ORIGINAL ARTICLE: Follicular Fluid Levels of Interleukin‐10 and Interferon‐gamma do not Predict Outcome of Assisted Reproductive Technologies

Čerkienė, Živilė; Eidukaitė, Audronė; Usonienė, Audronė

doi:10.1111/j.1600-0897.2007.00552.x

Cited by 12 publications

(5 citation statements)

References 24 publications

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“…Many other cytokines (including GM‐CSF, HGF, IFN‐α, IFN‐γ, IL‐2, IL‐4, IL‐7, IL‐10, IL‐12, IL‐18, MCP‐1, MIP‐1β, and platelet‐derived growth factor (PDGF)) have been identified in follicular fluid (Orvieto et al, ; Bili et al, ; Artini et al, ; Kawano et al, ; Hammadeh et al, ; Dahm‐Kahler et al, ; Vujisic et al, ; Ostanin et al, ; Cerkiene et al, ; Ledee et al, ; Kilic et al, ; Boomsma et al, ; Pelzer et al, ; Yang et al, ; Lamaita et al, ; Sarapik et al, ). One recent study showed that IL‐8, IL‐18, and MIP‐1β levels positively correlated with pregnancy outcome in IVF cycles, while total IL‐12 levels reflected oocyte fertilisation and subsequent embryo development (Sarapik et al, ).…”

Section: Clinical Relevance Of Cytokine Network In Folliculogenesismentioning

confidence: 99%

Cytokines in ovarian folliculogenesis, oocyte maturation and luteinisation

Field

Dasgupta

Cummings

et al. 2013

Molecular Reproduction Devel

166

110

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SUMMARYCytokines are key regulators of ovarian physiology, particularly in relation to folliculogenesis and ovulation, where they contribute to creating an environment supporting follicle selection and growth. Their manifold functions include regulating cellular proliferation/differentiation, follicular survival/atresia, and oocyte maturation. Several cytokines, such as TGF-b-superfamily members, are involved at all stages of folliculogenesis while the production of others is stage-dependent. This review draws upon evidence from both human and animal models to highlight the species-specific roles at each milestone of follicular development. Given these pivotal roles and their ease of detection in follicular fluid, cytokines have been considered as attractive biomarkers of oocyte maturational status and of successful assisted reproductive outcome. Despite this, our understanding of cytokines and their interactions remains incomplete, and is still frequently limited to overly simplistic descriptions of their interrelationships. Given our increased appreciation of cytokine activity in complex and highly regulated networks, we put forward the case for using Bayesian modelling approaches to describe their hierarchical relationships in order to predict causal physiological interactions in vivo.Mol. Reprod. Dev. 81: 284À314,

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Section: Clinical Relevance Of Cytokine Network In Folliculogenesismentioning

confidence: 99%

Cytokines in ovarian folliculogenesis, oocyte maturation and luteinisation

Field

Dasgupta

Cummings

et al. 2013

Molecular Reproduction Devel

166

110

View full text Add to dashboard Cite

show abstract

“…In some studies, IL-2 and IL-10 were found to correlate with specific hormonal milieus within the follicle, but not with IVF outcome [ 65 - 67 ]. Ledee [ 68 ] recently detected significantly higher levels of IL-2 and interferon (IFN-gamma) in FFs whose oocytes generated early cleaving embryos.…”

Section: Introductionmentioning

confidence: 99%

Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics

Revelli

Piane

Casano

et al. 2009

Reprod Biol Endocrinol

529

397

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The assessment of oocyte quality in human in vitro fertilization (IVF) is getting increasing attention from embryologists. Oocyte selection and the identification of the best oocytes, in fact, would help to limit embryo overproduction and to improve the results of oocyte cryostorage programs. Follicular fluid (FF) is easily available during oocyte pick-up and theorically represents an optimal source on non-invasive biochemical predictors of oocyte quality. Unfortunately, however, the studies aiming to find a good molecular predictor of oocyte quality in FF were not able to identify substances that could be used as reliable markers of oocyte competence to fertilization, embryo development and pregnancy. In the last years, a well definite trend toward passing from the research of single molecular markers to more complex techniques that study all metabolites of FF has been observed. The metabolomic approach is a powerful tool to study biochemical predictors of oocyte quality in FF, but its application in this area is still at the beginning. This review provides an overview of the current knowledge about the biochemical predictors of oocyte quality in FF, describing both the results coming from studies on single biochemical markers and those deriving from the most recent studies of metabolomics.

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“…Higher FF IL-1b levels were associated with normal fertilization [60] leading to cytoplasmic maturation and normal fertilization, but do not play a role in embryo development. In some studies, IL-2, IL-10, interferon and granulocyte colony-stimulating factor (GCSF) were found to correlate with early cleaving embryos, whereas IL-12 levels were higher in the FF of follicles corresponding to highly fragmented embryos [61,62]. High level of soluble human leukocyte antigen G (sHLA-G) produced by granulosa and cumulus cells in FF with its immunosuppressive effect could predict the fertilization failure of the corresponding oocyte, but was not related with the formation of good-quality embryo [63,64].…”

mentioning

confidence: 97%

From global proteome profiling to single targeted molecules of follicular fluid and oocyte: contribution to embryo development and IVF outcome

Benkhalifa

Madkour

Louanjli³

et al. 2015

Expert Review of Proteomics

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The development of in vitro fertilization (IVF) techniques for infertility management has led to the investigation of the proteome of follicular fluid and oocyte. In addition, different markers contributing to oocyte maturation and embryo development potential have been reported in the literature. Different techniques were utilized to analyze whole proteome or single protein markers in follicular fluid and oocytes, particularly in animal models. Data from several studies have generated large amounts of information, however, an ideal profile to predict the best oocytes and embryos suitable for implantation are still to be uncovered. The identification of such profiles and markers from follicular fluid, oocytes and endometrium should help scientists and clinicians develop better strategies to improving clinical outcome of IVF cycles.

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ORIGINAL ARTICLE: Follicular Fluid Levels of Interleukin‐10 and Interferon‐gamma do not Predict Outcome of Assisted Reproductive Technologies

Abstract: Our study showed that IFN-gamma and IL-10 are not suitable markers in predicting outcome of assisted reproductive technologies.

Cited by 12 publications

References 24 publications

Cytokines in ovarian folliculogenesis, oocyte maturation and luteinisation

Cytokines in ovarian folliculogenesis, oocyte maturation and luteinisation

Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics

From global proteome profiling to single targeted molecules of follicular fluid and oocyte: contribution to embryo development and IVF outcome

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