Original article Sertraline and curcumin prevent stress-induced morphological changes of dendrites and neurons in the medial prefrontal cortex of rats

Noorafshan, Ali; Abdollahifar, Mohammad‐Amin; Karbalay‐Doust, Saied; Asadi-Golshan, Reza; Rashidian-Rashidabadi, Ali

doi:10.5114/fn.2015.49976

Cited by 22 publications

(6 citation statements)

References 41 publications

(65 reference statements)

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“…It was the result of their constant changing in response to neuronal activity (e.g., chronic stress; Segal et al, 2000). Moreover, the present study in parallel with other reports demonstrated that curcumin had protective effects on the number of changes of neurons of the prefrontal cortex and hippocampus reduced by stress (Noorafshan et al, 2014, 2015). Various studies have explained different protective mechanisms of the treatment for curcumin in various neurological disorders.…”

Section: Methodssupporting

confidence: 91%

Curcumin alleviates restraint stress-induced learning and memory deficit and activity via modulation of biochemical, morphology changes, and apoptosis in the prefrontal cortex and hippocampus.

Pourheydar¹,

Abar²,

Farjah³

et al. 2022

Behavioral Neuroscience

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Restraint stress indicated induction of morphology, biochemistry, and behavioral impairments. Several investigations have reported that curcumin has a protective effect against stress disturbance. The present study is designed to investigate the effects of curcumin on learning and memory, activity, biochemical, morphology changes, and apoptosis in the hippocampus and prefrontal cortex of restraint stress rats. For chronic restraint stress, the rats were kept in the restrainers for 2.5 h per day for 21 consecutive days. The animals received the gavage of curcumin every other day for 21 days. After stress, the animals were subjected to behavioral tests. In restraint stress rats, locomotor activity and step-through latency were decreased using open field and shuttle box, respectively. Then, the rats were sacrificed to assess their serum and brains. A reduction was seen in the serum malonedialdehyde levels and number of neurons in the hippocampus and prefrontal cortex. The significantly decreased serum total antioxidant capacity levels and increased apoptotic cells were observed in the hippocampus and prefrontal cortex. Finally, curcumin inhibited and reversed the changes of stress induced in the prefrontal cortex and hippocampus of the rats. These findings provided evidence for the protective effect of curcumin therapy on biochemical, morphology, and behavioral changes induced by restraint stress.

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Section: Methodssupporting

confidence: 91%

Curcumin alleviates restraint stress-induced learning and memory deficit and activity via modulation of biochemical, morphology changes, and apoptosis in the prefrontal cortex and hippocampus.

Pourheydar¹,

Abar²,

Farjah³

et al. 2022

Behavioral Neuroscience

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“…Sun et al (2013[25]) disclosed that CUR could also recover learning and memory in senescence-accelerated mice. Similarly, our previous studies revealed that CUR could play protective roles in rat prefrontal cortical neurons in different pathological conditions (Noorafshan et al, 2015[20]). SD could diminish the spatial memories and affect the mPFC structure.…”

Section: Discussionsupporting

confidence: 57%

Using curcumin to prevent structural and behavioral changes of medial prefrontal cortex induced by sleep deprivation in rats

Noorafshan

Karimi

Karbalay‐Doust

et al. 2017

EXCLI Journal; 16:Doc510; ISSN 1611-2156

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“…To estimate and calculate the average of striatal dendritic length per neuron, two essential quantities were required for evaluation: the first one was the number of neuronal cell body via an optical dissector method, and the second one was the crossings between oriented cycloid and dendrite axes. As a final point, average striatal dendritic length per neuron was calculated, using the unbiased stereological formula (Noorafshan, Abdollahifar, Karbalay‐Doust, Asadi‐Golshan, & Rashidian‐Rashidabadi, )…”

Section: Methodsmentioning

confidence: 99%

Functional dopaminergic neurons derived from human chorionic mesenchymal stem cells ameliorate striatal atrophy and improve behavioral deficits in Parkinsonian rat model

Ebrahimi

Boroujeni

Aliaghaei

et al. 2019

The Anatomical Record

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Human chorionic mesenchymal stem cells (HCMSCs) have been recognized as a desirable choice for cell therapy in neurological disorders such as Parkinson's disease (PD). Due to invaluable features of HCMSCs including their immunomodulatory and immunosuppressive properties, easily accessible and less differentiated compared to other types of MSCs, HCMSCs provide a great hope for regenerative medicine. Thus, the purpose of this study was to determine the in vitro and in vivo efficacy of HCMSCs‐derived dopaminergic (DA) neuron‐like cells with regard to PD. Initially, HCMSCs were isolated and underwent a 2‐week DA differentiation, followed by in vitro assessments, using quantitative real‐time polymerase chain reaction, immunocytochemistry, patch clamp recording, and high‐performance liquid chromatography. In addition, the effects of implanted HCMSCs‐derived DA neuron‐like cells on the motor coordination along with stereological alterations in the striatum of rat models of PD were investigated. Our results showed that under neuronal induction, HCMSCs revealed neuron‐like morphology, and expressed neuronal and DA‐specific genes, together with DA release. Furthermore, transplantation of HCMSCs‐derived DA neurons into the striatum of rat models of PD, augmented performance. Besides, it prevented reduction of striatal volume, dendritic length, and the total number of neurons, coupled with a diminished level of cleaved caspase‐3. Altogether, these findings suggest that HCMSCs could be considered as an attractive strategy for cell‐based therapies in PD.

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Original article Sertraline and curcumin prevent stress-induced morphological changes of dendrites and neurons in the medial prefrontal cortex of rats

Abstract: A b s t r a c t Stress induces structural and behavioral impairments. The changes in dendrites and neurons are accompanied by impairments in the tasks mediated by the medial prefrontal cortex (mPFC

Cited by 22 publications

References 41 publications

Curcumin alleviates restraint stress-induced learning and memory deficit and activity via modulation of biochemical, morphology changes, and apoptosis in the prefrontal cortex and hippocampus.

Curcumin alleviates restraint stress-induced learning and memory deficit and activity via modulation of biochemical, morphology changes, and apoptosis in the prefrontal cortex and hippocampus.

Using curcumin to prevent structural and behavioral changes of medial prefrontal cortex induced by sleep deprivation in rats

Functional dopaminergic neurons derived from human chorionic mesenchymal stem cells ameliorate striatal atrophy and improve behavioral deficits in Parkinsonian rat model

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