ORIGINAL ARTICLE: Genistein Reverses Diminished T‐Cell Signal Transduction, Induced by Post‐Menopausal Estrogen Levels

Abstract

Genistein restores CD3zeta, NFkappaB and JAK3 proteins and mRNAs at post-meonopausal estrogen levels, in vitro, with no significant effect at pre-menopausal estrogen levels.

Anti-inflammatory effects of green soybean extract irradiated with visible light

“…However, genistein did not suppress IL-2 expression in Jurkat cells23, and in the present study, the levels of isoflavones were not significantly altered by the visible light irradiation. LIEGS suppressed IL-2 expression by blocking JNK signaling.…”

The role of environmental estrogens and autoimmunity

“…Genistein also blocked the progression of internalized high-affinity receptor for IgG to lysosomes. Moreover, it has been shown to reverse in vitro the loss of T-cell signaling components at post-menopausal estrogen levels, with no significant effect at pre-menopausal estrogen levels [92]. In broiler pulmonary arterial endothelial cells genistein stimulated a rapid phosphorylation of eNOS activating the eNOS/NO axis; the activation of eNOS was not mediated through estrogen receptors or tyrosine kinase inhibition, but via a phosphatidylinositol 3-kinase (PI3K)/Aktdependent signaling pathway, as the eNOS activity and related NO release were largely abolished by pharmacological inhibitors of PI3K or Akt [93].…”