ORIGINAL ARTICLE: Temporal and Spatial Expression of Tumor‐Associated Antigen RCAS1 in Pregnant Mouse Uterus

Tskitishvili, Ekaterine; Nakamura, Hitomi; Kinugasa-Taniguchi, Yukiko; Kanagawa, Takeshi; Kimura, Tadashi; Tomimatsu, Takuji; Shimoya, Koichiro

doi:10.1111/j.1600-0897.2009.00772.x

Cited by 6 publications

(9 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3][4][5][6][7][8] As tumor growth occurs only within the stroma that supports this growth, the tumor microenvironment is also involved in this process. This microenvironment is created mainly by the suppressive activity of the cancer cells and is a natural consequence of the fact that the front of the tumor is more involved in this process of immune suppression than the central part.…”

Section: Introductionmentioning

confidence: 99%

The Immunohistochemical Analysis of Antigens such as RCAS1 and B7H4 in the Cervical Cancer Nest and within the Fibroblasts and Macrophages Infiltrating the Cancer Microenvironment

Gałązka

Opławski

Windorbska³

et al. 2012

American J Rep Immunol

View full text Add to dashboard Cite

Introduction The presence of the aggressive phenotype of the tumor seems to be indicated by the local infiltration of cancer cells and by the development of metastases in the lymph nodes. This phenotype is related to the intensity of the suppressive profile of the tumor microenvironment. The aim of our study has been to gather information about the expression of both RCAS1 and B7H4 proteins in the macrophages and fibroblasts present within both the microenvironment of cervical cancer tumors and the cancer cells present on the front of the cancer nest. Methods We analyzed the immunoreactivity levels of such antigens as B7H4 and RCAS1 in the macrophages and fibroblasts of the cancer microenvironment and within the cancer nest in the tissue samples derived from patients on whom both a radical hysterectomy and a lymphadenectomy had been performed following a diagnosis of uterine cervical carcinoma. These patients were then divided into two subgroups according to the extent of the local and distant advancement of the cancer – that is, according to the FIGO stage and the presence or absence of lymph node metastases. Results RCAS1 immunoreactivity levels on the front of the cancer nest statistically significantly increase according to the FIGO stage or the extent of the local spread of the disease while B7H4 immunoreactivity levels on the tumor front increase in relation to the extent of the distant spread of the disease or the presence of lymph nodes metastases. Conclusion The intensity of the suppressive profile of the cervical cancer microenvironment indicated by the presence of both RCAS1 and B7H4 on the front of the tumor and in the macrophages and fibroblasts infiltrating the cancer stroma seems to correlate with the extent of both the local and distant advancement of the disease.

show abstract

Section: Introductionmentioning

confidence: 99%

The Immunohistochemical Analysis of Antigens such as RCAS1 and B7H4 in the Cervical Cancer Nest and within the Fibroblasts and Macrophages Infiltrating the Cancer Microenvironment

Gałązka

Opławski

Windorbska³

et al. 2012

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

“…17 There have been several studies investigating the RCAS1 expression and immune tolerance during pregnancy, 18,19 and its connection with fetal maturity, 20 stillbirth, 21,22 the process of placental detachment. 25 The aim of this study was to assess the role of RCAS1 protein expression in maternal blood during the course of uncomplicated human pregnancies and to define its predictive value for pregnancy outcome. 25 The aim of this study was to assess the role of RCAS1 protein expression in maternal blood during the course of uncomplicated human pregnancies and to define its predictive value for pregnancy outcome.…”

Section: Discussionmentioning

confidence: 99%

“…2 The RCAS1 protein mRNA levels in maternal blood plasma at 11-13, 20-22, 32-34, and 37-38 weeks of gestation during the course of uncomplicated pregnancy and after delivery. RCAS is expressed in the placenta during pregnancy in humans 5,18 as well as in mice with the higher expression levels on day 7.5 p.c, which corresponds to the period of placenta-tion, 25 suggesting the possible role of RCAS1 in immune privilege during pregnancy. The ratio (expressed in arbitrary units) in maternal blood plasma was significantly up-regulated at 11-13 weeks of gestation than that at 37-38 weeks of gestation.…”

Section: Discussionmentioning

confidence: 99%

“…5 Our recent studies revealed strong connection between RCAS1 antigen and gestational diabetes mellitus, 23 pre-eclampsia, 24 and its role in the maintenance of the normal pregnancy in mice has been studied. 25 The aim of this study was to assess the role of RCAS1 protein expression in maternal blood during the course of uncomplicated human pregnancies and to define its predictive value for pregnancy outcome.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Blood Serum and Plasma Human Tumor‐Associated Antigen RCAS1 During the Course of Uncomplicated Pregnancies: A Prospective Study

Tskitishvili

Sharentuya

Tsubouchi

et al. 2010

American J Rep Immunol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Trophoblast cells participate in these processes through the secretion of interleukins, such as IL-10 [3] as well as through the expression by the cell membranes of particular molecules, such as those membrane proteins that are involved in the evasion of immune surveillance [4,5,6]. Two of these proteins, RCAS1 [7,8,9] and HLA-G [10,11,12], have been widely described recently: HLA-G is known as a marker enabling the diagnosis of different types of tumors derived from trophoblasts [2,12] while the role of RCAS1 in molar lesions has not currently been examined. RCAS1 is involved in the suppression of maternal cytotoxic cells [13,14].…”

Section: Introductionmentioning

confidence: 99%

Analysis of RCAS1 Immunoreactivity within Hydatidiform Mole Cells and Decidual Cells according to the Applied Therapeutic Strategy: Surgery or Surgery Followed by Chemotherapy

Wicherek¹,

Basta²,

Wertel³

et al. 2012

Gynecol Obstet Invest

View full text Add to dashboard Cite

Introduction: Trophoblast cells cooperate with both maternal immune cells and decidual cells to help develop the suppressive microenvironment of the endometrium. The maternal immune response against hydatidiform mole depends on this suppressive endometrial profile. Since RCAS1 is one of the molecular factors participating in the development of the suppressive profile of the endometrium we decided to examine the immunoreactivity of the RCAS1 within both the trophoblast and decidual cells during the development of hydatidiform mole. Methods: We analyzed the immunoreactivity of RCAS1 on both trophoblast and decidual cells derived from patients who underwent curettage because of hydatidiform mole. These patients were then divided into two subgroups according to whether or not they required chemotherapy after the surgical procedure. Result: We observed significantly lower immunoreactivity levels of both RCAS1 within the complete molar lesions of the patients on whom surgery alone was performed when compared to the levels found in those for whom surgery was followed by chemotherapy. Conclusion: RCAS1 staining may provide information regarding the intensity of the immunosuppressive microenvironment of both the molar lesion and the endometrium. This information can prove significant in determining the clinical course of hydatidiform mole.

show abstract

ORIGINAL ARTICLE: Temporal and Spatial Expression of Tumor‐Associated Antigen RCAS1 in Pregnant Mouse Uterus

Abstract: The results of this study suggest the importance of day 7.5 p.c. for RCAS1 protein expression in connection with placentation as a possible target for future in vivo studies.

Cited by 6 publications

References 29 publications

The Immunohistochemical Analysis of Antigens such as RCAS1 and B7H4 in the Cervical Cancer Nest and within the Fibroblasts and Macrophages Infiltrating the Cancer Microenvironment

The Immunohistochemical Analysis of Antigens such as RCAS1 and B7H4 in the Cervical Cancer Nest and within the Fibroblasts and Macrophages Infiltrating the Cancer Microenvironment

Maternal Blood Serum and Plasma Human Tumor‐Associated Antigen RCAS1 During the Course of Uncomplicated Pregnancies: A Prospective Study

Analysis of RCAS1 Immunoreactivity within Hydatidiform Mole Cells and Decidual Cells according to the Applied Therapeutic Strategy: Surgery or Surgery Followed by Chemotherapy

Contact Info

Product

Resources

About