bone cement. The nanosized apatite powder was characterized using X-ray diffraction method, Fourier transform infrared spectroscopy, and transmission electron microscopy. CPCs were developed based on chitosan/nanosized apatite and calcium sulfate hemihydrate. The compressive strength of the set cement was measured after one to four weeks. The phase composition and the morphology of the set cements were investigated. Results: Calcium sulfate hemihydrate was effective in increasing the compressive strength after setting in a simulated body fluid for seven days. The compressive strength of chitosan/nanosized apatite composite was about 18 MPa after soaking. Conclusion:The workability and setting time of this composite were suitable to handling for bone cement. These composite cements had a significant clinical advantage for substitution of the regenerated bone.

Design Strategies and Biomimetic Approaches for Calcium Phosphate Scaffolds in Bone Tissue Regeneration

“…Incorporation of sodium alginate caused a general decrease in setting behavior with different power/liquid ratios and increase in compressive and tensile strength of the hardened biomaterial [ 199 ]. The employment of other types of biopolymers, such as hyaluronic acid [ 200 , 201 ] and chitosan [ 202 ] revealed promising effects on cement injectability, making CPCs a viable example of bone filler for tissue engineering.…”