Origins of Laboratory Mice Deduced from Restriction Patterns of Mitochondrial DNA

Yonekawa, Hiromichi; Moriwaki, Kazuo; Gotoh, Osamu; Miyashita, Nobumoto; Migita, Shunsuke; Bonhomme, François; Hjorth, J.; Petras, Michael L.; Tagashira, Yusaku

doi:10.1111/j.1432-0436.1982.tb01255.x

Cited by 133 publications

(63 citation statements)

References 26 publications

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“…Different molecular markers suggest that the main contributors are M. musculus musculus (Bishop et al 1985), M. musculus domesticus (Yonekawa et al 1982;Sakai et al 2005), and, to a lesser extent, M. musculus castaneus (Sakai et al 2005). One other subspecies that is usually considered to have contributed is M. musculus molossinus (Sakai et al 2005), although this itself is supposed to be a hybrid between M. m. musculus and M. m. castaneus (Lundrigan et al 2002;Wade et al 2002).…”

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confidence: 99%

mtDNA phylogeny and evolution of laboratory mouse strains

Goios¹,

Pereira²,

Bogue³

et al. 2007

Genome Res.

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Inbred mouse strains have been maintained for more than 100 years, and they are thought to be a mixture of four different mouse subspecies. Although genealogies have been established, female inbred mouse phylogenies remain unexplored. By a phylogenetic analysis of newly generated complete mitochondrial DNA sequence data in 16 strains, we show here that all common inbred strains descend from the same Mus musculus domesticus female wild ancestor, and suggest that they present a different mitochondrial evolutionary process than their wild relatives with a faster accumulation of replacement substitutions. Our data complement forthcoming results on resequencing of a group of priority strains, and they follow recent efforts of the Mouse Phenome Project to collect and make publicly available information on various strains.

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confidence: 99%

mtDNA phylogeny and evolution of laboratory mouse strains

Goios¹,

Pereira²,

Bogue³

et al. 2007

Genome Res.

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“…The rare Hbbs gene, e. g. is present in Nagasawa's SLN stocks is also observed in some dd stock mice. Recently Yonekawa et al also [65] showed that a closed colony ddY has a mixture of dom.estlcus and molossinus mitochondrial DNAs suggesting that the original dd stock was contaminated with another mice of different origin.…”

Section: (Received 8 October 1985/accepted 31 January 1986)mentioning

confidence: 99%

Genetic Marker Patterns and Endogenous Mammary Tumor Virus Genes in Inbred Mouse Strains of Japan

Imai

Morimoto

Tsubura

et al. 1986

Experimental Animals

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In order to establish the genetic relatedness of the inbred mouse strains kept in Nara , genetic marker patterns were determined in conjunction with a study on endogenous mammary tumor viral genes in these strains .Isoenzyme patterns combined with patterns of other genetic markers, show that the unrelatedness between various inbred strains of the dd stock is as high or even higher as between strains of known different origin and geneology. Based on endogenous viral gene patterns the dd stock derived mice can be subdivided into three group, (1) DDD , DDN, DDO, (2) KF and (3) DD/ Tbr. The DD/Tbr and its foster-nursed substrain (DD/Tbrf) have the lowest number of endogenous viral genes, i. e. two, while the other strains carry 4-6 such genes . The SLN and SHN strains, derived from a Swiss stock, have a similar pattern of viral genes different that of all other strains studied, also strains of Swiss origin from other sources, such as the NFS and the GR .

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“…The majority of disease models have been reported in laboratory strains of mice and rats. Since laboratory strains are derived from a relatively narrow ancestry [29,30], exploration of much broader resources should be a promising source of novel disease models. Japanese rodents are advantageous for study because of -ReviewReview Series: Wild Mice in Laboratory Animal Science their geographic isolation from the ancestors of laboratory mice.…”

Section: Introductionmentioning

confidence: 99%

Japanese Wild Mice: A Rich Resource for New Disease Models

Matsushima

2012

Exp. Anim.

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Abstract:Breeding of fancy mice has been a tradition in Japan. Recent progress in animal science has shed a new light on Japanese wild-derived mice as tools for discovery of new disease models because these mice, Mus musculus molossinus, are genetically far remote from the majority of available laboratory mice. After decades of effort, five inbred strains of mice have been established from pairs of wild mice trapped in Tohoku, northeastern Japan, namely KOR1/Stm, KOR5/Stm, KOR7/Stm, AIZ/Stm, and MAE/Stm. They carried numerous mutations, leading to a variety of diseases. During the inbreeding of KOR1, the first spontaneous mutation was found in the Apoe (apolipoprotein E) gene, and the mutant was later designated as spontaneous hyperlipidemic (SHL). Thereafter, a number of other mutations were discovered among wild-derived inbred strains, including atopic dermatitis, microphthalmia, dominant white spots, sebaceous gland abnormalities, and audible song-like vocalization. Furthermore, to examine the possible effects of the genetic background for these mutant genes, sets of congenic strains were generated, in which the mutant gene was introduced into at least 3 different strains of laboratory mice, including BALB/c and C57BL/6. These congenic strains have now been established as novel disease models. These wildderived inbred strains serve as a treasure trove for novel disease models. Most of them have been deposited in the Riken BioResource Center (BRC), and some are also available from commercial breeders.

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Origins of Laboratory Mice Deduced from Restriction Patterns of Mitochondrial DNA

Cited by 133 publications

References 26 publications

mtDNA phylogeny and evolution of laboratory mouse strains

mtDNA phylogeny and evolution of laboratory mouse strains

Genetic Marker Patterns and Endogenous Mammary Tumor Virus Genes in Inbred Mouse Strains of Japan

Japanese Wild Mice: A Rich Resource for New Disease Models

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